Personale

Recapiti

Orario di ricevimento

Italiano

Curriculum

Interessi

Pubblicazioni

Insegnamenti

Carla GHELARDINI

Ruolo attuale:: Professore Ordinario
SSD:: BIO/14 - Farmacologia
Afferenza organizzativa:: Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)

Recapiti

	0552758196
	carla.ghelardini(AT)unifi.it

Carla GHELARDINI

Curriculum

STUDI

Laurea in Chimica e Tecnologia Farmaceutiche (1985) ed in Farmacia (1995)

Dottorato di Ricerca in Farmacologia e Tossicologia (1992)

ATTIVITA’ PROFESSIONALE

1996 Ricercatore universitario per il settore BIO-14 -

2001 Professore associato SSD BIO-14 -

2007-2009 Presidente del Corso di Laurea in Informazione Scientifica sul Farmaco

2010 -2018 Presidente del Corso di Laurea in Farmacia

2012 Professore ordinario per SSD 05/G1

2013-2017 Membro del Consiglio di Amministrazione dlla Fondazione Toscana Life Science

2017 ad oggi Coordinatrice del Dottorato di Ricerca in Area del Farmaco e Trattamenti Innovativi

2017 ad oggi Segretaria del Consiglio Direttivo della Società Italiana di Farmacologia e Membro del Comitato SIF-Farmindustria

2019 ad oggi Presidente Ce.S.A.L e RAPPRESENTANTE DEL DIPARTIMENTO NEUROFARBA PRESSO LA SCUOLA DI SCIENZE DELLA SALUTE UMANA (UNIFI)

E' coautrice di 481 pubblicazioni su riviste internazionali e di 18 brevetti

PREMI RICEVUTI

1987 Premio UPJOHN - Excellence in Pharmacology - SIF

1992 Premio dell'Ass. Ricerche Neurologiche

1993 Premio dell’ European College of Neuropsychopharmacology

1994 Premio "CINP Rafaelsen"

1996 Premio "Leonardo Donatelli" - Soc.Italiana di Farmacologia

Menzione ufficiale premio "Linus Pauling" Soc. Int. di Med.Molecolare

1997 Premio "Young Investigator" Soc. Europea di Neurochimica

1998 Premio "Pharmacological Research" Soc. Italiana di Farmacologia

1999 Premio da parte della Soc.Italiana di Farmacognosia

2005 Premio da parte della Soc. Italiana di Fitoterapia

ALTRI INCARICHI

Vice-direttrice del Dipartimento NEUROFARBA

Presidente CESAL

Delegata del rettore per lòa Fondazioe Toscana Life Science

Responsabile di Convenzioni di Ricerca con le seguenti Aziende Farmaceutiche: Nikem Research, Brane Discovery, Neurotune, Sigma-Tau, Aboca, MDM, Rottapharm. Menarini, La.Fa.Re, Apharm.

Responsabile di numerosi assegni di ricerca, borse di studio e Co.Co.Co

Membro della Commissione giudicatrice per la valutazione comparativa per un posti di ricercatore e Professore associato in numerose sedi italiane

Incarico di ideazione e progettazione, selezione ed orientamento dei partecipanti, e coordinamento didattico del modulo professionalizante “Tecnico Esperto nel Settore Dermofarmacologico

Tutor di laureati per lo svolgimento di un tirocinio post-laurea presso l’azienda Eli Lilly di Firenze

Incarico di collaborazioner alla realizzazione della prima edizione italiana della monografia ESCOP “Le basi scientifiche dei prodotti fitoterapici” (Edizioni Planta Medica)

Membro della Commissione Budget della Scuola di Scienze della Salute Umana

Assistenza sperimentale presso i laboratori Guidotti di Pisa e I.B.I.S. di Firenze ed ha collaborato con l'Istiuto Farmaceutico L.P.B. (Milano) e con le Società Manetti e Roberts (Firenze), FIDIA (Padova), Molteni (Firenze), Solvay-Pharma (Torino), Sigma-Tau (Roma), Nikem Research (Milano), ABOCA (Arezzo), Brane Discovery (Varese), Neurotune (Zurigo), Rottapharm (Milano), MDM (Milano) e Apharm (Novara)

Membro dell’Editorial Baord di Neurppharmacology

ATTIVITA’ DI REFERAGGIO

Nature Rev. Neurol., Journal of Pharmacology and Experimental Therapeutics , Pain, Journal of Neurochemistry, European Journal Pharmacology, J. Medicinal Chemistry Life Sciences, Psychopharmacology, International Journal of Experimental and Clinic Pharmacology, Journal of Neuroscience Methods; Journal of Neuroscience Research, Behaviour Brain Research; Progress in Neuro-psychopharmacology & Biological Psychiatry, European Journal of Neuropsychopharmacology. Neuroscience Letters, Acta Pharmaceutica, Biochemical Pharmacology, Journal of Heterocyclic Chemistry, Archiv der Pharmazie, Pharmacology Biochemistry and Behaviour, NeuroSignals, The Journal of Headache and Pain, Journal of Psychopharmacology, Expert Opinion On Investigational Drugs, Acta Neuropathologica.

APPARTENENZA A SOCIETA’ SCIENTIFICHE

American Society for Neuroscience, International Brain Research Organization, European College of Neuropsychopharmacology, Italiana di Farmacologia, Società Italiana di Farmacognosia, Società Italiana di Neuroscienze, Ass. Italiana per lo Studio del dolore.

Carla GHELARDINI

Pubblicazioni

Legenda

Contributo su rivista |

Articolo su libro |

Libro |

Contributo in atti di convegno (proceeding) |

Brevetto |

Curatela | Altro

Altro |

Tesi di Dottorato

Angeli A.; Micheli L.; Carta F.; Ferraroni M.; Pirali T.; Fernandez Carvajal A.; Ferrer Montiel A.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T. (2023). First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 1616-1633, ISSN:0022-2623 DOI

Vanti, Giulia; Micheli, Laura; Berrino, Emanuela; Mannelli, Lorenzo Di Cesare; Bogani, Irene; Carta, Fabrizio; Bergonzi, Maria Camilla; Supuran, Claudiu T; Ghelardini, Carla; Bilia, Anna Rita (2023). Escinosome thermosensitive gel optimizes efficacy of CAI-CORM in a rat model of rheumatoid arthritis. JOURNAL OF CONTROLLED RELEASE, vol. 358, pp. 171-189, ISSN:0168-3659 DOI Accesso ONLINE all'editore

Berrino, Emanuela; Micheli, Laura; Carradori, Simone; di Cesare Mannelli, Lorenzo; Guglielmi, Paolo; De Luca, Alessandro; Carta, Fabrizio; Ghelardini, Carla; Secci, Daniela; Supuran, Claudiu T (2023). Novel Insights on CAI-CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 66, pp. 0-0, ISSN:0022-2623 DOI

Ferrara V.; Toti A.; Lucarini E.; Parisio C.; Micheli L.; Ciampi C.; Margiotta F.; Crocetti L.; Vergelli C.; Giovannoni M.P.; Di Cesare Mannelli L.; Ghelardini C. (2023). Protective and Pain-Killer Effects of AMC3, a Novel N-Formyl Peptide Receptors (FPRs) Modulator, in Experimental Models of Rheumatoid Arthritis. ANTIOXIDANTS, vol. 12, pp. 1207-1226, ISSN:2076-3921 DOI

Arias, Hugo R; Tae, Han-Shen; Micheli, Laura; Yousuf, Arsalan; Manetti, Dina; Romanelli, Maria Novella; Ghelardini, Carla; Adams, David J; Di Cesare Mannelli, Lorenzo (2023). The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor. ANESTHESIA AND ANALGESIA, vol. 137, pp. 691-701, ISSN:0003-2999 DOI

Balayssac D.; Busserolles J.; Broto C.; Dalbos C.; Prival L.; Lamoine S.; Richard D.; Quintana M.; Herbet A.; Hilairet S.; Hu Y.; Loryan I.; Glaab W.E.; Micheli L.; Ghelardini C.; Di Cesare Mannelli L.; Perrault O.; Slaoui M. (2023). Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project. BIOMEDICINE & PHARMACOTHERAPY, vol. 167, pp. 0-0, ISSN:1950-6007 DOI

Micheli L.; Rajamoni J.; Di Cesare Mannelli L.; Rajagopalan P.; Ghelardini C.; Rajagopalan R. (2023). DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy. BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 95, pp. 0-0, ISSN:1464-3405 DOI

Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Mosti, Carla Ghelardini, Anna Rita Bilia, Maria Camilla Bergonzi (2023). Antinociceptive Action of Thymoquinone-Loaded Liposomes in an In Vivo Model of Tendinopathy. PHARMACEUTICS, pp. 0-0, ISSN:1999-4923

Lucarini E.; Micheli L.; Toti A.; Ciampi C.; Margiotta F.; Di Cesare Mannelli L.; Ghelardini C. (2023). Anti-Hyperalgesic Efficacy of Acetyl L-Carnitine (ALCAR) Against Visceral Pain Induced by Colitis: Involvement of Glia in the Enteric and Central Nervous System. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 24, pp. 0-0, ISSN:1422-0067 DOI

Lucarini, Elena; Micheli, Laura; Rajagopalan, Raghavan; Ciampi, Clara; Branca, Jacopo Junio Valerio; Pacini, Alessandra; Leandri, Massimo; Rajagopalan, Parthasarathi; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2023). Broad-spectrum neuroprotection exerted by DDD-028 in a mouse model of chemotherapy-induced neuropathy. PAIN, vol. 00, pp. 0-0, ISSN:0304-3959 DOI Accesso ONLINE all'editore

Avagliano, Carmen; De Caro, Carmen; Cuozzo, Mariarosaria; Liguori, Fabrizio Maria; La Rana, Giovanna; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Paciello, Orlando; Russo, Roberto (2022). Phaseolus vulgaris extract ameliorates high-fat diet-induced colonic barrier dysfunction and inflammation in mice by regulating peroxisome proliferator-activated receptor expression and butyrate levels. FRONTIERS IN PHARMACOLOGY, vol. 13, pp. 0-0, ISSN:1663-9812 DOI

Micheli, Laura; Lucarini, Elena; Nobili, Stefania; Bartolucci, Gianluca; Pallecchi, Marco; Toti, Alessandra; Ferrara, Valentina; Ciampi, Clara; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2022). Ultramicronized N-palmitoylethanolamine contributes to morphine efficacy against neuropathic pain: implication of mast cells and glia. CURRENT NEUROPHARMACOLOGY, vol. 21, pp. 0-0, ISSN:1570-159X DOI

Micheli, Laura; Toti, Alessandra; Lucarini, Elena; Ferrara, Valentina; Ciampi, Clara; Olivero, Guendalina; Pittaluga, Anna; Mattoli, Luisa; Pelucchini, Caroline; Burico, Michela; Lucci, Jacopo; Carrino, Donatello; Pacini, Alessandra; Pallanti, Stefano; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2022). Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and ex vivo analysis. FRONTIERS IN NUTRITION, vol. 9, pp. 0-0, ISSN:2296-861X DOI

Branca, Jacopo Junio Valerio; Carrino, Donatello; Paternostro, Ferdinando; Morucci, Gabriele; Fiorillo, Claudia; Nicoletti, Claudio; Gulisano, Massimo; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Becatti, Matteo; Pacini, Alessandra (2022). The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model. CELLS, vol. 11, pp. 0-0, ISSN:2073-4409 DOI

Micheli, Laura; Maramai, Samuele; Toti, Alessandra; Ferrara, Valentina; Ciampi, Clara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2022). Inhibition of Monoacylglycerol Lipase by NSD1819 as an Effective Strategy for the Endocannabinoid System Modulation against Neuroinflammation-Related Disorders. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 0-0, ISSN:1422-0067 DOI

Micheli L.; Lucarini E.; Toti A.; Ferrara V.; Ciampi C.; Parisio C.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C. (2022). Effects of Ultramicronized N-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention. PHARMACEUTICS, vol. 14, pp. 403-403, ISSN:1999-4923 DOI

Lucarini E.; Micheli L.; Pagnotta E.; Matteo R.; Parisio C.; Toti A.; Ferrara V.; Ciampi C.; Martelli A.; Testai L.; Calderone V.; Savino M.; Russo M.; Pecchioni N.; Ghelardini C.; Di Cesare Mannelli L. (2022). Beneficial Effects of Eruca sativa Defatted Seed Meal on Visceral Pain and Intestinal Damage Resulting from Colitis in Rats. FOODS, vol. 11, pp. 580-580, ISSN:2304-8158 DOI

Vallarino G.; Salis A.; Lucarini E.; Turrini F.; Olivero G.; Roggeri A.; Damonte G.; Boggia R.; Di Cesare Mannelli L.; Ghelardini C.; Pittaluga A. (2022). Healthy Properties of a New Formulation of Pomegranate‐Peel Extract in Mice Suffering from Experimental Autoimmune Encephalomyelitis. MOLECULES, vol. 27, pp. 914-914, ISSN:1420-3049 DOI

D'Antongiovanni, Vanessa; Pellegrini, Carolina; Benvenuti, Laura; Fornai, Matteo; Di Salvo, Clelia; Natale, Gianfranco; Ryskalin, Larisa; Bertani, Lorenzo; Lucarini, Elena; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Nemeth, Zoltan H; Haskó, György; Antonioli, Luca (2022). Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis. INFLAMMATION, vol. 45, pp. 1829-1847, ISSN:0360-3997 DOI

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Cervetto, Chiara; Toti, Alessandra; Lucarini, Elena; Parisio, Carmen; Marcoli, Manuela; Ghelardini, Carla (2022). Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain. NEUROBIOLOGY OF DISEASE, vol. 168, pp. 105716-105716, ISSN:0969-9961 DOI

Lucarini E.; Micheli L.; Di Cesare Mannelli L.; Ghelardini C. (2022). Naturally occurring glucosinolates and isothiocyanates as a weapon against chronic pain: potentials and limits. PHYTOCHEMISTRY REVIEWS, vol. 21, pp. 647-665, ISSN:1568-7767 DOI

Lucarini E.; Micheli L.; Pagnotta E.; Toti A.; Ferrara V.; Ciampi C.; Margiotta F.; Martelli A.; Testai L.; Calderone V.; Matteo R.; Suriano S.; Troccoli A.; Pecchioni N.; Manera C.; Di Cesare Mannelli L.; Ghelardini C. (2022). The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief. NUTRIENTS, vol. 14, pp. 3137-3137, ISSN:2072-6643 DOI

Crocetti, Letizia; Guerrini, Gabriella; Giovannoni, Maria Paola; Melani, Fabrizio; Lamanna, Silvia; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2022). New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 4827-4855, ISSN:1422-0067 DOI

Coppi E.; Cherchi F.; Venturini M.; Lucarini E.; Corradetti R.; Mannelli Di Cesare Lorenzo.; Ghelardini C.; Pedata F.; Pugliese A.M. (2022). Therapeutic Potential of Highly Selective A3 Adenosine Receptor Ligands in the Central and Peripheral Nervous System. MOLECULES, vol. 27, pp. 1890-1904, ISSN:1420-3049 DOI

Bonardi, Alessandro; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T (2022). Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 13143-13157, ISSN:1520-4804 DOI

Micheli, Laura; Mitidieri, Emma; Turnaturi, Carlotta; Vanacore, Domenico; Ciampi, Clara; Lucarini, Elena; Cirino, Giuseppe; Ghelardini, Carla; Sorrentino, Raffaella; Di Cesare Mannelli, Lorenzo; d'Emmanuele di Villa Bianca, Roberta (2022). Beneficial Effect of H2S-Releasing Molecules in an In Vitro Model of Sarcopenia: Relevance of Glucoraphanin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 5955-5955, ISSN:1422-0067 DOI

Gado F.; Ferrisi R.; Polini B.; Mohamed K.A.; Ricardi C.; Lucarini E.; Carpi S.; Domenichini F.; Stevenson L.A.; Rapposelli S.; Saccomanni G.; Nieri P.; Ortore G.; Pertwee R.G.; Ghelardini C.; Di Cesare Mannelli L.; Chiellini G.; Laprairie R.B.; Manera C. (2022). Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: From Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 9918-9938, ISSN:1520-4804 DOI

Akande, Titilayo; Khatib, Mohamad; Ola Salawu, Sule; Afolabi Akindahunsi, Akintunde; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Balli, Diletta; Cecchi, Lorenzo; Mulinacci, Nadia (2022). 1H NMR and HPLC-DAD-MS for the characterization of ellagitannins and triterpenoids of less investigated Anogeissus leiocarpus DC (Combretaceae) stem bark. FOOD CHEMISTRY, vol. 375, pp. 0-0, ISSN:0308-8146 DOI Accesso ONLINE all'editore

Morgese M.G.; Bove M.; Di Cesare Mannelli L.; Schiavone S.; Colia A.L.; Dimonte S.; Mhillaj E.; Sikora V.; Tucci P.; Ghelardini C.; Trabace L. (2022). Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity. FRONTIERS IN PHARMACOLOGY, vol. 12, pp. 799561-799561, ISSN:1663-9812 DOI

Micheli L.; Parisio C.; Lucarini E.; Carrino D.; Ciampi C.; Toti A.; Ferrara V.; Pacini A.; Ghelardini C.; Di Cesare Mannelli L. (2022). Restorative and pain-relieving effects of fibroin in preclinical models of tendinopathy. BIOMÉDECINE & PHARMACOTHÉRAPIE, vol. 148, pp. 112693-112693, ISSN:0753-3322 DOI

Akgul O.; Lucarini E.; Mannelli L.D.C.; Ghelardini C.; D'Ambrosio K.; Buonanno M.; Monti S.M.; De Simone G.; Angeli A.; Supuran C.T.; Carta F. (2022). Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 227, pp. 0-0, ISSN:0223-5234 DOI

Vanti, Giulia; Capizzi, Michela; Mannelli, Lorenzo Di Cesare; Lucarini, Elena; Bergonzi, Maria Camilla; Ghelardini, Carla; Bilia, Anna Rita (2022). Escinosomes: Safe and Successful Nanovesicles to Deliver Andrographolide by a Subcutaneous Route in a Mice Model of Oxaliplatin-Induced Neuropathy. PHARMACEUTICS, vol. 14, pp. 493-493, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Bua, Silvia; Combs, Jacob; Lomelino, Carrie; Andring, Jacob; Osman, Sameh Mohamed; Toti, Alessandra; Di Cesare Mannelli, Lorenzo; Gratteri, Paola; Ghelardini, Carla; McKenna, Robert; Nocentini, Alessio; Supuran, Claudiu T (2022). The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 37, pp. 930-939-939, ISSN:1475-6366 DOI

Micheli L.; Testai L.; Angeli A.; Carrino D.; Pacini A.; Margiotta F.; Flori L.; Supuran C.T.; Calderone V.; Ghelardini C.; Mannelli L.D.C. (2022). Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, pp. 6229-6229, ISSN:1661-6596 DOI

Lucarini E, Di Pilato V, Parisio C, Micheli L, Toti A, Pacini A, Bartolucci G, Baldi S, Niccolai E, Amedei A, Rossolini GM, Nicoletti C, Cryan JF, O'Mahony SM, Ghelardini C, Di Cesare Mannelli L. (2021). Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence. PAIN, pp. 1-17, ISSN:1872-6623

Bulli I.; Dettori I.; Coppi E.; Cherchi F.; Venturini M.; Mannelli L.D.C.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 5029-5038, ISSN:1661-6596 DOI

Lucrezia Caselli, Marco Mendozza, Beatrice Muzzi, Alessandra Toti, Costanza Montis, Tommaso Mello, Lorenzo Di Cesare Mannelli, Carla Ghelardini,Claudio Sangregorio, Debora Berti (2021). Lipid Cubic Mesophases Combined with Superparamagnetic Iron Oxide Nanoparticles: A Hybrid Multifunctional Platform with Tunable Magnetic Properties for Nanomedical Applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 9268-9268, ISSN:1661-6596 DOI

Giuseppe Giannaccare 1, Carla Ghelardini, Alessandra Mancini 1, Vincenzo Scorcia 1, Lorenzo Di Cesare Mannelli (2021). New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease. JOURNAL OF CLINICAL MEDICINE, pp. 108-108, ISSN:2077-0383

Di Cesare Mannelli L.; Esposito F.P.; Sangiovanni E.; Pagano E.; Mannucci C.; Polini B.; Ghelardini C.; Dell'agli M.; Izzo A.A.; Calapai G.; de Pascale D.; Nieri P. (2021). Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources. PHARMACEUTICALS, vol. 14, pp. 1329-1329, ISSN:1424-8247 DOI

Alma Martelli 1 2 3, Eugenia Piragine 1, Era Gorica 1, Valentina Citi 1, Lara Testai , Eleonora Pagnotta 4, Luca Lazzeri 4, Nicola Pecchioni 5, Valerio Ciccone 6, Rosangela Montanaro 7, Lorenzo Di Cesare Mannelli , Carla Ghelardini , Vincenzo Brancaleone 7, Lucia Morbidelli 6, Vincenzo Calderone (2021). The H 2 S-Donor Erucin Exhibits Protective Effects against Vascular Inflammation in Human Endothelial and Smooth Muscle Cells. ANTIOXIDANTS, pp. 961-961, ISSN:2076-3921

Mura P.; Maestrelli F.; Cirri M.; Nerli G.; Di Cesare Mannelli L.; Ghelardini C.; Mennini N. (2021). Improvement of butamben anesthetic efficacy by the development of deformable liposomes bearing the drug as cyclodextrin complex. PHARMACEUTICS, vol. 13, pp. 0-0, ISSN:1999-4923 DOI

Micheli L.; Vasarri M.; Barletta E.; Lucarini E.; Ghelardini C.; Degl'Innocenti D.; Di Cesare Mannelli L. (2021). Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice. MARINE DRUGS, vol. 19, pp. 48-62, ISSN:1660-3397 DOI Accesso ONLINE all'editore

Angeli A.; Pinteala M.; Maier S.S.; Toti A.; Di Cesare Mannelli L.; Ghelardini C.; Selleri S.; Carta F.; Supuran C.T. (2021). Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 45, pp. 0-0, ISSN:0960-894X DOI

Branca, Jacopo Junio Valerio; Carrino, Donatello; Gulisano, Massimo; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2021). Oxaliplatin-Induced Neuropathy: Genetic and Epigenetic Profile to Better Understand How to Ameliorate This Side Effect. FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 8, pp. 0-0, ISSN:2296-889X DOI Accesso ONLINE all'editore

Micheli L.; Durante M.; Lucarini E.; Sgambellone S.; Lucarini L.; Di Cesare Mannelli L.; Ghelardini C.; Masini E. (2021). The histamine h4 receptor participates in the anti-neuropathic effect of the adenosine a3 receptor agonist ib-meca: Role of cd4+ t cells. BIOMOLECULES, vol. 11, pp. 1447-1447, ISSN:2218-273X DOI

Lucarini E.; Seguella L.; Vincenzi M.; Parisio C.; Micheli L.; Toti A.; Corpetti C.; Del Re A.; Squillace S.; Maftei D.; Lattanzi R.; Ghelardini C.; Di Cesare Mannelli L.; Esposito G. (2021). Role of enteric glia as bridging element between gut inflammation and visceral pain consolidation during acute colitis in rats. BIOMEDICINES, vol. 9, pp. 1671-1671, ISSN:2227-9059 DOI

Congiu M.; Micheli L.; Santoni M.; Sagheddu C.; Muntoni A.L.; Makriyannis A.; Malamas M.S.; Ghelardini C.; Di Cesare Mannelli L.; Pistis M. (2021). N-Acylethanolamine Acid Amidase Inhibition Potentiates Morphine Analgesia and Delays the Development of Tolerance. NEUROTHERAPEUTICS, pp. 0-0, ISSN:1933-7213 DOI

Micheli L., Parisio C., Lucarini E., Vona A., Toti A., Pacini A., Mello T., Boccella S., Ricciardi F., Maione S., Graziani G., Lacal P.M., Failli P., Ghelardini C., Di Cesare Mannelli L. (2021). VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, pp. 1-19, ISSN:1756-9966 DOI

Micheli L., Rajagopalan R., Lucarini E., Toti A., Parisio C., Carrino D., Pacini A., Ghelardini C., Rajagopalan P., Di Cesare Mannelli L. (2021). Pain Relieving and Neuroprotective Effects of Non-opioid Compound, DDD-028, in the Rat Model of Paclitaxel-Induced Neuropathy. NEUROTHERAPEUTICS, pp. 1-13, ISSN:1933-7213 DOI

Tanini D.; Carradori S.; Capperucci A.; Lupori L.; Zara S.; Ferraroni M.; Ghelardini C.; Mannelli L.D.C.; Micheli L.; Lucarini E.; Carta F.; Angeli A.; Supuran C.T. (2021). Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 225, pp. 0-0, ISSN:0223-5234 DOI

Crocetti, Letizia; Guerrini, Gabriella; Puglioli, Sara; Giovannoni, Maria Paola; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Wang, Junjie; Dahl, Gerhard (2021). Design and synthesis of the first indole-based blockers of Panx-1 channel. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 223, pp. 113650-113660, ISSN:0223-5234 DOI

Dettori I.; Fusco I.; Bulli I.; Gaviano L.; Coppi E.; Cherchi F.; Venturini M.; Di Cesare Mannelli L.; Ghelardini C.; Nocentini A.; Supuran C.T.; Pugliese A.M.; Pedata F. (2021). Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 36, pp. 964-976, ISSN:1475-6366 DOI

Coppi E.; Cherchi F.; Lucarini E.; Ghelardini C.; Pedata F.; Jacobson K.A.; Mannelli L.D.C.; Pugliese A.M.; Salvemini D. (2021). Uncovering the mechanisms of adenosine receptor-mediated pain control: Focus on the a3 receptor subtype. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, pp. 7952-7964, ISSN:1661-6596 DOI

Crocetti, Letizia; Vergelli, Claudia; Guerrini, Gabriella; Giovannoni, Maria Paola; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Schepetkin, Igor A.; Quinn, Mark T. (2021). Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis. MOLECULES, vol. 26, pp. 6583-6583, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Vanti, Giulia; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Cinci, Lorenzo; Grifoni, Lucia; Bergonzi, Maria Camilla; Ghelardini, Carla; Bilia, Anna Rita (2021). The Anti-Arthritic Efficacy of Khellin Loaded in Ascorbyl Decanoate Nanovesicles after an Intra-Articular Administration. PHARMACEUTICS, vol. 13, pp. 1275-1275, ISSN:1999-4923 DOI

Varano, Flavia; Catarzi, Daniela; Vigiani, Erica; Dal Ben, Diego; Buccioni, Michela; Marucci, Gabriella; Di Cesare Mannelli, Lorenzo; Lucarini, Elena; Ghelardini, Carla; Volpini, Rosaria; Colotta, Vittoria (2021). Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression. PHARMACEUTICALS, vol. 14, pp. 0-0, ISSN:1424-8247 DOI

Lucarini E., Nocentini A., Bonardi A., Chiaramonte N., Parisio C., Micheli L., Toti A., Ferrara V., Carrino D., Pacini A., Romanelli M.N., Supuran C.T., Ghelardini C., Di Cesare Mannelli L. (2021). Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats. CELLS, vol. 10, pp. 2540-2555, ISSN:2073-4409 DOI

Nobili S.; Lucarini E.; Murzilli S.; Vanelli A.; Di Cesare Mannelli L.; Ghelardini C. (2021). Efficacy evaluation of plant products in the treatment of erectile dysfunction related to diabetes. NUTRIENTS, vol. 13, pp. 4520-4520, ISSN:2072-6643 DOI

Biagiotti G.; Angeli A.; Giacomini A.; Toniolo G.; Landini L.; Salerno G.; Di Cesare Mannelli L.; Ghelardini C.; Mello T.; Mussi S.; Ravelli C.; Marelli M.; Cicchi S.; Menna E.; Ronca R.; Supuran C.T.; Richichi B. (2021). Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells. ACS APPLIED NANO MATERIALS, vol. 4, pp. 14153-14160, ISSN:2574-0970 DOI Accesso ONLINE all'editore

Mariaconcetta Durante 1 2, Silvia Squillace 1 3 4, Filomena Lauro 1 3 5, Luigino Antonio Giancotti 1 3, Elisabetta Coppi 2, Federica Cherchi 2, Lorenzo Di Cesare Mannelli, Carla Ghelardini , Grant Kolar 3 6, Carrie Wahlman 1, Adeleye Opejin 7, Cuiying Xiao 8, Marc L Reitman 8, Dilip K Tosh 8, Daniel Hawiger 7, Kenneth A Jacobson 8, Daniela Salvemini 1 3 (2021). Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10. THE JOURNAL OF CLINICAL INVESTIGATION, pp. e139299-e139299, ISSN:1558-8238

Di Cesare Mannelli L.; Micheli L.; Lucarini E.; Parisio C.; Toti A.; Tenci B.; Zanardelli M.; Branca J.J.V.; Pacini A.; Ghelardini C. (2020). Effects of the combination of β-hydroxy-β-methyl butyrate and R(+) lipoic acid in a cellular model of sarcopenia. MOLECULES, vol. 25, pp. 1-18, ISSN:1420-3049 DOI

Nocentini A.; Alterio V.; Bua S.; Micheli L.; Esposito D.; Buonanno M.; Bartolucci G.; Osman S.M.; Alothman Z.A.; Cirilli R.; Pierini M.; Monti S.M.; Di Cesare Mannelli L.; Gratteri P.; Ghelardini C.; De Simone G.; Supuran C.T. (2020). Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 5185-5200, ISSN:0022-2623 DOI

Lucarini E., Trallori E., Tomassoni D., Amenta F., Ghelardini C., Pacini A.*, Di Cesare Mannelli L. (2020). Toxicological profile of the pain-relieving antioxidant compound thioctic acid in its racemic and enantiomeric forms.. ANTIOXIDANTS, vol. 9, pp. 749-764, ISSN:2076-3921 DOI

Parisio C.; Lucarini E.; Micheli L.; Toti A.; Bellumori M.; Cecchi L.; Calosi L.; Bani D.; Di Cesare Mannelli L.; Mulinacci N.; Ghelardini C. (2020). Extra virgin olive oil and related by-products (: Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats. FOOD & FUNCTION, vol. 11, pp. 10423-10435, ISSN:2042-6496 DOI Accesso ONLINE all'editore

Arena C.; Gado F.; Di Cesare Mannelli L.; Cervetto C.; Carpi S.; Reynoso-Moreno I.; Polini B.; Vallini E.; Chicca S.; Lucarini E.; Bertini S.; D'Andrea F.; Digiacomo M.; Poli G.; Tuccinardi T.; Macchia M.; Gertsch J.; Marcoli M.; Nieri P.; Ghelardini C.; Chicca A.; Manera C. (2020). The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 208, pp. 112858-112858, ISSN:0223-5234 DOI

Parisio C.; Lucarini E.; Micheli L.; Toti A.; Mannelli L.D.C.; Antonini G.; Panizzi E.; Maidecchi A.; Giovagnoni E.; Lucci J.; Ghelardini C. (2020). Researching new therapeutic approaches for abdominal visceral pain treatment: Preclinical effects of an assembled system of molecules of vegetal origin. NUTRIENTS, vol. 12, pp. 0-0, ISSN:2072-6643 DOI

De Caro, Carmen; Di Cesare Mannelli, Lorenzo; Branca, Jacopo Junio Valerio; Micheli, Laura; Citraro, Rita; Russo, Emilio; De Sarro, Giovambattista; Ghelardini, Carla; Calignano, Antonio; Russo, Roberto (2020). Pain Modulation in WAG/Rij Epileptic Rats (A Genetic Model of Absence Epilepsy): Effects of Biological and Pharmacological Histone Deacetylase Inhibitors. FRONTIERS IN PHARMACOLOGY, vol. 11, pp. 0-0, ISSN:1663-9812 DOI

Luca Antonioli 1, Elena Lucarini , Catia Lambertucci 3, Matteo Fornai 1, Carolina Pellegrini 4, Laura Benvenuti 1, Lorenzo Di Cesare Mannelli, Andrea Spinaci 3, Gabriella Marucci 3, Corrado Blandizzi 1, Carla Ghelardini, Rosaria Volpini 3, Diego Dal Ben 3 (2020). The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A 3 Receptor Agonist, in a Rat Model of Colitis. CELLS, pp. 1509-1509, ISSN:2073-4409

Testai L.; Piragine E.; Piano I.; Flori L.; Da Pozzo E.; Miragliotta V.; Pirone A.; Citi V.; Di Cesare Mannelli L.; Brogi S.; Carpi S.; Martelli A.; Nieri P.; Martini C.; Ghelardini C.; Gargini C.; Calderone V. (2020). The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, vol. 2020, pp. 4650207-15, ISSN:1942-0900 DOI

Piragine E.; Flori L.; Di Cesare Mannelli L.; Ghelardini C.; Pagnotta E.; Matteo R.; Lazzeri L.; Martelli A.; Miragliotta V.; Pirone A.; Testai L.; Calderone V. (2020). Eruca sativa Mill. seed extract promotes anti-obesity and hypoglycemic effects in mice fed with a high-fat diet. PHYTOTHERAPY RESEARCH, pp. 0-0, ISSN:0951-418X DOI

Arias H.R.; Ghelardini C.; Lucarini E.; Tae H.-S.; Yousuf A.; Marcovich I.; Manetti D.; Romanelli M.N.; Elgoyhen A.B.; Adams D.J.; Di Cesare Mannelli L. (2020). (E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation. ACS CHEMICAL NEUROSCIENCE, vol. 11, pp. 3603-3614-3614, ISSN:1948-7193 DOI

Consalvi S.; Poce G.; Ghelardini C.; Di Cesare Mannelli L.; Patrignani P.; Bruno A.; Anzini M.; Calderone V.; Martelli A.; Testai L.; Giordani A.; Biava M. (2020). Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0223-5234 DOI

Lucarini, E; Coppi, E; Micheli, L; Parisio, C; Vona, A; Cherchi, F; Pugliese, AM; Pedata, F; Failli, P; Palomino, S; Wahl, J; Largent-Milnes, TM; Vanderah, TW; Tosh, DK; Jacobson, KA; Salvemini, D; Ghelardini, C; Mannelli, LD (2020). Acute visceral pain relief mediated by A(3)AR agonists in rats: involvement of N-type voltage-gated calcium channels. PAIN, vol. 161, pp. 2179-2190, ISSN:0304-3959 DOI

Bedini A.; Di Cesare Mannelli L.; Micheli L.; Baiula M.; Vaca G.; De Marco R.; Gentilucci L.; Ghelardini C.; Spampinato S. (2020). Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. FRONTIERS IN PHARMACOLOGY, vol. 11, pp. 0-0, ISSN:1663-9812 DOI

Micheli L.; Spitoni S.; Di Cesare Mannelli L.; Bilia A.R.; Ghelardini C.; Pallanti S. (2020). Bacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation. PHYTOTHERAPY RESEARCH, vol. 34, pp. 2331-2340, ISSN:0951-418X DOI

Arias H.R.; Tae H.-S.; Micheli L.; Yousuf A.; Ghelardini C.; Adams D.J.; Di Cesare Mannelli L. (2020). Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels. NEUROPHARMACOLOGY, vol. 175, pp. 0-0, ISSN:0028-3908 DOI

Caputi F.F.; Di Cesare Mannelli L.; Rullo L.; Micheli L.; Stamatakos S.; Posa L.; Ghelardini C.; Romualdi P.; Candeletti S. (2020). The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms. BIOCHEMICAL PHARMACOLOGY, vol. 182, pp. 0-0, ISSN:0006-2952 DOI

Micheli L.; Mannelli L.D.C.; Mattoli L.; Tamimi S.; Flamini E.; Garetto S.; Lucci J.; Giovagnoni E.; Cinci L.; D'ambrosio M.; Luceri C.; Ghelardini C. (2020). Intra-articular route for the system of molecules 14g1862 from centella asiatica: Pain relieving and protective effects in a rat model of osteoarthritis. NUTRIENTS, vol. 12, pp. 0-0, ISSN:2072-6643 DOI

Parisio C.; Lucarini E.; Micheli L.; Toti A.; Khatib M.; Mulinacci N.; Calosi L.; Bani D.; Mannelli L.D.C.; Ghelardini C. (2020). Pomegranate mesocarp against colitis-induced visceral pain in rats: Effects of a decoction and its fractions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, pp. 1-16, ISSN:1661-6596 DOI

Micheli L.; Di Cesare Mannelli L.; Del Bello F.; Giannella M.; Piergentili A.; Quaglia W.; Carrino D.; Pacini A.; Ghelardini C. (2020). The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity. NEUROTHERAPEUTICS, pp. 0-0, ISSN:1933-7213 DOI

Di Capua A, Reale A, Paolino M, Chemi G, Brogi S, Cappelli A, Giorgi G, Grande F, Di Cesare Mannelli L, Ghelardini C, Matucci R, Garofalo A, Anzini M. (2020). Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 200, pp. 1-11, ISSN:1768-3254 Accesso ONLINE all'editore

Alfonsina D’Amato, Lorenzo Di Cesare-Mannelli, Elena Lucarini, Angela L. Man, Gwenaelle Le Gall, Jacopo Branca, Carla Ghelardini, Amedeo Amedei, Eugenio Bertelli, Mari Regoli, Alessandra Pacini, Giulia Luciani, Pasquale Gallina, Annalisa Altera, Arjan Narbad, Massimo Gulisano, Lesley Hoyles, David Vauzour4, Claudio Nicoletti (2020). Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients. MICROBIOME, vol. 8, pp. 1-19, ISSN:2049-2618 DOI

Crocetti L.; Vergelli C.; Guerrini G.; Cantini N.; Kirpotina L.N.; Schepetkin I.A.; Quinn M.T.; Parisio C.; Di Cesare Mannelli L.; Ghelardini C.; Giovannoni M.P. (2020). Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis. BIOORGANIC CHEMISTRY, vol. 100, pp. 1-12, ISSN:0045-2068 DOI

Laura Micheli, Alessandra Pacini, Lorenzo Di Cesare Mannelli, Elena Trallori, Carla Ghelardini (2020). Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation.. NUTRIENTS, vol. 12, pp. 1819-1842, ISSN:2072-6643 DOI

Maestrelli, Francesca; González-Rodríguez, María Luisa; Fernández-Romero, Ana-María; Mura, Paola Angela; Rabasco, Antonio M.; Micheli, Laura; Mannelli, Lorenzo Di Cesare; Ghelardini, Carla (2020). Curcumin-in-Cyclodextrins-in-Liposomes: An Alternative for Osteoarthritis Treatment. PROCEEDINGS, vol. 78, pp. 0-0, ISSN:2504-3900 DOI Accesso ONLINE all'editore

Lucarini E.; Parisio C.; Branca J.J.V.; Segnani C.; Ippolito C.; Pellegrini C.; Antonioli L.; Fornai M.; Micheli L.; Pacini A.; Bernardini N.; Blandizzi C.; Ghelardini C.; Di Cesare Mannelli L. (2020). Deepening the Mechanisms of Visceral Pain Persistence: An Evaluation of the Gut-Spinal Cord Relationship. CELLS, vol. 9, pp. 0-0, ISSN:2073-4409 DOI

Bua S.; Lucarini L.; Micheli L.; Menicatti M.; Bartolucci G.; Selleri S.; Di Cesare Mannelli L.; Ghelardini C.; Masini E.; Carta F.; Gratteri P.; Nocentini A.; Supuran C.T. (2020). Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 63, pp. 2325-2342, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Soleimanian, Yasamin; Goli, Sayed Amir Hossein; Varshosaz, Jaleh; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Cirri, Marzia; Maestrelli, Francesca (2020). β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity. PHARMACEUTICS, vol. 12, pp. 0-0, ISSN:1999-4923 DOI Accesso ONLINE all'editore

Cirri, Marzia; Maestrelli, Francesca; Mennini, Natascia; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Ghelardini, Carla; Mura, Paola (2020). Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of cyclodextrins and hydrophilic polymers. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 587, pp. 119692-119692, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Laura Micheli, Murat Bozdag , Ozlem Akgul , Fabrizio Carta , Clizia Guccione, Maria Camilla Bergonzi, Anna Rita Bilia, Lorenzo Cinci, Elena Lucarini, Carmen Parisio, Claudiu T. Supuran , Carla Ghelardini, Lorenzo Di Cesare Mannelli (2019). Pain Relieving Eect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, pp. 0-0, ISSN:1422-0067

Martelli A, Piragine E, Citi V, Testai L, Pagnotta E, Ugolini L, Lazzeri L, Di Cesare Mannelli L, Manzo OL, Bucci M, Ghelardini C, Breschi MC, Calderone V (2019). Erucin exhibits vasorelaxing effects and antihypertensive activity by H2 S-releasing properties. BRITISH JOURNAL OF PHARMACOLOGY, pp. 0-0, ISSN:0007-1188 DOI

Micheli L, Lucarini E, Trallori E, Avagliano C, De Caro C, Russo R, Calignano A, Ghelardini C, Pacini A, Di Cesare Mannelli L. (2019). Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice .. NUTRIENTS, vol. 11, pp. 1778-1797, ISSN:2072-6643 DOI

Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Dal Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Colotta, Vittoria* (2019). Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells. BIOORGANIC CHEMISTRY, vol. 87, pp. 380-394, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Domazetovic V, Marcucci G, Pierucci F, Bruno G, Di Cesare Mannelli L, Ghelardini C, Brandi ML, Iantomasi T, Meacci E, Vincenzini MT. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1. FEBS OPENBIO, vol. 9 (6), pp. 1082-1096, ISSN:2211-5463, Wiley Blackwell: DOI Accesso ONLINE all'editore

Lucarini E, Pagnotta E, Micheli L, Parisio C, Testai L, Martelli A, Calderone V, Matteo R, Lazzeri L, Di Cesare Mannelli L, Ghelardini C (2019). Eruca sativa Meal against Diabetic Neuropathic Pain: An H2S-Mediated Effect of Glucoerucin. MOLECULES, pp. 0-0, ISSN:1420-3049 DOI

Andrea Angeli; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Thomas S. Peat; Gianluca Bartolucci; Marta Menicatti; Fabrizio Carta; Claudiu T. Supuran (2019). Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases {II} and {VII} and show neuropathic pain attenuating effects. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 177, pp. 188-197, ISSN:1768-3254 DOI

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Varani, Katia; Vincenzi, Fabrizio; Pasquini, Silvia; di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Lucarini, Elena; Dal Ben, Diego; Spinaci, Andrea; Bartolucci, Gian Luca; Menicatti, Marta; Colotta, Vittoria (2019). Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 6894-6912, ISSN:0022-2623 DOI

Falsini M.; Catarzi D.; Varano F.; Ceni C.; Dal Ben D.; Marucci G.; Buccioni M.; Volpini R.; Di Cesare Mannelli L.; Lucarini E.; Ghelardini C.; Bartolucci G.; Menicatti M.; Colotta V. (2019). Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 8511-8531, ISSN:1520-4804 DOI

Micheli L.; Bozdag M.; Akgul O.; Carta F.; Guccione C.; Bergonzi M.C.; Bilia A.R.; Cinci L.; Lucarini E.; Parisio C.; Supuran C.T.; Ghelardini C.; Di Cesare Mannelli L. (2019). Pain relieving effect of-NSAIDS-CAIs hybrid molecules: Systemic and intra-articular treatments against rheumatoid arthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1923-1938, ISSN:1422-0067 DOI Accesso ONLINE all'editore

Angeli A.; Di Cesare Mannelli L.; Ghelardini C.; Peat T.S.; Bartolucci G.; Menicatti M.; Carta F.; Supuran C.T. (2019). Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 177, pp. 188-197, ISSN:1768-3254 DOI Accesso ONLINE all'editore

Dina Manetti*† , Alexandra Garifulina‡, Gian Luca Bartolucci , Carla Bazzicalupi§ , Cristina Bellucci†, Niccolò Chiaramonte†, Silvia Dei†, Lorenzo Di Cesare Mannelli∥, Carla Ghelardini∥, Paola Gratteri⊥ , Ekaterina Spirova‡, Irina Shelukhina‡, Elisabetta Teodori†, Katia Varani#, Victor Tsetlin‡, Maria Novella Romanelli† (2019). New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 1887-1901, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Bozdag M.; Poli G.; Angeli A.; Lucarini E.; Tuccinardi T.; Di Cesare Mannelli L.; Selleri S.; Ghelardini C.; Winum J.-Y.; Carta F.; Supuran C.T. (2019). N-aryl-N’-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties. BIOORGANIC CHEMISTRY, vol. 89, pp. 103033-103043, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Tanini, Damiano; Ricci, Lorenzo; Capperucci, Antonella; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Peat, Thomas S; Carta, Fabrizio; Angeli, Andrea; Supuran, Claudiu T (2019). Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 181, pp. 111586-111594, ISSN:1768-3254 DOI

Berrino E.; Milazzo L.; Micheli L.; Vullo D.; Angeli A.; Bozdag M.; Nocentini A.; Menicatti M.; Bartolucci G.; Di Cesare Mannelli L.; Ghelardini C.; Supuran C.T.; Carta F. (2019). Synthesis and evaluation of carbonic anhydrase inhibitors with carbon monoxide releasing properties for the management of rheumatoid arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 7233-7249, ISSN:1520-4804 DOI

Kalisha Vali Y.; Gundla R.; Singh O.V.; Tamboli Y.; Di Cesare Manelli L.; Ghelardini C.; Al-Tamimi A.-M.S.; Carta F.; Angeli A.; Supuran C.T. (2019). Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity. BIOORGANIC CHEMISTRY, vol. 92, pp. 103210-103220, ISSN:0045-2068 DOI Accesso ONLINE all'editore

Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C (2019). Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, pp. 276-287, ISSN:0022-2623 DOI

Branca J.J.V.; Morucci G.; Becatti M.; Carrino D.; Ghelardini C.; Gulisano M.; Di Cesare Mannelli L.; Pacini A. (2019). Cannabidiol protects dopaminergic neuronal cells from cadmium. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol. 16, pp. 0-0, ISSN:1660-4601 DOI Accesso ONLINE all'editore

Bonfiglio T, Olivero G, Vergassola M, Di Cesare Mannelli L, Pacini A, Iannuzzi F, Summa M, Bertorelli R, Feligioni M, Ghelardini C, Pittaluga A. (2019). Environmental training is beneficial to clinical symptoms and cortical presynaptic defects in mice suffering from experimental autoimmune encephalomyelitis.. NEUROPHARMACOLOGY, vol. 145, pp. 75-86, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Coppi, Elisabetta; Cherchi, Federica; Fusco, Irene; Failli, Paola; Vona, Alessia; Dettori, Ilaria; Gaviano, Lisa; Lucarini, Elena; Jacobson, Kenneth A; Tosh, Dilip K; Salvemini, Daniela; Ghelardini, Carla; Pedata, Felicita; Di Cesare Mannelli, Lorenzo; Pugliese, Anna Maria (2019). Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons. PAIN, pp. 1-16, ISSN:0304-3959 DOI

Carmen De Caro, Antonio Leo, Valentina Nesci, Carla Ghelardini, Lorenzo di Cesare Mannelli, Pasquale Striano, Carmen Avagliano, Antonio Calignano, Paolo Mainardi, Andrew Constanti, Rita Citraro, Giovambattista De Sarro, and Emilio Russo (2019). Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.. SCIENTIFIC REPORTS, vol. 9, pp. 0-0, ISSN:2045-2322 DOI

Elena Trallori, Carla Ghelardini, Lorenzo Di Cesare Mannelli (2019). Mesenchymal stem cells, implications for pain therapy.. NEURAL REGENERATION RESEARCH, pp. 0-0, ISSN:1673-5374 DOI

Reale A, Brogi S, Chelini A, Paolino M1, Di Capua A, Giuliani G, Cappelli A, Giorgi G, Chemi G, Grillo A, Valoti M, Sautebin L, Rossi A, Pace S, La Motta C, Di Cesare Mannelli L, Lucarini E, Ghelardini C, Anzini M (2019). Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold. BIOORGANIC & MEDICINAL CHEMISTRY, pp. 0-0, ISSN:0968-0896 DOI

Recinella L, Chiavaroli A, Orlando G, Menghini L, Ferrante C, Di Cesare Mannelli L, Ghelardini C, Brunetti L, Leone S (2019). Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS.. MOLECULES, pp. 0-0, ISSN:1420-3049 DOI

Branca J.J.V. , Maresca M. , Morucci G. , Mello T. , Becatti M. , Pazzagli L. , Colzi I. , Gonnelli C. , Carrino D. , Paternostro F. , Nicoletti C. , Ghelardini C. , Gulisano M. , Di Cesare Mannelli L. , Pacini A. (2019). Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, pp. 1-19, ISSN:1422-0067 DOI

Piazzini, Vieri; Micheli, Laura; Luceri, Cristina; D'Ambrosio, Mario; Cinci, Lorenzo; Ghelardini, Carla; Rita Bilia, Anna; Di Cesare Mannelli, Lorenzo; Camilla Bergonzi, Maria (2019). Nanostructured lipid carriers for oral delivery of silymarin: improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. ---, pp. 0-0, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Citi V, Piragine E, Pagnotta E, Ugolini L, Di Cesare Mannelli L, Testai L, Ghelardini C, Lazzeri L, Calderone V, Martelli A (2019). Anticancer properties of erucin, an H2 S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1).. PHYTOTHERAPY RESEARCH, pp. 0-0, ISSN:0951-418X DOI

Micheli L, Ghelardini C, Lucarini E, Parisio C, Trallori E, Cinci L, Di Cesare Mannelli L (2019). Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.. JOURNAL OF PHARMACY AND PHARMACOLOGY, pp. 971-981, ISSN:0022-3573 DOI

Micheli L, Cialdai F, Pacini A, Branca JJV, Morbidelli L, Ciccone V, Lucarini E, Ghelardini C, Monici M, Di Cesare Mannelli L (2019). Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis.. SCIENTIFIC REPORTS, vol. 9, pp. 9297-9306, ISSN:2045-2322 DOI

Marzia Cirri, Francesca Maestrelli , Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Combined Approach of Cyclodextrin Complexation and Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide. PHARMACEUTICS, vol. 10, pp. 0-0, ISSN:1999-4923 DOI

Lucarini E, Micheli L, Martelli A, Testai L, Calderone V, Ghelardini C, Di Cesare Mannelli L (2018). Efficacy of isothiocyanate-based compounds on different forms of persistent pain.. JOURNAL OF PAIN RESEARCH, pp. 2905-2913, ISSN:1178-7090 DOI

Dini, Leonardo; Del Lungo, Martina; Resta, Francesco; Melchiorre, Michele; Spinelli, Valentina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Laurino, Annunziatina; Sartiani, Laura; Coppini, Raffaele; Mannaioni, Guido; Cerbai, Elisabetta; Romanelli, Maria Novella (2018). Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain. FRONTIERS IN PHARMACOLOGY, vol. 9, pp. 1252-1252, ISSN:1663-9812 DOI

Dietis N; Niwa H; Tose R; McDonald J; Ruggieri V; Filaferro M; Vitale G; Micheli L;Ghelardini C;Salvadori S; Calo G; Guerrini R; Rowbotham DJ; Lambert DG (2018). In vitro and in vivo characterization of the bifunctional u and o opioid receptor ligand UFP-505. BRITISH JOURNAL OF PHARMACOLOGY, pp. 2881-2896, ISSN:1476-5381 DOI

Francesca Cantini, Vito Calderone, Lorenzo Di Cesare Mannelli, Magdalena Korsak, Leonardo Gonnelli, Oscar Francesconi, Carla Ghelardini, Lucia Banci, and Cristina Nativi (2018). Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 1094-1098, ISSN:1948-5875 DOI

Micheli L., Mattoli L., Maidecchi A., Pacini A., Ghelardini C., Di Cesare Mannelli L. (2018). Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence. SCIENTIFIC REPORTS, vol. 8, pp. 14364-14377, ISSN:2045-2322 DOI Accesso ONLINE all'editore

Branca J.J.V. , Maresca M., Morucci G., Becatti M., Paternostro F., Gulisano M., Ghelardini C., Salvemini D., Di Cesare Mannelli L., Pacini A. (2018). OXALIPLATIN-INDUCED BLOOD BRAIN BARRIER LOOSENING: A NEW POINT OF VIEW ON CHEMOTHERAPY-INDUCED NEUROTOXICITY. ONCOTARGET, vol. 9, pp. 23426-23438, ISSN:1949-2553 DOI

Di Cesare Mannelli L, Micheli L, Lucarini E, Ghelardini C (2018). Ultramicronized N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception. FRONTIERS IN PHARMACOLOGY, pp. 0-0, ISSN:1663-9812 DOI

Marzia Cirri , Lavinia Maestrini , Francesca Maestrelli , Natascia Mennini , Paola Mura , Carla Ghelardini, Lorenzo Di Cesare Mannelli (2018). Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy. DRUG DELIVERY, vol. 25, pp. 1910-1921, ISSN:1521-0464 DOI Accesso ONLINE all'editore

Bragagni M, Gil-Alegre ME, Mura P, Cirri M, Ghelardini C, Di Cesare Mannelli L (2018). Improving the therapeutic efficacy of prilocaine by PLGA microparticles: Preparation, characterization and in vivo evaluation.. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 24-30, ISSN:0378-5173 DOI

Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT (2018). 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, pp. 10860-10874, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, di Marzo V, Butini S, Gemma S (2018). Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. CHEMMEDCHEM, pp. 2090-2103, ISSN:1860-7187 DOI

Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT (2018). Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, pp. 210-219, ISSN:0223-5234 DOI

Lucarini E, Micheli L, Trallori E, Citi V, Martelli A, Testai L, De Nicola G, Iori R, Calderone V, Ghelardini C, Di Cesare Mannelli L (2018). Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2 S release in vivo.. PHYTOTHERAPY RESEARCH, pp. 2226-2234, ISSN:1099-1573 DOI

Di Cesare Mannelli L, Piccolo M, Maione F, Ferraro MG, Irace C, De Feo V, Ghelardini C, Mascolo N (2018). Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy. BIOMÉDECINE & PHARMACOTHÉRAPIE, pp. 1042-1049, ISSN:0753-3322 DOI

Angeli, Andrea; Di Cesare Mannelli, Lorenzo; Trallori, Elena; Peat, Thomas S.; Ghelardini, Carla; Carta, Fabrizio; Supuran, Claudiu T.* (2018). Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 462-467, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Angeli, Andrea; Trallori, Elena; Ferraroni, Marta; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Supuran, Claudiu T.* (2018). Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, pp. 1214-1222, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Branca, Jacopo J V; Morucci, Gabriele; Maresca, Mario; Tenci, Barbara; Cascella, Roberta; Paternostro, Ferdinando; Ghelardini, Carla; Gulisano, Massimo; Di Cesare Mannelli, Lorenzo; Pacini, Alessandra (2018). Selenium and zinc: Two key players against cadmium-induced neuronal toxicity.. TOXICOLOGY IN VITRO, vol. 48, pp. 159-169, ISSN:0887-2333 DOI

Resta, F.*; Micheli, L.; Laurino, A.; Spinelli, V.; Mello, T.; Sartiani, L.; Di Cesare Mannelli, L.; Cerbai, E.; Ghelardini, C.; Romanelli, M.N.; Mannaioni, G.; Masi, A. (2018). Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy. NEUROPHARMACOLOGY, vol. 131, pp. 403-413, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Aghazadeh Tabrizi, M; Baraldi, Pg; Baraldi, S; Ruggiero, E; De Stefano, L; Rizzolio, F; Di Cesare Mannelli, L; Ghelardini, C; Chicca, A; Lapillo, M; Gertsch, J; C, Manera; Macchia, M; Martinelli, A; Granchi, C; Minutolo, F; Tuccinardi, T. (2018). Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, pp. .1340-.1354, ISSN:0022-2623 DOI

Micheli L, Lucarini E, Corti F, Ciccocioppo r, Calò G, Rizzi A, Ghelardini C, Di Cesare Mannelli L. (2018). Involvement of the N/OFQ-NOP system in rat morphine antinociceptive tolerance: Are astrocytes the crossroad?. EUROPEAN JOURNAL OF PHARMACOLOGY, pp. 79-86, ISSN:0014-2999 DOI

Menicatti, Marta; Pallecchi, Marco; Bua, Silvia; Vullo, Daniela; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Carta, Fabrizio; Supuran, Claudiu T.; Bartolucci, Gianluca* (2018). Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 33, pp. 671-679, ISSN:1475-6366 DOI

Akgul, Ozlem; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Angeli, Andrea; Ghelardini, Carla; Bartolucci, Gianluca; Altamimi, Abdulmalik Saleh Alfawaz; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2018). Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, pp. 1-60, ISSN:0022-2623 DOI

Tomassoni D, Di Cesare Mannelli L, Bramanti V, Ghelardini C, Amenta F, Pacini A (2018). TREATMENT WITH ACETYL-L-CARNITINE EXERTS A NEUROPROTECTIVE EFFECT IN THE SCIATIC NERVE FOLLOWING LOOSE LIGATION: A FUNCTIONAL AND MICROANATOMICAL STUDY. NEURAL REGENERATION RESEARCH, vol. 13, pp. 692-698, ISSN:1673-5374 DOI

Angeli, Andrea; Trallori, Elena; Carta, Fabrizio; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Supuran, Claudiu T.* (2018). Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines. ACS MEDICINAL CHEMISTRY LETTERS, vol. 9, pp. 947-951, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Alessia Costa, Claudia Cristiano, Tommaso Cassano, Cristina Anna Gallelli, Silvana Gaetani, Carla Ghelardini, Patrizio Blandina, Antonio Calignano, Maria Beatrice Passani, Gustavo Provensi (2018). Histamine-deficient mice do not respond to the antidepressant-like effects of oleoylethanolamide. NEUROPHARMACOLOGY, vol. 135, pp. 234-241, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Bonardi, Alessandro; Falsini, Matteo; Catarzi, Daniela; Varano, Flavia; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria* (2018). Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 146, pp. 47-59, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Bonfiglio, T; Olivero, G; Merega, E; Di Prisco, S; Padolecchia, C; Grilli, M; Milanese, M; Di Cesare Mannelli, L; Ghelardini, C; Bonanno, G; Marchi, M; Pittaluga, A. (2017). Prophylactic versus Therapeutic Fingolimod: Restoration of Presynaptic Defects in Mice Suffering from Experimental Autoimmune Encephalomyelitis. PLOS ONE, pp. e0170825-e0170825, ISSN:1932-6203 DOI

Fragai, Marco; Comito, Giuseppina; Di Cesare Mannelli, Lorenzo; Gualdani, Roberta; Calderone, Vito; Louka, Alexandra; Richichi, Barbara; Francesconi, Oscar; Angeli, Andrea; Nocentini, Alessio; Gratteri, Paola; Chiarugi, Paola; Ghelardini, Carla; Tadini-Buoninsegni, Francesco; Supuran, Claudiu T; Nativi, Cristina (2017). Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9003-9011, ISSN:1520-4804 DOI

Di Cesare Mannelli, L; Pacini, A; Micheli, L; Femia, Ap; Maresca, M; Zanardelli, M; Vannacci, A; Gallo, E; Bilia, Ar; Caderni, G; Firenzuoli, F; Mugelli, A; Ghelardini, C (2017). Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?. SCIENTIFIC REPORTS, vol. 7, pp. 1-13, ISSN:2045-2322 DOI

Tenci, B; Di Cesare Mannelli, L; Maresca, M; Micheli, L; Pieraccini, G; Mulinacci, N; Ghelardini, C. (2017). Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats. ZEITSCHRIFT FUR NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, pp. 449-457, ISSN:1865-7125 DOI

Di Cesare Mannelli, L; Ghelardini, C; Micheli, L; Del Bello, F; Giannella, M; Piergentili, A; Pigini, M; Quaglia, W. (2017). Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives. EUROPEAN JOURNAL OF PHARMACOLOGY, pp. 128-133, ISSN:0014-2999 DOI

Di Cesare Mannelli, L; Ghelardini, C. (2017). Neurorestoration from medicinal plants: an opportunity to treat painful neuropathies. NEURAL REGENERATION RESEARCH, pp. 403-404, ISSN:1673-5374 DOI

Maresca, M; Micheli, L; Cinci, L; Bilia, Ar; Ghelardini, C; Di Cesare Mannelli, L. (2017). Pain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models. JOURNAL OF PHARMACY AND PHARMACOLOGY, pp. 1858-1870, ISSN:0022-3573 DOI

Micheli, L; Di Cesare Mannelli, L; Lucarini, E; Cialdai, F; Vignali, L; Ghelardini, C; Monici, M. (2017). Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat. LASERS IN MEDICAL SCIENCE, pp. 1835-1846, ISSN:1435-604X DOI

Di Cesare Mannelli, L; Tenci, B; Micheli, L; Vona, A; Corti, F; Zanardelli, M; Lapucci, A; Clemente, Am; Failli, P; Ghelardini, C. (2017). Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation. NEUROPHARMACOLOGY, pp. 166-175, ISSN:1873-7064 DOI

Di Cesare Mannelli, L; Lucarini, E; Micheli, L; Mosca, I; Ambrosino, P; Soldovieri, Mv; Martelli, A; Testai, L; Taglialatela, M; Calderone, V; Ghelardini, C. (2017). Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels. NEUROPHARMACOLOGY, pp. 49-59, ISSN:1873-7064 DOI

Chelini, A; Brogi, S; Paolino, M; Di Capua, A; Cappelli, A; Giorgi, G; Farzad, M; Di Cesare Mannelli, L; Micheli, L; Ghelardini, C; Anzini, (2017). Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators. JOURNAL OF MEDICINAL CHEMISTRY, pp. 5216-5221, ISSN:0022-2623 DOI

Romero, Hk; Christensen, Sb; Di Cesare Mannelli, L; Gajewiak, J; Ramachandra, R; Elmslie, Ks; Vetter, De; Ghelardini, C; Iadonato, Sp; Mercado, Jl; Olivera, Bm; Mcintosh, Jm (2017). Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, pp. 1825-1832, ISSN:0027-8424 DOI

Cinci, L; Di Cesare Mannelli, L; Maidecchi, A; Mattoli, L; Ghelardini, C. (2017). Effects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations. ZEITSCHRIFT FÜR NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, pp. 219-226, ISSN:0939-5075 DOI

Isacchi, Benedetta; Bergonzi, Maria Camilla; Iacopi, Romina; Ghelardini, Carla; Galeotti, Nicoletta; Bilia, Anna Rita (2017). Liposomal Formulation to Increase Stability and Prolong Antineuropathic Activity of Verbascoside. PLANTA MEDICA, vol. 83, pp. 412-419, ISSN:0032-0943 DOI

Maestrelli, Francesca; Mura, Paola; Cirri, Marzia; Mennini, Natascia; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2017). Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays. INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0-0, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria (2017). 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 6428-6439, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Angeli, Andrea; Tanini, Damiano; Peat, Thomas S. ; Di Cesare Mannelli,Lorenzo; Bartolucci, Gian Luca; Capperucci, Antonella; Ghelardini, Carla; Supuran, Claudiu T.; and Carta, Fabrizio (2017). Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 963-968, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Nocentini, Alessio; Bua, Silvia; Lomelino, Carrie L.; Mckenna, Robert; Menicatti, Marta; Bartolucci, Gianluca; Tenci, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Gratteri, Paola; Supuran, Claudiu T. (2017). Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases. ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, pp. 1314-1319, ISSN:1948-5875 DOI Accesso ONLINE all'editore

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, MARIA PAOLA; Iacovone, Antonella; DI CESARE MANNELLI, Lorenzo; Martini, Claudia; Vergelli, Claudia (2017). Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 9691-9702, ISSN:0022-2623 DOI

Lorenzo Di Cesare Mannelli, ; Mario, Maresca; Laura, Micheli; Carlo, Farina; Michael, W; Carla, Ghelardini (2017). A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin. CANCER CHEMOTHERAPY AND PHARMACOLOGY, pp. 1091-1103, ISSN:0344-5704 DOI

Gabriella, Guerrini; Ciciani, Giovanna; Daniele, Simona; lorenzo di cesare mannelli, ; Ghelardini, Carla; Martini, Claudia; Silvia, Selleri (2017). Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1901-1906, ISSN:0968-0896 DOI

Martino, Maria Vittoria; Guandalini, Luca; Di Cesare Mannelli, Lorenzo; Menicatti, Marta; Bartolucci, Gianluca; Dei, Silvia; Manetti, Dina; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2017). Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, pp. 1795-1803, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2017). Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 798, pp. 85-93, ISSN:0014-2999 DOI

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2017). HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury. BRAIN RESEARCH, vol. 1659, pp. 55-63, ISSN:1872-6240 DOI

Cirri, Marzia; Mennini, Natascia; Maestrelli, Francesca; Mura, Paola; Ghelardini, Carla; di Cesare Mannelli, Lorenzo (2017). Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 521, pp. 73-83, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Bua, Silvia; Di Cesare Mannelli, Lorenzo; Vullo, Daniela; Ghelardini, Carla; Bartolucci, Gianluca; Scozzafava, Andrea; Supuran, Claudiu T; Carta, Fabrizio (2017). Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 1159-1170, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Maestrelli, F; Mura, P; González-Rodríguez, Ml; Cózar-Bernal, Mj; Rabasco, Am; Di Cesare Mannelli, L; Ghelardini, C. (2017). Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 530, pp. 430-439, ISSN:0378-5173 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2017). St. John's Wort Potentiates anti-Nociceptive Effects of Morphine in Mice Models of Neuropathic Pain. PAIN MEDICINE, vol. 18, pp. 1334-1343, ISSN:1526-2375 DOI

Sanna, Maria Domenica; Lucarini, Laura; Durante, Mariaconcetta; Ghelardini, Carla; Masini, Emanuela; Galeotti, Nicoletta (2017). Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. BRITISH JOURNAL OF PHARMACOLOGY, vol. 174, pp. 28-40, ISSN:0007-1188 DOI

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Crocetti, Letizia; Giovannoni, Maria Paola; Vergelli, Claudia; Ghelardini, Carla (2017). α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 16, pp. 95-107, ISSN:1875-5607 DOI

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2017). Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression. BRAIN RESEARCH BULLETIN, vol. 128, pp. 1-6, ISSN:0361-9230 DOI

Sanna, Maria Domenica; Ghelardini, Carla; Thurmond, Robin L.; Masini, Emanuela; Galeotti, Nicoletta (2017). Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions. NEUROPHARMACOLOGY, vol. 114, pp. 48-57, ISSN:0028-3908 DOI

Guerrini, Gabriella; Ciciani, Giovanna; Crocetti, Letizia; Daniele, Simona; Ghelardini, Carla; Giovannoni, Maria Paola; Lorenzo Di Cesare Mannelli, ; Martini, Claudia; Vergelli, Claudia (2017). Synthesis and pharmacological evaluation of novel GABAA subtype receptor ligands with potential anxiolytic-like and anti-hyperlagesic effect. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 54, pp. 2788-2799, ISSN:1943-5193 DOI

Di Capua, Angela; Sticozzi, Claudia; Brogi, Simone; Brindisi, Margherita; Cappelli, Andrea; Sautebin, Lidia; Rossi, Antonietta; Pace, Simona; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Valacchi, Giuseppe; Giorgi, Gianluca; Giordani, Antonio; Poce, Giovanna; Biava, Mariangela; Anzini, Maurizio (2016). Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 109, pp. 99-106, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2016). Altered Expression of Cytoskeletal and Axonal Proteins in Oxaliplatin-Induced Neuropathy. PHARMACOLOGY, vol. 97, pp. 146-150, ISSN:0031-7012 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2016). Blockade of the spinal BDNF-activated JNK pathway prevents the development of antiretroviral-induced neuropathic pain. NEUROPHARMACOLOGY, vol. 105, pp. 543-552, ISSN:0028-3908 DOI

Di Cesare Mannelli, L; Micheli, L; Cinci, L; Maresca, M; Vergelli, C; Pacini, A; Quinn, M.T.; Giovannoni, M. P.; Ghelardini, C. (2016). Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis.. RHEUMATOLOGY, vol. 55, pp. 1285-1294, ISSN:1462-0332 DOI

Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Landini, Ida; Pacini, Alessandra; Ghelardini, Carla; Mini, Enrico; Bencini, Andrea; Valtancoli, Barbara; Failli, Paola (2016). Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy. FREE RADICAL BIOLOGY & MEDICINE, vol. 93, pp. 67-76, ISSN:0891-5849 DOI

Testai, Lara; Marino, Alice; Piano, Ilaria; Brancaleone, Vincenzo; Tomita, Kengo; Di Cesare Mannelli, Lorenzo; Martelli, Alma; Citi, Valentina; Breschi, Maria C.; Levi, Roberto; Gargini, Claudia; Bucci, Mariarosaria; Cirino, Giuseppe; Ghelardini, Carla; Calderone, Vincenzo (2016). The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. PHARMACOLOGICAL RESEARCH, vol. 113, pp. 290-299, ISSN:1043-6618 DOI Accesso ONLINE all'editore

Sanna, M.D.; Peroni, D.; Mello, T.; Ghelardini, C.; Quattrone, A.; Galeotti, N (2016). Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD. PHARMACOLOGICAL RESEARCH, vol. 111, pp. 23-33, ISSN:1043-6618 DOI Accesso ONLINE all'editore

Consalvi, Sara; Poce, Giovanna; Ragno, Rino; Sabatino, Manuela; Lamotta, Concettina; Sartini, Stefania; Calderone, Vincenzo; Martelli, Alma; Ghelardini, Carla; DI CESARE MANNELLI, Lorenzo; Biava, Mariangela (2016). A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis. CHEMMEDCHEM, vol. 11, pp. 1804-1811, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Maresca, Mario; Cravotto, Giancarlo; Bellumori, Maria; Innocenti, Marzia; Mulinacci, Nadia; Ghelardini, Carla (2016). Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: Relevance of nicotinic receptors. SCIENTIFIC REPORTS, vol. 6, pp. 1-15, ISSN:2045-2322 DOI

Pacini, A; Micheli, L; Maresca, M; Branca, Jj; Mcintosh, Jm; Ghelardini, C; Di Cesare Mannelli, L. (2016). The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment.. EXPERIMENTAL NEUROLOGY, vol. 282, pp. 37-48, ISSN:0014-4886 DOI

Costa, A.; Mannelli, L. D. C.; Ghelardini, C.; Blandina, P.; Passani, M. B.; Provensi, G. (2016). Lack of antidepressant-like effect of oleoylethanolamide in histamine-deficient mice parallels reduced hippocampal and cortical CREB phosphorylation. INFLAMMATION RESEARCH, vol. 65, pp. 21-21, ISSN:1023-3830

Sanna, M.D.; Galeotti, N.; Lucarini, L.; Lanzi, C.; Ghelardini, C.; Masini, E. (2016). Characterization of behavioral phenotypes in histamine H4-receptor knockout mice. INFLAMMATION RESEARCH, vol. 65, pp. 1-53, ISSN:1023-3830 DOI

Romanelli, M.N.; Bellucci, C.; Dei, S.; Ghelardini, C.; Manetti, D.; Teodori, E.; Gualtieri, F. (2016). The double life of UNIFI nootropics. In: XXIV National Meeting in Medicinal Chemistry, Perugia, 11-14 Settembre 2016, Società Chimica Italiana, pp. OC-8-OC-8.

Cappelli, Andrea; Anzini, Maurizio; Castriconi, Federica; Grisci, Giorgio; Paolino, Marco; Braile, Carlo; Valenti, Salvatore; Giuliani, Germano; Vomero, Salvatore; Di Capua, Angela; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Frosini, Maria; Ricci, Lorenzo; Giorgi, Gianluca; Mascia, Maria Paola; Biggio, Giovanni (2016). Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 3353-3372, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Grassi, Giacomo; Laura, Micheli; Lorenzo, Di Cesare Mannelli; Elisa, Compagno; Lorenzo, Righi; Carla, Ghelardini; Stefano, Pallanti (2016). Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation. JOURNAL OF PSYCHIATRIC RESEARCH, vol. 83, pp. 240-248, ISSN:0022-3956 DOI Accesso ONLINE all'editore

Maresca, Mario; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Innocenti, Marzia; Khatib, Mohamad; Mulinacci, Nadia; Ghelardini, Carla (2016). Acute effect of Capparis spinosa root extracts on rat articular pain. JOURNAL OF ETHNOPHARMACOLOGY, vol. 193, pp. 456-465, ISSN:0378-8741 DOI Accesso ONLINE all'editore

Del Bello, Fabio; Cilia, Antonio; Carrieri, Antonio; Fasano, Domenico Claudio; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Santini, Carlo; Diamanti, Eleonora; Giannella, Mario; Giorgioni, Gianfabio; Mammoli, Valerio; Paoletti, Corinne Dalila; Petrelli, Riccardo; Piergentili, Alessandro; Quaglia, Wilma; Pigini, Maria (2016). The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor. CHEMMEDCHEM, vol. 11, pp. 2287-2298, ISSN:1860-7179 DOI Accesso ONLINE all'editore

Bianchi, Enrica; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Farzad, Mersedez; Aglianò, Margherita; Ghelardini, Carla (2016). Apoptotic Process Induced by Oxaliplatin in Rat Hippocampus Causes Memory Impairment. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, pp. 1-8, ISSN:1742-7835 DOI Accesso ONLINE all'editore

Bird, Mark F.; Camilla Cerlesi, Maria; Brown, Mark; Malfacini, Davide; Vezzi, Vanessa; Molinari, Paola; Micheli, Laura; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Guerrini, Remo; Calò, Girolamo; Lambert, David G. (2016). Characterisation of the novel mixed Mu-NOP peptide ligand dermorphin-N/OFQ (DeNo). PLOS ONE, vol. 11 - e0156897, pp. 1-22, ISSN:1932-6203 DOI Accesso ONLINE all'editore

Roselli, Mariagrazia; Carocci, Alessia; Budriesi, Roberta; Micucci, Matteo; Toma, Maddalena; Di Cesare Mannelli, Lorenzo; Lovece, Angelo; Catalano, Alessia; Cavalluzzi, Maria Maddalena; Bruno, Claudio; De Palma, Annalisa; Contino, Marialessandra; Perrone, Maria Grazia; Colabufo, Nicola Antonio; Chiarini, Alberto; Franchini, Carlo; Ghelardini, Carla; Habtemariam, Solomon; Lentini, Giovanni (2016). Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 121, pp. 300-307, ISSN:0223-5234 DOI

Gonçalves, L.M.D.; Maestrelli, F; Di Cesare Mannelli, L.; Ghelardini, C.; Almeida, A.J.; Mura, P. (2016). Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 102, pp. 41-50, ISSN:0939-6411 DOI Accesso ONLINE all'editore

Brindisi, Margherita; Maramai, Samuele; Gemma, Sandra; Brogi, Simone; Grillo, Alessandro; Di Cesare Mannelli, Lorenzo; Gabellieri, Emanuele; Lamponi, Stefania; Saponara, Simona; Gorelli, Beatrice; Tedesco, Daniele; Bonfiglio, Tommaso; Landry, Christophe; Jung, Kwang-Mook; Armirotti, Andrea; Luongo, Livio; Ligresti, Alessia; Piscitelli, Fabiana; Bertucci, Carlo; Dehouck, Marie-Pierre; Campiani, Giuseppe; Maione, Sabatino; Ghelardini, Carla; Pittaluga, Anna; Piomelli, Daniele; Di Marzo, Vincenzo; Butini, Stefania (2016). Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 2612-2632, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella (2015). Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, pp. 1700-1704, ISSN:0960-894X DOI

Consalvi, Sara; Alfonso, Salvatore; Di Capua, Angela; Poce, Giovanna; Pirolli, Adele; Sabatino, Manuela; Ragno, Rino; Anzini, Maurizio; Sartini, Stefania; La Motta, Concettina; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Biava, Mariangela (2015). Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 810-820, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Claudia Vergelli; Giovanna Ciciani; Agostino Cilibrizzi; Letizia Crocetti; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Gabriella Guerrini; Antonella Iacovone; Maria Paola Giovannoni (2015). Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 6237-6245, ISSN:0968-0896

Martino, M. V.; DI CESARE MANNELLI, L. ; Bartolucci, G.; S, . DEI; Manetti, D.; Ghelardini, C.; Teodori, E.; Romanelli, M. N. (2015). 2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235. In: XXIII National Meeting on Medicinal Chemistry and 9th Young Medicinal Chemists Symposium (XXIII NMMC – 9th NPCF), Salerno, 6-9 settembre 2015, Edizioni Ziino, pp. 136-136.

Micheli, Laura; Di Cesare Mannelli, Lorenzo; Rizzi, Anna; Guerrini, Remo; Trapella, Claudio; Calò, Girolamo; Ghelardini, Carla (2015). Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 766, pp. 155-162, ISSN:0014-2999 DOI Accesso ONLINE all'editore

Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Zanardelli, Matteo; Failli, Paola; Ghelardini, Carla (2015). α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity. NEURAL PLASTICITY, vol. 2015, pp. 396908-396917, ISSN:2090-5904 DOI Accesso ONLINE all'editore

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Carta, Fabrizio; Cozzi, Andrea; Ghelardini, Carla; Supuran, Claudiu T (2015). Carbonic anhydrase inhibition for the management of cerebral ischemia: in vivo evaluation of sulfonamide and coumarin inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, pp. 1-6, ISSN:1475-6366 DOI

Di Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Bartolucci, Gianluca; Karioti, Anastasia; Bilia, Anna Rita; Vannacci, Alfredo; Mugelli, Alessandro; Ghelardini, Carla (2015). In Vitro Evidence for the Use of Astragali Radix Extracts as Adjuvant against Oxaliplatin-Induced Neurotoxicity. PLANTA MEDICA, vol. 81, pp. 1045-1055, ISSN:0032-0943 DOI Accesso ONLINE all'editore

Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Zanardelli, Matteo; Maidecchi, Anna; Lugli, Andrea; Mattoli, Luisa; Ghelardini, Carla (2015). Widespread pain reliever profile of a flower extract of Tanacetum parthenium. PHYTOMEDICINE, vol. 22, pp. 752-758, ISSN:0944-7113 DOI Accesso ONLINE all'editore

Mennini, Natascia; Mura, Paola; Nativi, Cristina; Richichi, Barbara; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2015). Injectable liposomal formulations of opiorphin as a new therapeutic strategy in pain management. FUTURE SCIENCE OA, vol. 1, pp. 1-10, ISSN:2056-5623 Accesso ONLINE all'editore

Di Cesare Mannelli, Lorenzo; Pacini, Alessandra; Corti, Francesca; Boccella, Serena; Luongo, Livio; Esposito, Emanuela; Cuzzocrea, Salvatore; Maione, Sabatino; Calignano, Antonio; Ghelardini, Carla (2015). Antineuropathic profile of N-palmitoylethanolamine in a rat model of oxaliplatin-induced neurotoxicity. PLOS ONE, vol. 10, pp. e0128080-e128104, ISSN:1932-6203 DOI

Gualdani, R.; Cerruti, S.; Magni, G.; Merli, D.; Di Cesare Mannelli, L.; Francesconi, O.; Richichi, B.; la Marca, G.; Ghelardini, C.; Moncelli, M.R.; Nativi, C. (2015). Lipoic-Based TRPA1/TRPV1 Antagonist to Treat Orofacial Pain. ACS CHEMICAL NEUROSCIENCE, vol. 6, pp. 380-385, ISSN:1948-7193 DOI

Nistri, S; Di Cesare Mannelli, L; Ghelardini, C; Zanardelli, M; Bani, D; Failli, P. (2015). Pretreatment with relaxin does not restore no-mediated modulation of calcium signal in coronary endothelial cells isolated from spontaneously hypertensive rats. MOLECULES, vol. 20, pp. 9524-9535, ISSN:1420-3049 DOI Accesso ONLINE all'editore

Carta, Fabrizio; Di Cesare Mannelli, Lorenzo; Pinard, Melissa; Ghelardini, Carla; Scozzafava, Andrea; Mckenna, Robert; Supuran, Claudiu T. (2015). A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, pp. 1828-1840, ISSN:0968-0896 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Ghelardini, Carla; Galeotti, Nicoletta (2015). Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia. PAIN, vol. 156, pp. 1265-75-1275, ISSN:0304-3959 DOI

Sanna, Maria Domenica; Stark, Holger; Lucarini, Laura; Ghelardini, Carla; Masini, Emanuela; Galeotti, Nicoletta (2015). Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK and P38 MAPK phosphorylation. PAIN, vol. 156, pp. 2492-2504, ISSN:0304-3959 DOI

Micheli, Laura; Di Cesare Mannelli, Lorenzo; Guerrini, Remo; Trapella, Claudio; Zanardelli, Matteo; Ciccocioppo, Roberto; Rizzi, Anna; Ghelardini, Carla; Calò, Girolamo (2015). Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 754, pp. 73-81, ISSN:0014-2999 DOI Accesso ONLINE all'editore

Zanardelli, Matteo; Micheli, Laura; Nicolai, Raffaella; Failli, Paola; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2015). Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, pp. 5386-5399, ISSN:1661-6596 DOI Accesso ONLINE all'editore

Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Bianchi, Enrica (2015). The pharmacological basis of opioids. CLINICAL CASES IN MINERAL AND BONE METABOLISM, vol. 12, pp. 219-221, ISSN:1724-8914 DOI

Di Cesare Mannelli, Lorenzo; Corti, Francesca; Micheli, Laura; Zanardelli, Matteo; Ghelardini, Carla (2015). Delay of morphine tolerance by palmitoylethanolamide. BIOMED RESEARCH INTERNATIONAL, vol. 2015, pp. 1-12, ISSN:2314-6133 DOI Accesso ONLINE all'editore

Ghelardini, C; Di Cesare Mannelli, L.; Cerretani, D.; Bianchi, E. (2015). GLUTAMATERGIC SYSTEM MODULATORS AS AGENTS IN PREVENTION AND MANAGEMENT OF CHEMOTHERAPY- INDUCED POLYNEUROPATHY. THERAPEUTIC TARGETS FOR NEUROLOGICAL DISEASES, vol. 2:e672, pp. 1-3, ISSN:2376-0478 DOI

Nistri, Silvia; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Zanardelli, Matteo; Bani, Daniele; Failli, Paola (2015). Pretreatment with Relaxin Does Not Restore NO-Mediated Modulation of Calcium Signal in Coronary Endothelial Cells Isolated from Spontaneously Hypertensive Rats. MOLECULES, vol. 20, pp. 9524-9535, ISSN:1420-3049 DOI

Di Cesare Mannelli, Lorenzo; Marcoli, Manuela; Micheli, Laura; Zanardelli, Matteo; Maura, Guido; Ghelardini, Carla; Cervetto, Chiara (2015). Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1. NEUROPHARMACOLOGY, vol. 97, pp. 133-41-141, ISSN:0028-3908 DOI

Gualdani, Roberta; Ceruti, Stefania; Magni, Giulia; Merli, Davide; di Cesare Mannelli, Lorenzo; Francesconi, Oscar; Richichi, Barbara; la Marca, Giancarlo; Ghelardini, Carla; Moncelli, Maria Rosa; Nativi, Cristina (2015). The Role of TRPA1 and TRPV1 Channels in Orofacial Pain. BIOPHYSICAL JOURNAL, vol. 108, pp. 123a-123a, ISSN:0006-3495 DOI

Di Cesare Mannelli, Lorenzo; Maresca, Mario; Farina, Carlo; Scherz, Michael W; Ghelardini, Carla (2015). A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. NEUROTOXICOLOGY, vol. 50, pp. 101-7-107, ISSN:0161-813X DOI Accesso ONLINE all'editore

Sanna MD; Peroni D; Quattrone A; Ghelardini C; Galeotti N (2015). Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.. EXPERIMENTAL NEUROLOGY, vol. 267, pp. 53-63, ISSN:0014-4886 DOI

M. D. Sanna;C. Ghelardini;N. Galeotti (2015). Differential contribution of Gαi/o subunits in the response to food deprivation.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 750, pp. 27-31, ISSN:0014-2999 DOI Accesso ONLINE all'editore

Sanna, Maria Domenica; Mello, Tommaso; Ghelardini, Carla; Galeotti, Nicoletta (2015). Inhibition of spinal ERK1/2-c-JUN signaling pathway counteracts the development of low doses morphine-induced hyperalgesia. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 764, pp. 271-277-277, ISSN:0014-2999 DOI

M. P. Giovannoni;G. Ciciani;A. Cilibrizzi;L. Crocetti;S. Daniele;L. Di Cesare Mannelli;C. Ghelardini;C. Giacomelli;G. Guerrini;C. Martini;M. L. Trincavelli;C. Vergelli (2015). Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 89, pp. 32-41, ISSN:0223-5234 DOI Accesso ONLINE all'editore

Squarcialupi, L.; Falsini, M.; Catarzi, D.; Varano, F.; Betti, M.; Di Cesare Mannelli, L.; Zanardelli, M.; Ghelardini, C.; Tanc, M.; Supuran, C.T.; Colotta, V. (2015). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 131-131.

Cinci, Lorenzo; Corti, Francesca; Di Cesare Mannelli, Lorenzo; Micheli, Laura; Zanardelli, Matteo; Ghelardini, Carla (2015). Oxidative, Metabolic, And Apoptotic Responses of Schwann Cells to High Glucose Levels. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol. 29, pp. 274-279, ISSN:1095-6670 DOI Accesso ONLINE all'editore

Ghelardini, Carla; Di Cesare Mannelli, Lorenzo (2015). Composizioni atte a favorire il miglioramento delle prestazioni intellettuali. Numero: MI2015A000549 Ghelardini Carla, Di Cesare Mannelli Lorenzo

Betti, Marco; Catarzi, Daniela; Varano, Flavia; Varani, Katia; Lorenzo Di Cesare Mannelli, ; Zanardelli, M.; Ghelardini, Carla; Colotta, Vittoria . (2015). Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists.. In: XXIII National Meeting on Medicinal Chemistry, 6-9 settembre 2015, Salerno., d, pp. 132-132.

Di Cesare Mannelli, Lorenzo; Micheli, Laura; Ghelardini, Carla (2015). Nociceptin/orphanin FQ receptor and pain: Feasibility of the fourth opioid family member. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 766, pp. 151-4-154, ISSN:0014-2999 DOI

Grandane, Aiga; Tanc, Muhammet; Di Cesare Mannelli, Lorenzo; Carta, Fabrizio; Ghelardini, Carla; Žalubovskis, Raivis; Supuran, Claudiu T. (2015). 6-substituted sulfocoumarins are selective carbonic anhdydrase IX and XII Inhibitors with significant cytotoxicity against colorectal cancer cells. JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, pp. 3975-3983, ISSN:0022-2623 DOI Accesso ONLINE all'editore

Pallanti, Stefano; Tofani, Tommaso; Zanardelli, Matteo; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2014). BDNF and ARTEMIN are increased in drug-naïve non-depressed GAD patients: Preliminary data. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, vol. 18, pp. 255-260, ISSN:1365-1501 DOI Accesso ONLINE all'editore

L. Cinci;L. Di Cesare Mannelli;M. Zanardelli;L. Micheli;D. Guasti;C. Ghelardini (2014). Peroxisome determination in optical microscopy: a useful tool derived by a simplification of an old ultrastructural technique.. ACTA HISTOCHEMICA, vol. 116, pp. 863-870, ISSN:0065-1281 DOI Accesso ONLINE all'editore

M.D. Sanna;A. Quattrone;C. Ghelardini;N. Galeotti (2014). PKC-mediated HuD–GAP43 pathway activation in a mouse model of antiretroviral painful neuropathy. PHARMACOLOGICAL RESEARCH, vol. 81, pp. 44-53, ISSN:1043-6618 DOI

Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2014). Using palmitoylethanolamide in combination with opioids. Numero: Italia: MI2014A000876; USA: US 2015/0328173 A1 F. DELLA VALLE, M.F. DELLA VALLE, L. DI CESARE MANNELLI, C. GHELARDINI. EPITECH

Di Cesare Mannelli L.; Pacini A.; Micheli L.; Tani A.; Zanardelli M.; Ghelardini C. (2014). Glia role in oxaliplatin-induced neuropathic pain.. EXPERIMENTAL NEUROLOGY, vol. 261C, pp. 22-33, ISSN:0014-4886 DOI

Di Cesare Mannelli L; Cinci L; Micheli L; Zanardelli M; Pacini A; McIntosh JM; Ghelardini C (2014). alpha-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement.. PAIN, vol. 155, pp. 1986-1995, ISSN:0304-3959 DOI

Di Cesare Mannelli L.; Pacini A.; De Amici M.; Matera C:; Zanardelli M.; Mello T.; Dallanoce C.; Ghelardini C. (2014). Involvement of alpha7 nAChR subtype in rat oxaliplatin-induced neuropathy: effects of selective activation.. NEUROPHARMACOLOGY, vol. 79, pp. 37-48, ISSN:0028-3908 DOI

Nicoletta Galeotti;Anna Maidecchi;Luisa Mattoli;Michela Burico;Carla Ghelardini (2014). St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes. FITOTERAPIA, vol. 92, pp. 23-33, ISSN:1971-551X DOI

M.D. Sanna;A. Quattrone;T. Mello;C. Ghelardini;N. Galeotti (2014). The RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy. EXPERIMENTAL NEUROLOGY, vol. 261, pp. 343-353, ISSN:0014-4886 DOI

Natascia Mennini; Sandra Furlanetto; Marco Bragagni; Carla Ghelardini; Lorenzo Di Cesare Mannelli; Paola Mura (2014). Development of a chitosan-derivative micellar formulation to improve celecoxib asolubility and bioavailability. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 40, pp. 1494-1502, ISSN:0363-9045 DOI Accesso ONLINE all'editore

Baptista-De Souza D; Di Cesare Mannelli L; Zanardelli M; Micheli L; Nunes-De Souza RL; Canto-De Souza A; Ghelardini C (2014). Serotonergic modulation in neuropathy induced by oxaliplatin: Effect on the 5HT2C receptor. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 735, pp. 141-149, ISSN:0014-2999 DOI

Nicoletta Galeotti;Mersedeh Farzad;Enrica Bianchi;Carla Ghelardini (2014). PKC-Mediated Potentiation of Morphine Analgesia by St. John’s Wort in Rodents and Humans. JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 124, pp. 409-417, ISSN:1347-8613 DOI

Bianchi E; Di Cesare Mannelli L; Menicacci C; Lorenzoni P; Aglianò M; Ghelardini C (2014). Prophylactic role of acetyl-L-carnitine on knee lesions and associated pain in a rat model of osteoarthritis. LIFE SCIENCES, vol. 106, pp. 32-39, ISSN:0024-3205 DOI

Ghelardini C; Menicacci C; Cerretani D; Bianchi E (2014). Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat. NEUROPHARMACOLOGY, vol. 86, pp. 294-300, ISSN:0028-3908 DOI

Pacini A; Micheli L; Di Cesare Mannelli L; Mugelli A; Ghelardini C (2014). Astragalus membranaceus and oxaliplatin-induced neuropathy: pain relief and prevention of nervous tissue modifications.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 119, pp. 147-147, ISSN:1122-6714

M.D. Sanna; N. Galeotti; L. Lucarini; C. Lanzi; H. Stark; C. Ghelardini; E. Masini (2014). HISTAMINE H4 RECEPTOR ACTIVATION INDUCES ANTINOCICEPTION IN A NEUROPATHIC PAIN MODEL. INFLAMMATION RESEARCH, vol. 63 (Suppl 1), pp. S16-S17, ISSN:1023-3830 DOI

Nativi, Cristina; Ghelardini, Carla; LA MARCA, Giancarlo (2014). NOVEL COMPOUNDS HAVING ANTI-ALLODYNIC AND ANTIHYPERALGESIC ACTIVITY. Numero: PCT WO/2015/128697 CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI [IT/IT]; Piazza S.Marco, 4 I-50121 Firenze (IT). UNIVERSITA' DEGLI STUDI DI FIRENZE [IT/IT]; Piazza San Marco, 4 I-50121 Firenze (IT)

Maria Domenica Sanna;Carla Ghelardini;Nicoletta Galeotti (2014). Regionally selective activation of ERK and JNK in morphine paradoxical hyperalgesia: A step toward improving opioid pain therapy. NEUROPHARMACOLOGY, vol. 86, pp. 67-77, ISSN:0028-3908 DOI

Fariello RG; Ghelardini C; Di Cesare Mannelli L; Bonanno G; Pittaluga A; Milanese M; Misiano P; FArina C (2014). Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain. NEUROPHARMACOLOGY, vol. 81, pp. 85-94, ISSN:0028-3908 DOI

Bellumori Maria; Marzia Innocenti; Giancarlo Cravotto; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Nadia Mulinacci (2014). Protective action of Rosemary extracts obtained by green innovative techniques on neuropathic pain. In: X Congresso Nazioanle di Chimica degli Alimenti, Firenze, 6-10 Luglio 2014, Nadia Mulinacci,Marzia Innocenti, vol. 1, pp. 35-35, ISBN:9788894004304

Elvira Fantechi;Claudia Innocenti;Matteo Zanardelli;Maria Fittipaldi;Elisabetta Falvo;Miriam Carbo;Valbona Shullani;Lorenzo Di Cesare Mannelli;Carla Ghelardini;Anna Maria Ferretti;Alessandro Ponti;Claudio Sangregorio;Pierpaolo Ceci (2014). A Smart Platform for Hyperthermia Application in Cancer Treatment: Cobalt-Doped Ferrite Nanoparticles Mineralized in Human Ferritin Cages. ACS NANO, vol. 8, pp. 4705-4719, ISSN:1936-0851 DOI

Zanardelli, M; Micheli, L; Cinci, L; Failli, P; Ghelardini, C; Di Cesare Mannelli, L (2014). Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARc Agonism as Preventive Pharmacological Approach. PLOS ONE, vol. 9, pp. 0-0, ISSN:1932-6203 DOI

Di Cesare Mannelli, L; Zanardelli, M; Micheli, L; Ghelardini, C (2014). PPAR-γ Impairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures. BIOMED RESEARCH INTERNATIONAL, pp. 0-0, ISSN:2314-6141 DOI

Marco Bragagni; Natascia Mennini; Sandra Furlanetto; Serena Orlandini; Carla Ghelardini; Paola Mura (2014). Development and characterization of functionalized niosomes for brain targeting of dynorphin-B. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 87, pp. 73-79, ISSN:0939-6411 DOI

GALEOTTI N; GHELARDINI C (2014). Hypericum perforatum L. as adjuvant of opioid analgesia in an animal model of migraine. BRITISH JOURNAL OF MEDICINE AND MEDICAL RESEARCH, vol. 4, pp. 1591-1603, ISSN:2231-0614

Biava M; Battilocchio C; Poce G; Alfonso S; Consalvi S; Di Capua A; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Ghelardini C; Di Cesare Mannelli L; Giordani A; Persiani S; Colovic M; Dovizio M; Patrignani P; Anzini M (2014). Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, pp. 772-786, ISSN:0968-0896 DOI

N. Galeotti;C. Ghelardini (2013). St. John's wort reversal of meningeal nociception: A natural therapeutic perspective for migraine pain. PHYTOMEDICINE, vol. 20, pp. 930-938, ISSN:0944-7113 DOI

L. Squarcialupi; V. Colotta; D. Catarzi; F. Varano; K. Varani; C. Corciulo; F. Vincenzi; A. Ciancetta; L. Di Cesare Mannelli; C. Ghelardini; S. Moro (2013). Arilpirazolo[4,3-d]pirimidin-7-ammino derivati quali nuovi antagonisti potenti e selettivi del recettore umano A3 dell’adenosina. In: TUMA 2013, Sesto Fiorentino (FI), 1-2-Luglio 2013, d, pp. 60-60.

Nicoletta Galeotti;Maria Domenica Sanna;Carla Ghelardini (2013). Pleiotropic effect of histamine H4 receptor modulation in the central nervous system. NEUROPHARMACOLOGY, vol. 71, pp. 141-147, ISSN:0028-3908 DOI

Di Cesare Mannelli L.; Pacini A.; Bonaccini L.; Zanardelli M.; Mello T.; Ghelardini C. (2013). Morphological features and glial activation in oxaliplatin-dependent neuropathic pain.. THE JOURNAL OF PAIN, vol. 14, pp. 1585-1600, ISSN:1526-5900 DOI

Tomassoni D.; Amenta F.; Di cesare Mannelli L.; Ghelardini C.; Nwankwo IE.; Pacini A.; Tayebaty SK. (2013). Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.. BIOMED RESEARCH INTERNATIONAL, vol. 2013 Article ID985093, pp. 1-14, ISSN:2314-6133 DOI Accesso ONLINE all'editore

Di Cesare Mannelli L.; D'Agostino G.; Pacini A.; Russo R.; Zanardelli M.; Ghelardini C.; Calignano A. (2013). Palmitoylthanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-apha-mediated mechanism.. MEDIATORS OF INFLAMMATION, vol. Article ID 328797, pp. 1-12, ISSN:1466-1861 DOI

L. Di Cesare Mannelli; D. Bani; A. Bencini; M.L. Brandi; L. Calosi; M. Cantore; A.M. Carossino; C. Ghelardini; B. Valtancoli; P. Failli (2013). Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn(II)Me2DO2A on Experimental Articular Pain in Rats.. MEDIATORS OF INFLAMMATION, vol. 2013, pp. 1-12, ISSN:0962-9351 DOI Accesso ONLINE all'editore

Bianchi E; Menicacci C; Ghelardini C (2013). Dual effect of morphine in long-term social memory in rat. BRITISH JOURNAL OF PHARMACOLOGY, vol. 168, pp. 1768-1793, ISSN:0007-1188 DOI

Di Cesare Mannelli L; Micheli L; Zanardelli M; Ghelardini C (2013). Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC MUSCULOSKELETAL DISORDERS, vol. 14, pp. 228-235, ISSN:1471-2474 DOI

Carrino D; Tani A; Di Cesare Mannelli L; Sgambati E; Ghelardini C; Pacini A (2013). Glia inhibition suppress chemotherapy-induced neuropathic pain in the rat.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 118, pp. 48-48, ISSN:1122-6714

Gabriella Guerrini; Giovanna Ciciani; Annarella Costanzo; Simona Daniele; Caludia Martini; Carla Ghelardini; Lorenzo Di Cesare Mannelli. (2013). Synthesis of novel cognition enhancer with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at gamma-aminobutyric acid type A (GABAA) receptor.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 2186-2198, ISSN:1464-3391 DOI

Martelli A; Testai L; Anzini M; Cappelli A; Di Capua A; Biava M; Poce G; Consalvi S; Giordani A; Caselli G; Rovati L; Ghelardini C; Patrignani P; Sautebin L; Breschi MC; Calderone V (2013). The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.. PHARMACOLOGICAL RESEARCH, vol. 78, pp. 1-9, ISSN:1043-6618 DOI

Anzini M; Di Capua A; Valenti S; Brogi S; Rovini M; Giuliani G; Cappelli A; Vomero S; Chiasserini L; Sega A; Poce G; Giorgi G; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Pace G; Ghelardini C; Di Cesare Mannelli L; Benetti V; Giordani A; Anzellotti P; Dovizio M; Patrignani P; Biava M (2013). Novel Analgesic/Anti-Inflammatory Agents: 1,5-Diarylpyrrole Nitrooxyalkyl Ethers and Related Compounds as Cyclooxygenase‐2 Inhibiting Nitric Oxide Donors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 3191-3206, ISSN:1520-4804 DOI

Di Cesare Mannelli L; Zanardelli M; Failli P; Ghelardini C (2013). Oxaliplatin-induced oxidative stress in nervous system-derived cellular models: Could it correlate with in vivo neuropathy?. FREE RADICAL BIOLOGY & MEDICINE, vol. 61, pp. 143-150, ISSN:0891-5849 DOI

Di Cesare Mannelli L; Zanardelli M; Ghelardini C (2013). Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 711, pp. 87-94, ISSN:0014-2999 DOI

Fiore G; Ghelardini C; Bruni G; Guarna M; Bianchi E (2013). Differentiation state affects morphine induced cell regulation in neuroblastoma cultured cells.. NEUROSCIENCE LETTERS, vol. 555, pp. 51-56, ISSN:0304-3940 DOI

Lucia Squarcialupi;Vittoria Colotta;Daniela Catarzi;Flavia Varano;Guido Filacchioni;Katia Varani;Carmen Corciulo;Fabrizio Vincenzi;Pier Andrea Borea;Carla Ghelardini;Lorenzo Di Cesare Mannelli;Antonella Ciancetta;Stefano Moro (2013). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, pp. 2256-2269, ISSN:0022-2623 DOI

Battilocchio C; Poce G; Alfonso S; Porretta GC; Consalvi S; Sautebin L; Pace S; Rossi A; Ghelardini C; Di Cesare Mannelli L; Schenone S; Giordani A; Di Francesco L; Patrignani P; Biava M (2013). A class of pyrrole derivatives endowed with analgesic/anti- inflammatory activity. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, pp. 3695-3701, ISSN:0968-0896 DOI

Galeotti N;Ghelardini C (2013). Inhibition of the PKCγ-ε Pathway Relieves from Meningeal Nociception in an Animal Model: An Innovative Perspective for Migraine Therapy?. NEUROTHERAPEUTICS, vol. 10, pp. 329-339, ISSN:1933-7213 DOI

N Galeotti; C Ghelardini (2013). St. John's wort relieves pain in an animal model of migraine.. EUROPEAN JOURNAL OF PAIN, vol. 17, pp. 369-381, ISSN:1090-3801 DOI

Nativi, Cristina; Gualdani, R; Dragoni, Elisa; DI CESARE MANNELLI, Lorenzo; Sostegni, S; Norcini, M; Gabrielli, G; LA MARCA, Giancarlo; Richichi, Barbara; Francesconi, Oscar; Moncelli, MARIA ROSA; Ghelardini, Carla; Roelens, Stefano (2013). A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. SCIENTIFIC REPORTS, vol. 3, pp. 1-10, ISSN:2045-2322 DOI

Nicoletta Galeotti;Carla Ghelardini (2013). PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior. ISRN PAIN, vol. 2013, pp. 1-10, ISSN:2314-4718 DOI

Battilocchio C; Guetzoyan L; Cervetto C; Di Cesare Mannelli L; Frattaroli D; Baxendale IR; Maura G; Rossi A; Sautebin L; Biava M; Ghelardini C; Marcoli M; Ley SV (2013). Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7‐Evoked Glutamate Release. ACS MEDICINAL CHEMISTRY LETTERS, vol. 4, pp. 704-709, ISSN:1948-5875 DOI

Nicoletta Galeotti;Carla Ghelardini (2013). Reversal of NO-induced nociceptive hypersensitivity by St. John’s wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. PSYCHOPHARMACOLOGY, vol. 227, pp. 149-163, ISSN:0033-3158 DOI

Luca Guandalini; Maria Vittoria Martino; Lorenzo Di Cesare Mannelli; Cristina Bellucci; Silvia Dei; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carla Ghelardini; Maria Novella Romanelli (2012). New analogues of the potent nootropic drug DM235: 2-or 3-phenylpiperazines with limited conformational flexibility. In: 21 th National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 74-74.

N. Galeotti;C. Ghelardini (2012). Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline.. NEUROPHARMACOLOGY, vol. 62, pp. 289-296, ISSN:0028-3908 DOI Accesso ONLINE all'editore

M. Bragagni; N. Mennini; C. Ghelardini; P. Mura (2012). Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting. JOURNAL OF PHARMACY & PHARMACEUTICAL SCIENCES, vol. 15, pp. 184-196, ISSN:1482-1826 Accesso ONLINE all'editore

N. Galeotti;C. Ghelardini (2012). Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation.. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, vol. 15, pp. 781-793, ISSN:1461-1457 DOI Accesso ONLINE all'editore

Catalano A; Desaphy J; Lentini G; Carocci A; Di Mola A; Bruno C; Carbonara R; De Palma A; Budriesi R; Ghelardini C; Perrone MG; Colafubo NA; Conte-Camerino D; Franchini C (2012). Synthesis and Toxicopharmacological Evaluation of m-Hydroxymexiletine, the First Metabolite of Mexiletine More Potent Than the Parent Compound on Voltage-Gated Sodium Channels. JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, pp. 1418-1422, ISSN:1520-4804 DOI

V. Colotta; L. Squarcialupi; D. Catarzi; F. Varano; K. Varani; F. Vincenzi; M. Zanardelli; L. Di Cesare Mannelli; C. Ghelardini; S. Paoletta; S. Moro (2012). 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures. In: 21st National Meeting on Medicinal Chemistry, Palermo, 17-20 Luglio 2012, d, pp. 0-0.

Colotta V;Lenzi O;Catarzi D;Varano F;Squarcialupi L;Costagli C;Galli A;Ghelardini C;Pugliese AM;Maraula G;Coppi E;Pellegrini-Giampietro DE;Pedata F;Sabbadin D;Moro S (2012). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 470-482, ISSN:0223-5234 DOI

L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli (2012). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, pp. 1936-1939, ISSN:0960-894X DOI Accesso ONLINE all'editore

Biava M; Battilocchio C; Poce G; Alfonso S; Porretta GC; Schenone S; Calderone V; Martelli A; Testai L; Ghelardini C; Di Cesare Mannelli L; Sautebin L; Rossi A; Giordani A; Patrignani P; Anzini M; Consalvi S (2012). Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, pp. 287-298, ISSN:0223-5234 DOI

L. Di Cesare Mannelli; M. Zanardelli; P. Failli; C. Ghelardini (2012). Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. THE JOURNAL OF PAIN, vol. 13, pp. 276-284, ISSN:1526-5900 Accesso ONLINE all'editore

L. Di Cesare Mannelli; L. Bonaccini; M. Zanardelli; T. Mello; A. Pacini; C. Ghelardini (2012). Involvement of alpha7 nAChR downregulation in rat oxaliplatin-induced neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 117, pp. 57-57, ISSN:1122-6714

C. Nativi; O. Francesconi; G. Gabrielli; I. De Simone; B. Turchetti; T. Mello; L. Di Cesare Mannelli; C. Ghelardini; P. Buzzini; S. Roelens (2012). Aminopyrrolic synthetic receptors for monosaccharides: A class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. CHEMISTRY, vol. 18, pp. 5064-5072, ISSN:1521-3765 DOI Accesso ONLINE all'editore

V Mercati; F F Vincieri; A R Bilia; C Ghelardini; N Galeotti (2011). Use of hypericum perforatum extracts in the treatment of neuropathic pain. Numero: EP Patent 2,247,296, 2010; US8906430 US Patent Number, December 9, 2014 Aboca SpA Società Agricola

C. Ghelardini; L. Di Cesare Mannelli; M. Zanardelli; L. Bonaccini; A. Pacini (2011). Neuropathic pain: looking for a disease modifyng agent. In: XXI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), San Benedetto del Tronto, 9-10 Giugno, pp. 0-0.

M. Biava;G. C. Porretta;G. Poce;C. Battilocchio;M. Botta;F. Manetti;M. Rovini;A. Cappelli;L. Sautebin;A. Rossi;C. Pergola;C. Ghelardini;N. Galeotti;F. Makovec;A. Giordani;P. Anzellotti;S. Tacconelli;P. Patrignani;M. Anzini (2011). Enlarging the NSAIDs family: ether, ester and acid derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.. CURRENT MEDICINAL CHEMISTRY, vol. 18, pp. 1540-1554, ISSN:0929-8673 DOI

E. Bianchi;N. Galeotti;C. Menicacci;C. Ghelardini (2011). Contribution of G inhibitory protein alpha subunits in paradoxical hyperalgesia elicited by exceedingly low doses of morphine in mice.. LIFE SCIENCES, vol. 89, pp. 918-925, ISSN:0024-3205 DOI Accesso ONLINE all'editore

N. Galeotti;C. Ghelardini (2011). Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test.. NEUROPHARMACOLOGY, vol. 60, pp. 937-943, ISSN:0028-3908 DOI Accesso ONLINE all'editore

Lorenzo Di Cesare Mannelli;Elisa Vivoli;Alberto Salvicchi;Nicola Schiavone;Aleardo Koverech;Masa Messano;Raffaella Nicolai;Paola Benatti;Alessandro Bartolini;Carla Ghelardini (2011). Antidepressant-like effect of artemin in mice: a mechanism for acetyl-l-carnitine activity on depression. PSYCHOPHARMACOLOGY, vol. 218, pp. 347-356, ISSN:0033-3158 DOI

B Isacchi; V. Fabbri; N Galeotti; MC Bergonzi; A Karioti; C Ghelardini; MG Vannucchi; AR Bilia (2011). Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 44, pp. 552-558, ISSN:0928-0987 DOI

L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Glia activation along the nervous system during oxaliplatin-dependent neuropathic pain.. In: 8th IBRO World Congress of Neuroscience, Firenze, 14-18 Luglio, pp. 0-0.

E.I. Nwankwo; F. Amenta; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; S.K. Tayebati; D. Tomassoni (2011). Central nervous system changes in a model of compressive neuropathy: thioctic acid enantiomers activity.. In: XXI Convegno Nazionale del Gruppo perlo Studio della Neuromorfologia (GISN), San benedetto del Tronto, 9-10 Giugno, pp. 0-0.

L. Guandalini; E. Martini; L. Di Cesare Mannelli; S. Dei; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M. Novella Romanelli (2011). Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 Settembre 2011, società chimica italiana, pp. 442-442.

E.I. Nwankow; F. Amenta; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; S.K. Tayebati; D. Tomassoni (2011). Thioctic acid enantiomers prevent central nervous system changes occurring in a model of compressive neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, pp. 94-94, ISSN:1122-6714

Biava M; Porretta GC; Poce G; Battilocchio C; Alfonso S; Rovini M; Valenti S; Giorgi G; Calderone V; Martelli A; Testai L; Sautebin L; Rossi A; Papa G; Ghelardini C; Di Cesare Mannelli L; Giordani A; Anzellotti P; Bruno A; Patrignani P; Anzini M (2011). Novel Analgesic/Anti-Inflammatory Agents: Diarylpyrrole Acetic Esters Endowed with Nitric Oxide Releasing Properties. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 7759-7771, ISSN:1520-4804 DOI

L. Di Cesare Mannelli; L. Bonaccini; T. Mello; M. Zanardelli; A. Pacini; C. Ghelardini (2011). Oxaliplain-induced neruopathic pain: glial involvement in spinal cord and brain.. In: 34° Congresso Associazione Italiana per lo Studio del Dolore, Riccione, 29-31 Maggio, pp. 0-0.

L. Di Cesare Mannelli; M. Zanardelli; A. pacini; C. Ghelardini (2011). Involvement of alpha7 nAChR downregulation in the rat oxaliplatin-induced neuropathy.. In: 35° Congresso Società Italiana di Farmacologia (SIF), Bologna, 14-17 Settembre, pp. 0-0.

Anzini M; Valenti S; Braile C; Cappelli A; Vomero S; Alcaro S; Ortuso F; Marinelli L; Limongelli V; Novellino E; Betti L; Giannaccini G; Lucacchini A; Daniele S; Martini C; Ghelardini C; Di Cesare Mannelli L; Giorgi G; Mascia MP; Biggio G (2011). New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 5694-5711, ISSN:1520-4804 DOI

Cappelli A; Bini G; Valenti S; Giuliani G; Paolino M; Anzini M; Vomero S; Giorgi G; Giordani A; Stasi LP; Makovec F; Ghelardini C; Di Cesare Mannelli L; Concas A; Porcu P; Biggio G (2011). Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 7165-7175, ISSN:1520-4804 DOI

V. Colotta; D. Catarzi; F. Varano; C. Costagli; C. Ghelardini; A.M. Pugliese; G. Maraula; D. Sabbadin; S. Moro (2011). 3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. In: XXIV Congresso Nazionale della Società Chimica Italiana, Lecce, 11-16 settembre 2011, d, pp. 388-388.

L. Di Cesare Mannelli; C. dallanoce; C. Matera; M. Zanardelli; A. Pacini; C. De Micheli; M. De Amici; C. Ghelardini (2011). Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype.. In: New insights in the pharmacological control of pain, Milano, 30 settembre, pp. 0-0.

Bartolini, Alessandro; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla (2011). Analgesic and antineuropathic drugs acting through central cholinergic mechanisms. RECENT PATENTS ON CNS DRUG DISCOVERY, vol. 6, pp. 119-140, ISSN:2212-3954 DOI

Isacchi B; Iacopi R; Bergonzi MC; Ghelardini C; Galeotti N; Norcini M; Vivoli E; Vincieri FF; Bilia AR (2011). Antihyperalgesic activity of verbascoside in two models of neuropathic pain.. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 63, pp. 594-601, ISSN:0022-3573 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Martini; S. Daniele; C. Ghelardini; L. Di Cesare Mannelli; A. Costanzo (2011). Development of ligands at gamma aminobutyrric acid type A (GABAA) receptor subtype as new agent for pain relief.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, pp. 7441-7452, ISSN:1464-3391 DOI

E. Martini; L. Di Cesare Mannelli; G. Bartolucci; C. Bertucci; S. Dei; C. Ghelardini; L. Guandalini; D. Manetti; S. Scapecchi; E. Teodori; M. N. Romanelli (2011). Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, pp. 2512-2516, ISSN:0022-2623 DOI Accesso ONLINE all'editore

L. Bonaccini; L. Di Cesare Mannelli; M. Zanardelli; E. Sgambati; C. Ghelardini; A. Pacini (2011). An in vivo sudy on oxaliplatin-induced neuropathic pain: the protective effects of antioxidant compounds. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 116, pp. 26-26, ISSN:1122-6714

A.R. Bilia; L. Di Cesare Mannelli; F. Firenzuoli; E. Gallo; C. Ghelardini; A. Karioti; A. Mugelli; A. Pacini; A. Vannacci; M. Zanardelli (2011). Estratti di Astragalus membranaceus loro preparazione ed uso come antiperalgesici ed antiallodinici. Numero: 1145PTIT A. MUGELLI

Carocci A; Lentini G; Catalano A; Cavalluzzi MM; Bruno C; Muraglia M; Colabufo NA; Galeotti N; Corbo F; Matucci R; Ghelardini C; Franchini C. (2010). Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity. CHEMMEDCHEM, vol. 5, pp. 696-704, ISSN:1860-7179 DOI

Vivoli E; Di Cesare Mannelli L; Salvicchi A; Bartolini A; Koverech A; nicolai R; Benatti P; Ghelardini C (2010). Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy. NEUROSCIENCE, vol. 167, pp. 1168-1174, ISSN:0306-4522 DOI

F.Maestrelli; M.L.Gonzales Rodriguez; A.M.Rabasco; C.Ghelardini; P.Mura (2010). New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 395, pp. 222-231, ISSN:0378-5173 DOI

C. Nativi; C. Ghelardini; E. Dragoni (2010). Composti ad efficacia sia analgesica che antiperalgesica. Numero: 10049PTIT C. Nativi, C. Ghelardini, E. Dragoni

Pitozzi, Vanessa; Jacomelli, M.; Zaid, M.; Luceri, Cristina; Bigagli, Elisabetta; Lodovici, Maura; Ghelardini, Carla; Vivoli, E.; Norcini, M.; Gianfriddo, M.; Esposto, S.; Servili, M.; Morozzi, G.; Baldi, Elisabetta; Bucherelli, Corrado; Dolara, Piero; Giovannelli, Lisa (2010). Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in aging rats. BRITISH JOURNAL OF NUTRITION, vol. 103, pp. 1674-1683, ISSN:1475-2662

N.Galeotti; E. Vivoli; A.R. Bilia; M.C. Bergonzi; A. Bartolini; C. Ghelardini (2010). A Prolonged Protein Kinase C-Mediated, Opioid-Related Antinociceptive Effect of St John's Wort in Mice. THE JOURNAL OF PAIN, vol. 11, pp. 149-159, ISSN:1526-5900 DOI

M. Biava;G. C. Porretta;G. Poce;C. Battilocchio;F. Manetti;M. Botta;S. Forli;L. Sautebin;A. Rossi;C. Pergola;C. Ghelardini;N. Galeotti;F. Makovec;A. Giordani;P. Anzellotti;P. Patrignani;M. Anzini (2010). Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 723-733, ISSN:1520-4804 DOI Accesso ONLINE all'editore

NATIVI C.; GHELARDINI C.; LA MARCA G.; DRAGONI E. (2010). COMPOUNDS WITH BOTH ANALGESIC AND ANTI-HYPERALGESIC EFFICACY. Numero: WO 2011080725 A1 NATIVI, Cristina [IT/IT]; (IT).GHELARDINI, Carla [IT/IT]; (IT).LA MARCA, Giancarlo [IT/IT]; (IT).DRAGONI, Elisa [IT/IT]; (IT).CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI (INSTM) [IT/IT]; Piazza San Marco, 4 I-50121 Firenze (IT) (For All Designated States Except US)

Nicoletta Galeotti;Elisa Vivoli;Anna Rita Bilia;Franco Francesco Vincieri;Carla Ghelardini (2010). St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase C γ and ɛ activity. BIOCHEMICAL PHARMACOLOGY, vol. 79, pp. 1327-1336, ISSN:0006-2952 DOI

D. Tomassoni; L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; D. Alagna; C. Ghelardini; F. Amenta (2010). Valutazione comparativa dell'efficacia dell'acido tioctico enantiomero (+) e racemo (+/-) in modelli di aumentato stress ossidativo.. In: R (+) dalla ricerca di base alle applicazioni cliniche dell'enantiomero naturale di un antiossidante multifunzionale, Roma, 14 Settembre, pp. 0-0.

L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; C. Ghelardini; A. Bartolini (2010). Oxaliplatin-dependent neuropathy in the rat: pain behaviour and peripheral nervous system alterations.. In: 16th World Congress of Basic and Clinical Pharmacology, Copenhagen - Danimarca, 17-23 Luglio, pp. 0-0.

L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; C. Ghelardini (2010). Alteration in neuron and glia gene expression profile as actors involved in the bmechanism of oxaliplatin-dependen neuropathy.. In: 3rd International Congress on Neuropathic Pain (NeuPSIG), Atene - Grecia, 27-30 Maggio, pp. 0-0.

Ghelardini C; Desaphy JF; Muraglia M; Corbo F; Matucci R; Dipalma A; Bertucci C; Pistolozzi M; Nesi M; Norcini M; Franchini C; Camerino DC. (2010). Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models.. NEUROSCIENCE, vol. 169, pp. 863-873, ISSN:0306-4522

L. Bonaccini; T. Mello; C. Ghelardini; E. Sgambati; L. Di Cesare Mannelli; A. Pacini (2010). Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115, pp. 23-23, ISSN:1122-6714

D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; C. Ghelardini; E. Traini; F. Amenta (2010). Morpho-functional evaluation of the activity of stereoisomers of the antioxidant alpha-lipoic (tioctic) acid in a model of compressive neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 115, pp. 166-166, ISSN:1122-6714

A.Pacini; L.Di Cesare Mannelli; L.Bonaccini; S.Ronzoni; A.Bartolini; C.Ghelardini (2010). Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. PAIN, vol. 150, pp. 542-549, ISSN:0304-3959 DOI

C. Ghelardini; L. Di Cesare Mannelli; L. Bonaccini; A. Pacini; A. Bartolini (2010). Oxaliplatin-induced neuropathy: glial activation in spinal cord and brain.. In: 16th World Congress of Basic and Clinical Pharmacology, Copenaghen - Danimarca, 17-23 Luglio, pp. 0-0.

Isacchi B; Fabbri V; Ghelardini C; Salvicchi A; Vivoli E; Karioti A; Bergonzi MC; Bilia AR (2010). Antihyperalgesice activity of Salvianolic acid B and its formulations in the chronic constriction injury of the sciatic nerve (CCI) model of neuropathic pain. PLANTA MEDICA, pp. 1187-1187, ISSN:0032-0943

M. Bragagni ; F. Maestrelli ; N. Mennini ; C. Ghelardini ; P. Mura (2010). Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anaesthetic efficacy. JOURNAL OF LIPOSOME RESEARCH, vol. 20, pp. 315-322, ISSN:0898-2104 DOI

G. Guerrini; G. Ciciani; F. Bruni; S. Selleri; C. Guarino; F. Melani; M. Montali; S. Daniele; C. Martini; C. Ghelardini; M. Norcini; S. Ciattini; A. Costanzo (2010). New fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide system: evaluation of fluorine binding properties in the benzodiazepine site on gamma-aminobutyrric acid type A (GABAA) receptor. Design, synthesis, biological evaluation, and molecular modeling investigation.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, pp. 7532-7548, ISSN:1520-4804 DOI

Di Cesare Mannelli L.; Ghelardini C.; Toscano A.; Pacini A.; Bartolini A. (2010). The neuropathy-protective agent acetyl-L-carnitine actives PKC-gamma and MAPKs in a rat model of neuropathic pain.. NEUROSCIENCE, vol. 165, pp. 1345-1352, ISSN:0306-4522 DOI

M C Bergonzi;B Isacchi;R Iacopi;C Ghelardini;N Galeotti;M Norcini;E Vivoli;F F Vincieri;A R Bilia (2009). Antihyperalgesic activity of verbascoside in the chronic constriction injury of the sciatic nerve (CCI) and intra-articular injection of sodium monoiodoacetate (MIA) models of neuropatic pain. PLANTA MEDICA, vol. 75, pp. 45-45, ISSN:0032-0943 DOI

B. Isacchi; N. Galeotti; M. C. Bergonzi; C. Ghelardini; A.R. Bilia; F.F. Vincieri (2009). Pharmacological in vivo test to evaluate the bioavailability of some St. John’s wort innovative oral preparations. PHYTOTHERAPY RESEARCH, vol. 11, pp. 197-205, ISSN:0951-418X DOI

P. Luciani; D. Berti; M. Fortini; P. Baglioni; C. Ghelardini; A. Pacini; D. Manetti; F. Gualtieri; A. Bartolini; L. Di Cesare Mannelli (2009). Receptor-independent modulation of reconstituted Galphai protein mediated by liposomes. MOLECULAR BIOSYSTEMS, vol. 5, pp. 356-367, ISSN:1742-206X DOI

L. Di Cesare Mannelli; C. Ghelardini; M. Calvani; R. Nicolai; L. Mosconi; A. Toscano; A. Pacini; A. Bartolini (2009). Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 87, pp. 200-207, ISSN:0360-4012 DOI

Martini, Elisabetta; Salvicchi, A.; Ghelardini, Carla; Manetti, Dina; Dei, Silvia; Guandalini, Luca; Martelli, Cecilia; Melchiorre, Michele; Cellai, Cristina; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2009). Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, pp. 7606-7614, ISSN:1464-3391 DOI

E. Bianchi;M. Norcini;A. Smrcka;C. Ghelardini (2009). Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.. JOURNAL OF NEUROCHEMISTRY, vol. 111, pp. 171-180, ISSN:0022-3042 DOI Accesso ONLINE all'editore

A. Pacini; L. Di Cesare Mannelli; L. Bonaccini; A. Toscano; C. Ghelardini; P. Pacini (2009). Glial activation and nervous tissue alteration: oxaliplatin-induced neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114, pp. 168-168, ISSN:1122-6714

F. Amenta; D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; K. Tayebaty; E. Traini; C. Ghelardini (2009). Tioctic acid as a possible neuroprotective agent in an animal model of neuropathy. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 114, pp. 17-17, ISSN:1122-6714

L. Di Cesare Mannelli; A. Pacini; C. carovani; C. Ghelardini; A. Bartolini (2009). Oxaliplatin-induced neuropathic pain: glial activation and characteristic nervous tiossue alteration.. In: 34° Congresso della Società Italiana di Farmacologia, Rimini, 14-17 Ottobre, pp. 0-0.

Di Cesare Mannelli, Lorenzo; Bartolini, A.; Ghelardini, C. (2009). Neuropathy-induced apoptosis: Protective effect of physostigmine. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 87, pp. 1871-1876, ISSN:0360-4012 DOI Accesso ONLINE all'editore

Dina Manetti; Lorenzo Di Cesare Mannelli; Silvia Dei; Luca Guandalini; Elisabetta Martini; Martina Banchelli; Carla Ghelardini (2009). [35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, pp. 2224-2229, ISSN:0960-894X DOI

Failli P; Bani D; Cantore M; Di Cesare Mannelli L; Ghelardini C; Giorgi C; Innocenti M; Udisti R; Rugi F; Spepi A;Valtancoli B; Bencini A. (2009). A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 7273-7283, ISSN:0022-2623 DOI Accesso ONLINE all'editore

C. Ghelardini; N. Galeotti; E. Vivoli; I. Grazioli; C. Uslenghi (2009). The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model.. THE JOURNAL OF HEADACHE AND PAIN, vol. 10, pp. 435-440, ISSN:1129-2377 DOI Accesso ONLINE all'editore

Elisabetta Martini; Carla Ghelardini; Monica Norcini; Dina Manetti; Silvia Dei; Serena Scapecchi; Elisabetta Teodori; Maria Novella Romanelli (2009). Design, synthesis and pharmacological evaluation of novel analogues of the two nootropics unifiram (DM232) and sunifiram (DM235). In: III Meeting Nuova prospettive in chimica farmaceutica, Il Ciocco, Castelvecchio Pascoli (LU), 13-14 febbraio 2009, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. C2.P15-C2.P15.

L. Bonaccini; L. Di Cesare Mannelli; C. Ghelardini; A. Pacini (2009). Morphological and functional modifications of the nervous system in a rat model of oxaliplatin-dependent neuropathy.. In: National Symposium on peripheral nerve repair and regeneration, Torino, 4-5 Dicembre, pp. 0-0.

M. Giovannoni; C. Ghelardini; C. Vergelli; V. Dal Piaz (2009). Alpha-2-agonist as analgesic agents. MEDICINAL RESEARCH REVIEWS, vol. 29, pp. 339-368, ISSN:0198-6325

F.Maestrelli; G.Capasso; M.L.González-Rodrıguez; A.M.Rabasco; C. Ghelardini; P.Mura (2009). Effect of preparation technique on the properties and in vivo effect of benzocaine-loaded ethosomes. JOURNAL OF LIPOSOME RESEARCH, vol. 19, pp. 253-260, ISSN:0898-2104 DOI

Luigi Janiri; Giovanni Martinotti; Federico Tonioni; Carla Ghelardini; Raffaella Nicolai; Nicoletta Galeotti; Luigi Mosconi; Menotti Calvani; Alessandro Bartolini; Emerenziana Iannoni (2009). Acetyl-l-Carnitine in the Management of Pain During Methadone Withdrawal Syndrome.. CLINICAL NEUROPHARMACOLOGY, vol. 32, pp. 35-40, ISSN:0362-5664 DOI Accesso ONLINE all'editore

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S.Selleri; C. Guarino; F. Melani; M. Montali; C: Martini; C. Ghelardini; M. Norcini; A. Costanzo (2009). Synthesis, in vivo evaluation, and molecular modeling studies of new pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide derivatives. Identification of a bifunctional hydrogen bond area related to the inverse-agonism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, pp. 4668-4682, ISSN:0022-2623 DOI

M. Norcini;E. Vivoli;N. Galeotti;E. Bianchi;A. Bartolini;C. Ghelardini (2009). Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat.. PAIN, vol. 146, pp. 141-147, ISSN:0304-3959 DOI Accesso ONLINE all'editore

Nicoletta Galeotti; Elisa Vivoli; Alessandro Bartolini; Carla Ghelardini (2008). A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.. JOURNAL OF NEUROCHEMISTRY, vol. 106, pp. 2385-2394, ISSN:0022-3042 DOI Accesso ONLINE all'editore

G. Guerrini; G. Ciciani; G. Cambi; F. Bruni; S. Selleri; F. Melani; M. Montali; C. Martini; C. Ghelardini; M. Norcini; A. Costanzo (2008). Novel 3-aroylpyrazolo[5,1-c][1,2,4] benzotriazines 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modelling studies.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 4471-4489, ISSN:1464-3391 DOI

Martini, Elisabetta; Norcini, Monica; Ghelardini, Carla; Manetti, Dina; Dei, Silvia; Guandalini, Luca; Melchiorre, Michele; Pagella, Simona; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2008). Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 10034-10042, ISSN:1464-3391 DOI

Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2008). Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 1431-1443, ISSN:1464-3391 DOI

N. Galeotti; E. Vivoli; M. Norcini; A. Bartolini; C. Ghelardini (2008). An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.. NEUROPHARMACOLOGY, vol. 55, pp. 1156-1164, ISSN:0028-3908 DOI Accesso ONLINE all'editore

A. Pacini; A. Toscano; L. Bonaccini; P. Pacini; Ghelardini C.; L. Di Cesare Mannelli (2008). Protective effect of alpha7 NACHR: morphological features on neuropathy.. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113, pp. 216-216, ISSN:1122-6714

D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; A. Toscano; E. Baldoni; C. Ghelardini; F. Amenta (2008). Protective effects of acetyl-L-carnitine in sciatic nerve following loose ligation: a functional and morphological study.. In: XVIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 21-22 Novembre, pp. 0-0.

L. Di Cesare Mannelli; A. Pacini; L. Bonaccini; M. Bercigli; A. Toscano; A. Bartolini; C. Ghelardini; (2008). Alpha7 nAChR agonists: anti-hyperalgesic and neuroprotective role on neuropathy.. In: XVIII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 21-22 Novembre, pp. 0-0.

E Bianchi; N Galeotti; C Ghelardini; M Guarna (2008). Hypericum and derivatives thereof as analgesic potentiating agents. Numero: WO Patent 2008058938, 2008 Università degli Studi di Siena

N. Galeotti; A. Quattrone; E. Vivoli; A. Bartolini; C. Ghelardini (2008). Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: An antisense study.. NEUROSCIENCE, vol. 153, pp. 814-822, ISSN:0306-4522 DOI Accesso ONLINE all'editore

Carla Ghelardini; Nicoletta Galeotti; Elisa Vivoli; Monica Norcini; Wei Zhu; George B Stefano; Massimo Guarna; Enrica Bianchi (2008). Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.. JOURNAL OF NEUROCHEMISTRY, vol. 105, pp. 91-100, ISSN:0022-3042 DOI Accesso ONLINE all'editore

Carlo Farina; Stefania Gagliardi; Carla Ghelardini; Marisa Martinelli; Monica Norcini; Carlo Parini; Paola Petrillo; Silvano Ronzoni (2008). Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, pp. 3224-3232, ISSN:0968-0896 Accesso ONLINE all'editore

E. Vivoli; M. Norcini; M.Bercigli; A. Maidecchi; A.R. Bilia; C. Ghelardini (2008). Antihyperalgesic Effect of Eschscholzia californica in Rat Models of Neuropatic Pain.. NATURAL PRODUCT COMMUNICATIONS, vol. 3, pp. 2099-2102, ISSN:1934-578X

Maurizio Anzini; Michele Rovini; Andrea Cappelli; Salvatore Vomero; Fabrizio Manetti; Maurizio Botta; Lidia Sautebin; Antonietta Rossi; Carlo Pergola; Carla Ghelardini; Monica Norcini; Antonio Giordani; Francesco Makovec; Paola Anzellotti; Paola Patrignani; Mariangela Biava (2008). Synthesis, biological evaluation, and enzyme docking simulations of 1,5-diarylpyrrole-3-alkoxyethyl ethers as selective cyclooxygenase-2 inhibitors endowed with anti-inflammatory and antinociceptive activity.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, pp. 4476-4481, ISSN:0022-2623 Accesso ONLINE all'editore

E. Martini; C. Ghelardini; M. Norcini; D. Manetti; S. Dei; L. Guandalini; M. Melchiorre; S. Scapecchi; E. Teodori; F. Gualtieri; M.N. Romanelli (2008). Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. In: XIX National Meeting on Medicinal Chemistry, Verona, 14-18/09/08, Italian Chemical Society Division of Medicinal Chemistry, pp. 129-129.

D. Tomassoni; L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; F. Amenta (2008). Morphological changes of sciatic nerve following loose ligation: protective effects of acetyl-L-carnitine. ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY, vol. 113, pp. 273-273, ISSN:1122-6714

Nicoletta Galeotti; Alessandro Quattrone; Elisa Vivoli; Monica Norcini; Alessandro Bartolini; Carla Ghelardini (2008). Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.. LEARNING & MEMORY, vol. 15, pp. 315-323, ISSN:1072-0502 DOI Accesso ONLINE all'editore

G. GUERRINI; G. CICIANI; G. CAMBI; F. BRUNI; S. SELLERI; F. BESNARD; M. MONTALI; C. MARTINI; C. GHELARDINI; N. GALEOTTI; A. COSTANZO (2007). Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist, useful tools for therapy of mnemonic damage.. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, pp. 2573-2586, ISSN:0968-0896 DOI Accesso ONLINE all'editore

L. GUANDALINI; M. NORCINI; K. VARANI; M. PISTOLOZZI; C. GOTTI; C. BAZZICALUPI; E. MARTINI; S. DEI; D. MANETTI; S. SCAPECCHI; E. TEODORI; C. BERTUCCI; C. GHELARDINI; M. N. ROMANELLI (2007). Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 4993-5002, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671: DOI

L. Di Cesare Mannelli; C. Ghelardini; M. Calvani; R. Nicolai; L. Mosconi; E. Vivoli; A. Pacini; A. Bartolini (2007). Protective effect of Acetyl-L-Carnitine on the apoptotic pathway of peripheral neuropathy. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 26, pp. 820-827, ISSN:0953-816X DOI

L. Raimondi; C. Alfarano; A. Pacini; S. Livi; C. Ghelardini; G. Desiena; R. Pirisino (2007). Methylamine-dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats. BRITISH JOURNAL OF PHARMACOLOGY, vol. 150, pp. 1003-1010, ISSN:0007-1188 DOI

Filomena Corbo; Carlo Franchini; Giovanni Lentini; Marilena Muraglia; Carla Ghelardini; Rosanna Matucci; Nicoletta Galeotti; Elisa Vivoli; Vincenzo Tortorella (2007). Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 1907-1915, ISSN:0022-2623 DOI Accesso ONLINE all'editore

P.Mura; F.Maestrelli; M.L.Gonzalez Rodriguez; I.Michelacci; C.Ghelardini; A.M.Rabasco (2007). Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 67, pp. 86-95, ISSN:0939-6411, Editore attuale: ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE. Medpharm Scientific Publishers GmBH:Postfach 101061, D-70009 Stuttgart Germany:011 49 711 25820, EMAIL: service@medpharm.de, INTERNET: http://www.medpharm.de, Fax: 011 49 711 2582290: DOI

M.GIOVANNONI; N.CESARI; C.VERGELLI; A.GRAZIANO; C.BIANCALANI; P.BIAGINI; C.GHELARDINI; E.VIVOLI; V.DAL PIAZ (2007). 4-Amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, pp. 3945-3953, ISSN:0022-2623 DOI

L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; A. Bartolini (2007). Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: nicotinic receptor role.. In: XVII Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Catania, 16-17 Novembre, pp. 0-0.

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; F. Gualtieri; S. Scapecchi; E. Teodori; M.N.Romanelli (2007). Progettazione, sintesi e valutazione farmacologica preliminare di analoghi strutturali di Sunifiram e Sapunifiram, due potemti agenti nootropi. In: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Chieti, 16-20 Settembre 2007, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 146-146.

L. Raimondi; C. Ghelardini; F. Gualtieri; L. Guandalini; D. Manetti; E. Martini; M.N. Romanelli (2007). DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes. In: Frontiers in CNS and Oncology Medicinal Chemistry, Siena, 7-9 Ottobre 2007, Italian Chemical Society Division of Medicinal Chemistry, European Federation for Medicinal Chemistry, pp. 47-47.

N. Galeotti; A. Quattrone; E. Vivoli; A. Bartolini; C. Ghelardini (2007). Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.. NEUROSCIENCE, vol. 149, pp. 409-420, ISSN:0306-4522 DOI Accesso ONLINE all'editore

L. Guandalini; M. Norcini; K. Varani; M. Pistolozzi; E. Martini; S. Dei; F. Gualtieri; D. Manetti; S. Scapecchi; E. Teodori; C. Ghelardini; M.N. Romanelli (2007). Synthesis and pharmacological evaluation of new nicotinic ligands carrying a quinoline nucleus. In: 16th Camerino-Noordwijkerhout symposium, Camerino, 9-13 Settembre 2007, Università degli Studi di Camerino, pp. 99-99.

Di Cesare Mannelli, L.; Pacini, A.; Toscano, A.; Fortini, M.; Berti, D.; Ghelardini, C.; Galeotti, N.; Baglioni, P.; Bartolini, A. (2006). Gi/o proteins: expression for direct activation enquiry. PROTEIN EXPRESSION AND PURIFICATION, vol. 47, pp. 303-310, ISSN:1046-5928, Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445 ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, USA, CA, 92101-4495: DOI

L. DI CESARE MANNELLI; A. PACINI; A. TOSCANO; C. GHELARDINI; D. MANETTI; F. GUALTIERI; T. PATEL; A. BARTOLINI (2006). A recombinant transductor-effector system: in vitro study of G inhibitor protein (G-alfa-i1)direct activators. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 453, pp. 151-160, ISSN:0003-9861 DOI

V. COLOTTA; D. CATARZI; F. VARANO; O. LENZI; G. FILACCHIONI; C. COSTAGLI; A. GALLI; C. GHELARDINI; N. GALEOTTI; P.GRATTERI; J.SGRIGNANI; F. DEFLORIAN; S. MORO; (2006). Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 6015-6026, ISSN:0022-2623 DOI Accesso ONLINE all'editore

N.CESARI; C.BIANCALANI; C.VERGELLI; V. DAL PIAZ; A.GRAZIANO; P.BIAGINI; C.GHELARDINI; N.GALEOTTI; M.GIOVANNONI (2006). Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, pp. 7826-7835, ISSN:0022-2623 DOI

GALEOTTI N; A. BARTOLINI; GHELARDINI C (2006). Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test.. NEUROPHARMACOLOGY, vol. 50, pp. 309-316, ISSN:0028-3908, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI Accesso ONLINE all'editore

M. ROMANELLI; N. GALEOTTI; C. GHELARDINI; D. MANETTI; E. MARTINI; F. GUALTIERI (2006). Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers. CNS DRUG REVIEWS, vol. 12, pp. 39-52, ISSN:1080-563X DOI

L. Cioni; G. De Siena; C. Ghelardini; O. Sernissi; C. Alfarano; R. Pirisino; L. Raimondi (2006). Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 529, pp. 179-187, ISSN:0014-2999, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598: DOI Accesso ONLINE all'editore

L. Di Cesare Mannelli; A. Pacini; A. Toscano; C. Ghelardini; A. Bartolini (2006). Antiapoptotic effect of physostigmine in a peripheral neuropathy model.. In: XVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 23-24 Novembre, pp. 0-0.

L.Guandalini; E.Martini; P.Gratteri; C.Ghelardini; K.Varani; M.Romanelli (2006). Design, synthesis and binding affinity of new nicotinic ligands. ARKIVOC, vol. viii, pp. 50-65, ISSN:1551-7004

Nicoletta Galeotti; George B Stefano; Massimo Guarna; Enrica Bianchi; Carla Ghelardini (2006). Signaling pathway of morphine induced acute thermal hyperalgesia in mice.. PAIN, vol. 123, pp. 294-305, ISSN:0304-3959 DOI Accesso ONLINE all'editore

Renato Pirisino; Nicoletta Galeotti; Silvia Livi; Laura Raimondi; Carla Ghelardini (2006). 4-methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain Shaker-like Kv1.1 channels.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 147, pp. 218-224, ISSN:0007-1188 DOI Accesso ONLINE all'editore

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; F. Gualtieri; S. Scapecchi; E. Teodori; M.N. Romanelli (2006). Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators. In: XXII Congresso Nazionale della Società Chimica Italiana, Firenze, 10-15 Settembre 2006, Società Chimica Italiana, pp. 195-195.

A R Bilia; M C Bergonzi; B Isacchi; N Galeotti; C Ghelardini; F F Vincieri (2006). Pharmacological in vivo test to evaluate the bioavailability of some St. John's wort innovative oral preparations. PLANTA MEDICA, vol. 72, pp. 241-241, ISSN:0032-0943 DOI

Massimo Guarna; Carla Ghelardini; Nicoletta Galeotti; George B Stefano; Enrica Bianchi (2005). Neurotransmitter role of endogenous morphine in CNS.. MEDICAL SCIENCE MONITOR, vol. 11, pp. RA190-RA193, ISSN:1234-1010

Pirisino R;Ghelardini C;De Siena G;Malmberg P;Galeotti N;Cioni L;Banchelli G;Raimondi L (2005). Methylamine: a new endogenous modulator of neuron firing?. MEDICAL SCIENCE MONITOR, vol. 11, pp. 257-261, ISSN:1234-1010

A Bartolini; C Ghelardini; N Galeotti (2005). Analgesic drugs acting through a central cholinergic mechanism. In: A Capasso. Recent Developments in Pain Research, pp. 289-312, Fisciano: A Capasso, ISBN:8130800128.

D. Manetti; L. Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M. Romanelli; S. Scapecchi; E. Teodori; A. Pacini; A. Bartolini; F. Gualtieri (2005). Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, pp. 6491-6503, ISSN:0022-2623 DOI

Martini, Elisabetta; Ghelardini, Carla; Bertucci, C.; Dei, Silvia; Gualtieri, Fulvio; Guandalini, Luca; Manetti, Dina; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, MARIA NOVELLA (2005). Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent. MEDICINAL CHEMISTRY, vol. 1, pp. 473-480, ISSN:1573-4064

A. Toscano; L. Di Cesare Mannelli; C. Ghelardini; N. galeotti; A. bartolini; A. Pacini (2005). Transductor-effector system as model for the study of Gi protein dysfunction treatment.. In: XV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (GISN), Bologna, 24-25 Novembre, Gruppo Italiano per lo Studio della Neuromorfologia (GISN), pp. 0-0.

Nicoletta Galeotti; Alessandro Bartolini; Carla Ghelardini (2005). Ryanodine receptors are involved in muscarinic antinociception in mice.. BEHAVIOURAL BRAIN RESEARCH, vol. 164, pp. 165-171, ISSN:0166-4328 DOI Accesso ONLINE all'editore

Cioni L, De Siena G, Ghelardini C, Sernissi O, Alfarano C, Pirisino R, Raimondi L. (2005). Activity and expression of semicarbazide-sensitive amine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-amino guanidine. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 4, pp. 179-187, ISSN:0014-2999, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

R. Pirisino; C. Ghelardini; A. Pacini; N. Galeotti; L. Raimondi (2004). Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 142, pp. 381-389, ISSN:0007-1188 DOI

Teodori, Elisabetta; Baldi, Elisabetta; Dei, Silvia; Gualtieri, Fulvio; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Bellucci, Cristina; Ghelardini, Carla; Matucci, Rosanna (2004). Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, pp. 6070-6081, ISSN:0022-2623, American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671: DOI

Nicoletta Galeotti; Petra Malmberg-Aiello; Alessandro Bartolini; Walter Schunack; Carla Ghelardini (2004). H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.. NEUROPHARMACOLOGY, vol. 47, pp. 295-303, ISSN:0028-3908 DOI Accesso ONLINE all'editore

C. GHELARDINI; N. GALEOTTI; C. USLENGHI; I. GRAZIOLI; A. BARTOLINI (2004). Prochlorperazine induces central antinociception mediated by the muscarinic system.. PHARMACOLOGICAL RESEARCH, vol. 50, pp. 351-358, ISSN:1043-6618 DOI

GUARNA M; GHELARDINI C; GALEOTTI N; A. BARTOLINI; NOLI L; NERI C; STEFANO GB; BIANCHI E (2004). Effect of endogenous morphine deprivation on memory retention of passive avoidance learning in mice.. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, vol. 7, pp. 311-319, ISSN:1461-1457 DOI

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2004). Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype.. BEHAVIOURAL BRAIN RESEARCH, vol. 153, pp. 409-417, ISSN:0166-4328 DOI

D. Manetti; L.Di Cesare Mannelli; S. Dei; N. Galeotti; C. Ghelardini; M.N. Romanelli; S. Scapecchi; E. Teodori; A. Bartolini; F. Gualtieri (2004). Progettazione, sintesi e valutazione farmacologica preliminare di attivatori diretti delle proteine Gi. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 249-249.

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2004). Role of intracellular calcium in acute thermal pain perception. NEUROPHARMACOLOGY, vol. 47, pp. 935-944, ISSN:0028-3908 DOI Accesso ONLINE all'editore

S. SCAPECCHI; E. MARTINI; D. MANETTI; C. GHELARDINI; C. MARTELLI; S. DEI; N. GALEOTTI; L. GUANDALINI; M. ROMANELLI; E. TEODORI (2004). Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, pp. 71-85, ISSN:0968-0896 DOI

Nicoletta Galeotti; Alessandro Bartolini; Menotti Calvani; Raffaella Nicolai; Carla Ghelardini (2004). Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception.. NEUROPHARMACOLOGY, vol. 47, pp. 286-294, ISSN:0028-3908 DOI Accesso ONLINE all'editore

E. Martini; C. Ghelardini; D. Manetti; S. Dei; L. Guandalini; C. Martelli; S. Scapecchi; E. Teodori; M.N.Romanelli (2004). Sintesi chirale e valutazione farmacologica preliminare degli enantiomeri di DM232 e MC68, due azabiciclononanoni modulatori dei processi cognitivi. In: XVII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana, Pisa, 6-10 Settembre 2004, Società Chimica Italiana, pp. 182-182.

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2004). Alpha-2 agonits induce amnesia through activation of the Gi-protein signalling pathway.. NEUROSCIENCE, vol. 126, pp. 451-460, ISSN:0306-4522 DOI

Carla Ghelardini; Nicoletta Galeotti; Irene Grazioli; Carla Uslenghi (2004). Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine.. THE JOURNAL OF PAIN, vol. 5, pp. 413-419, ISSN:1526-5900 DOI Accesso ONLINE all'editore

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2003). Diphenhydramine-induced amnesia is mediated by Gi-protein activation.. NEUROSCIENCE, vol. 122, pp. 471-478, ISSN:0306-4522 DOI

GIOVANNONI M.P.; VERGELLI C.; GHELARDINI C.; GALEOTTI N.; BARTOLINI A.; V. DAL PIAZ (2003). [(3-chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 1055-1059, ISSN:0022-2623 DOI

Maurizio Anzini; Laura Canullo; Carlo Braile; Andrea Cappelli; Andrea Gallelli; Salvatore Vomero; M. Cristina Menziani; Pier G De; Milena Rizzo; Simona Collina; Ornella Azzolina; Massimo Sbacchi; Carla Ghelardini; Nicoletta Galeotti (2003). Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, pp. 3853-3864, ISSN:0022-2623 DOI Accesso ONLINE all'editore

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2003). THE PHOSPHOLIPASE C-IP3 PATHWAY IS INVOLVED IN MUSCARINIC ANTINOCICEPTION. NEUROPSYCHOPHARMACOLOGY, vol. 28, pp. 888-897, ISSN:0893-133X DOI

M. Guarna; A. Bartolini; C. Ghelardini; N. Galeotti; L. Bracci; G. B. Stefano; E. Bianchi (2003). Anti-mu opioid antiserum against the third external loop of the cloned mu-opioid receptor acts as a mu receptor neutral antagonist.. MOLECULAR BRAIN RESEARCH, vol. 119, pp. 100-110, ISSN:0169-328X DOI Accesso ONLINE all'editore

Elisabetta Teodori; Elisabetta Baldi; Cristina Bellucci; Silvia Dei; Carla Ghelardini; Fulvio Gualtieri; Rosanna Matucci; Maria Novella Romanelli; Serena Scapecchi (2003). Design, synthesis and preliminary pharmacological evaluation of alkylderivatives of 4-aminopiperidine as N-type calcium channels blockers. In: XXI Congresso Nazionale della Società Chimica Italiana SCI2003, Torino, 22-27 giugno 2003, Società Chimica Italiana, pp. FA-CO-021-FA-CO-021.

S. SCAPECCHI; C. MARTELLI; C. GHELARDINI; L. GUANDALINI; E. MARTINI; F. GUALTIERI (2003). 2-PYRROLIDINONE MOIETY IS NOT CRITICAL FOR THE COGNITION ENHANCING ACTIVITY OF PIRACETAM-LIKE DRUGS. IL FARMACO, vol. 58, pp. 715-722, ISSN:0014-827X, Attuale:ELSEVIER SCIENCE SA, PO BOX 564, LAUSANNE, SWITZERLAND, 1001 Societa Chimica Italiana:Viale Liegi 48, 00198 Rome Italy:011 39 06 8549691, EMAIL: soc.chim.it@agora.stm.it, Fax: 011 39 06 8548734:

L. RAIMONDI; M. BANCHELLI; C. GHELARDINI; R. PIRISINO (2003). THE REDUCTION OF FOOD INTAKE INDUCED IN MICE BY BENZYLAMINE AND ITS DERIVATIVES. INFLAMMOPHARMACOLOGY, vol. 11, pp. 189-194, ISSN:0925-4692

D. MANETTI; E. MARTINI; C. GHELARDINI; S. DEI; N. GALEOTTI; L. GUANDALINI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI; F. GUALTIERI (2003). 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, pp. 2303-2306, ISSN:0960-894X DOI

N.GALEOTTI; C.GHELARDINI; A.PITTALUGA; A. PUGLIESE; A.BARTOLINI; D.MANETTI; M.ROMANELLI; F.GUALTIERI (2003). AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram).. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 368, pp. 538-545, ISSN:0028-1298

C. GHELARDINI; A. QUATTRONE; N. GALEOTTI; S. LIVI; G. BANCHELLI; L. RAIMONDI; R. PIRISINO. (2003). Antisense knockdown of the Shaker Kv1.1 gene family abolishes the central stimulatory effect of amphetamines in mice and rats.. NEUROPSYCHOPHARMACOLOGY, vol. 28, pp. 1096-1105, ISSN:0893-133X DOI

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (2002). ANTIHISTAMINE ANTINOCICEPTION IS MEDIATED BY GI-PROTEIN ACTIVATION. NEUROSCIENCE, vol. 109, pp. 811-818, ISSN:0306-4522 DOI

Elisabetta Teodori; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Baldi; Carla Ghelardini (2002). Synthesis and biological evaluation of 4-amino piperidines as N-type calcium channel blockers. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona, Spain, 1-5 Settembre 2002, J.R.Prous Drugs of the Future, vol. 27, Suppl. A, pp. 473-473.

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI (2002). AMITRIPTYLINE AND CLOMIPRAMINE ACTIVATE GI-PROTEIN SIGNALING PATHWAY IN THE INDUCTION OF ANALGESIA. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 365, pp. 1-7, ISSN:0028-1298 DOI

M. NICOLODI; N. GALEOTTI; C. GHELARDINI; A. BARTOLINI; F. SICUTERI (2002). CENTRAL CHOLINERGIC CHALLENGING OF MIGRAINE BY TESTING SECOND-GENERATION ANTICHOLINESTERASE DRUG. HEADACHE, vol. 42, pp. 596-602, ISSN:0017-8748 DOI

Carla Ghelardini;Nicoletta Galeotti;Fulvio Gualtieri;Dina Manetti;Corrado Bucherelli;Elisabetta Baldi;Alessandro Bartolini (2002). The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats. DRUG DEVELOPMENT RESEARCH, vol. 56, pp. 23-32, ISSN:0272-4391 DOI

Nicoletta Galeotti; Alessandro Bartolini; Carla Ghelardini (2002). Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine.. NEUROPSYCHOPHARMACOLOGY, vol. 27, pp. 554-564, ISSN:0893-133X DOI Accesso ONLINE all'editore

N. GALEOTTI; L. DI CESARE MANNELLI; G. MAZZANTINI; A. BARTOLINI; C. GHELARDINI (2002). MENTHOL: A NATURAL ANALGESIC COMPOUND. NEUROSCIENCE LETTERS, vol. 322, pp. 145-148, ISSN:0304-3940 DOI Accesso ONLINE all'editore

N. GALEOTTI; A. BARTOLINI; C. GHELARDINI (2002). Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test.. NEUROPHARMACOLOGY, vol. 43, pp. 457-465, ISSN:0028-3908 DOI

F. GUALTIERI; D. MANETTI; M. N. ROMANELLI; C. GHELARDINI (2002). Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. CURRENT PHARMACEUTICAL DESIGN, vol. 8, pp. 125-138, ISSN:1381-6128

N. GALEOTTI; C. GHELARDINI; I. GRAZIOLI; I. USLENGHI (2002). INDOMETHACIN, CAFFEINE AND PROCHLORPERAZINE ALONE AND COMBINED REVERT HYPERALGESIA IN VIVO MODELS OF MIGRAINE. PHARMACOLOGICAL RESEARCH, vol. 46, pp. 245-250, ISSN:1043-6618 DOI

Ghelardini C.;Galeotti N.;Gualtieri F.;Romanelli M.;Bucherelli C.;Baldi E.;Bartolini A. (2002). DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 365, pp. 419-426, ISSN:0028-1298 DOI

M. GUARNA; E. BIANCHI; A. BARTOLINI; C. GHELARDINI; N. GALEOTTI; BRACCI; L. C. NERI; D. SONETTI; G. STEFANO; (2002). Endogenous morphine modulates acute thermonociception in mice.. JOURNAL OF NEUROCHEMISTRY, vol. 80, pp. 271-277, ISSN:0022-3042 DOI

C. Ghelardini; N. Galeotti; F. Gualtieri; D. Manetti; M.N. Romanelli; A. Bartolini (2002). The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats. In: COST Action D13 Workshop new molecules toward human health care, Firenze, 17-20 Aprile 2002, Università degli Studi di Firenze, pp. 52-52.

Serena Scapecchi; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Elisabetta Martini; Maria Novella Romanelli; Elisabetta Teodori; Carla Ghelardini (2002). Molecular simplification of DM232 and DM235, two new potent cognition enhancers. In: XVIIth International Symposium on Medicinal Chemistry, Barcelona (Spain), 1-5 Settembre 2002, J.R.Prous Drugs of the Future, vol. 27, Suppl. A, pp. 442-442.

C. GHELARDINI; N. GALEOTTI; M. CALVANI; L. MOSCONI; R. NICOLAI; A. BARTOLINI; (2002). ACETYL-L-CARNITINE INDUCES MUSCARINIC ANTINOCICEPTION IN MICE AND RATS. NEUROPHARMACOLOGY, vol. 43, pp. 1180-1187, ISSN:0028-3908 DOI

C. Ghelardini; N. Galeotti; C. Lelli; A. Bartolini (2001). M1 receptor activation is a requirement for arecoline analgesia.. IL FARMACO, vol. 56, pp. 383-385, ISSN:0014-827X DOI Accesso ONLINE all'editore

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (2001). Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against Gi-protein a subunits.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 133, pp. 267-274, ISSN:0007-1188 DOI

G. Banchelli; C. Ghelardini; L. Raimondi; N. Galeotti; R. Pirisino (2001). Selective inhibition of amine oxidases differently potentiate the hypophagic effect of benzylamine in mice.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 413, pp. 91-99, ISSN:0014-2999 DOI Accesso ONLINE all'editore

R Pirisino;C Ghelardini;G Banchelli;N Galeotti;L Raimondi (2001). Methylamine and benzylamine induced hypophagia in mice: Modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels. BRITISH JOURNAL OF PHARMACOLOGY, vol. 134, pp. 880-886, ISSN:0007-1188 DOI

Romanelli, MARIA NOVELLA; Manetti, Dina; Scapecchi, Serena; Borea, P.; Dei, Silvia; Bartolini, Alessandro; Ghelardini, Carla; Gualtieri, Fulvio; Guandalini, Luca; Varani, K. (2001). Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP). JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 3946-3955, ISSN:0022-2623 DOI

A Bartolini; N Galeotti; C Ghelardini; M Zoppi; E Del Bene; L Raimondi; E Beneforti (2001). Hypofunctionality of Gi proteins as aetiopathogenetic mechanism for migraine and cluster headache.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 133, pp. U31-U31, ISSN:0007-1188

C. GHELARDINI; N. GALEOTTI; L. DI CESARE MANNELLI; A. CAPPELLI; M. ANZINI; A. BARTOLINI (2001). ANTIAMNESIC EFFECT OF THE TWO NOVEL K-OPIOID AGONISTS, VA-100 AND VA-101, IN THE MOUSE PASSIVE AVOIDANCE TEST. DRUG DEVELOPMENT RESEARCH, vol. 54, pp. 12-18, ISSN:0272-4391 DOI

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (2001). Involvement of potassium channels in amitriptyline and clomipramine analgesia.. NEUROPHARMACOLOGY, vol. 40, pp. 75-84, ISSN:0028-3908 DOI

C. GHELARDINI; N. GALEOTTI; G. MAZZANTI (2001). LOCAL ANAESTHETIC ACTIVITY OF MONOTERPENES AND PHENYLPROPANES OF ESSENTIAL OILS. PLANTA MEDICA, vol. 67, pp. 564-566, ISSN:0032-0943 DOI

C. Ghelardini;N. Galeotti;L. Di Cesare Mannelli;G. Mazzanti;A. Bartolini (2001). Local anaesthetic activity of beta-caryophyllene.. IL FARMACO, vol. 56, pp. 387-389, ISSN:0014-827X DOI

N. GALEOTTI; C. GHELARDINI; L. DI CESARE MANNELLI; A. BARTOLINI (2001). ANTINOCICEPTIVE PROFILE OF THE NATURAL CHOLINESTERASE INHIBITOR HUPERZINE A. DRUG DEVELOPMENT RESEARCH, vol. 54, pp. 19-26, ISSN:0272-4391 DOI Accesso ONLINE all'editore

C. MELCHIORRE; M: BOLOGNESI; R. BUDRIESI; C. GHELARDINI; A. CHIARINI; A. MINARINI; M. ROSINI; V. TUMIATTI; E. WADE (2001). DESIGN,SYNTHESIS AND BIOLOGICAL ACTIVITY OF METHOCTRAMINE-RELATED POLYAMINES AS PUTATIVE GI PROTEIN ACTIVATORS. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, pp. 4035-4038, ISSN:0022-2623

A Bartolini; E Beneforti; N Galeotti; C Ghelardini; M Zoppi (2001). Diagnostic method for algic pathologies. Numero: EP Patent 1,076,825,2001 Università degli Studi di Firenze

Galeotti, Nicoletta; Ghelardini, Carla; Zoppi, M.; DEL BENE, Enrico; Raimondi, Laura; Beneforti, Elisabetta; Bartolini, Alessandro (2001). A REDUCED FUNCTIONALITY OF GI PROTEINS AS A POSSIBLE CAUSE FOR FIBROMYALGIA. THE JOURNAL OF RHEUMATOLOGY, vol. 28, pp. 2298-2304, ISSN:0315-162X Accesso ONLINE all'editore

A Bartolini; C Bellucci; N Galeotti; C Ghelardini; F Gualtieri; D Manetti (2001). Piperazine derivatives possessing nootropic activity. Numero: EP1118612, 2001. Università degli Studi di Firenze

L. Guandalini; M.N. Romanelli; S. Scapecchi; D. Manetti; S. Dei; E. Teodori; F. Gualtieri; C. Ghelardini; A. Bartolini; K. Varani; P.A. Borea (2001). Design, synthesis and pharmacological evaluation of DMPP analogues to explore the Nicotinic receptor binding site. In: 13th Noordwijkerhout-Camerino Symposium Trends in drug research, Noordwijkerhout, the Netherlands, 6-11 May 2001, Division Pharmacochemistry of the Royal Netherlands Chemical Society, European Federation for Medicinal Chemistry, pp. 57-57.

N. GALEOTTI; C. GHELARDINI; M. ZOPPI; E. DEL BENE; L. RAIMONDI; E. BENEFORTI; A. BARTOLINI (2001). HYPOFUNCTIONALITY OF GI PROTEINS AS AETIOPHATOGENETIC MECHANISM FOR MIGRAINE AND CLUSTER HEADACHE. CEPHALALGIA, vol. 21, pp. 38-45, ISSN:0333-1024 DOI Accesso ONLINE all'editore

N. GALEOTTI; C. GHELARDINI; L. DI CESARE MANNELLI; G. MAZZANTI; L. BAGHIROLI; A. BARTOLINI (2001). LOCAL ANAESTHETIC ACTIVITY OF (+) AND (-) MENTHOL. PLANTA MEDICA, vol. 67, pp. 174-176, ISSN:0032-0943 DOI Accesso ONLINE all'editore

Dina Manetti; Carla Ghelardini; Alessandro Bartolini; Cristina Bellucci; Silvia Dei; Nicoletta Galeotti; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori (2000). 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. In: 7th IBN SINA International Conference on pure and applied heterocyclic chemistry, Alexandria, Egypt, 25-28 March 2000, Chemistry Department Faculty of Science, pp. IL-51-IL-51.

GHELARDINI C; GALEOTTI N; A. BARTOLINI (2000). Loss of muscarinic antinociception by antisense inhibition of M1 receptors.. BRITISH JOURNAL OF PHARMACOLOGY, vol. 129, pp. 1633-1640, ISSN:0007-1188 DOI

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (2000). ROLE OF 5-HT1A RECEPTORS IN A MOUSE PASSIVE AVOIDANCE PARADIGM. JAPANESE JOURNAL OF PHARMACOLOGY, vol. 84, pp. 418-424, ISSN:0021-5198 DOI Accesso ONLINE all'editore

P. DOLARA; B. CORTE; C. GHELARDINI; A.M. PUGLIESE; E. CERBAI; S. MENICHETTI; A. LO NOSTRO (2000). Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.. PLANTA MEDICA, vol. 66, pp. 356-358, ISSN:0032-0943 DOI

C. GHELARDINI; N. GALEOTTI; M. ROMANELLI; F. GUALTIERI; A. BARTOLINI (2000). PHARMACOLOGICAL CHARACTERIZATION OF THE NOVEL ACH RELEASER A-TROPANYL 2-(4-BROMOPHENYL)PROPIONATE (PG-9).. CNS DRUG REVIEWS, vol. 6, pp. 63-78, ISSN:1080-563X

C. GHELARDINI; N. GALEOTTI; L. DI CESARE MANNELLI; S. DEI; F. GUALTIERI; A. BARTOLINI (2000). AG-4:A NICOTINIC AGONIST ENDOWED WITH ANTIAMNESIC PROPERTIES. DRUG DEVELOPMENT RESEARCH, vol. 51, pp. 191-196, ISSN:0272-4391 DOI

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI (2000). PHARMACOLOGICAL IDENTIFICATION OF SM-21, THE NOVEL SIGMA2 ANTAGONIST. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 67, pp. 659-662, ISSN:0091-3057 DOI

A Bartolini; L Di Cesare Mannelli; N Galeotti; C Lelli; S Livi; C Uslenghi; I Grazioli; C Ghelardini (2000). Un’aumentata liberazione di acetilcolina alla base dell’effetto analgesico indotto da proclorperazina. In: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti. : Nuove prospettive nella terapia delle Cefalee, pp. 357-359, Firenze: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti.

G. BANCHELLI; L. RAIMONDI; C. GHELARDINI; R. PIRISINO; V. BERTINI; A. DE MUNNO; F. LUCCHESINI (2000). Benzylamine-related compounds stimulate rat was deferens neurotransmission and potentiate memory in the mouse acting as potassium potassium channel blockers.. PHARMACOLOGICAL RESEARCH, vol. 41, pp. 151-162, ISSN:1043-6618

D. MANETTI; C. GHELARDINI; A. BARTOLINI; S. DEI; N. GALEOTTI; F. GUALTIERI; M. N. ROMANELLI; E. TEODORI (2000). Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 4499-4507, ISSN:0022-2623 DOI

D. MANETTI; C. GHELARDINI; A. BARTOLINI; C. BELLUCCI; S. DEI; N. GALEOTTI; F. GUALTIERI; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI (2000). Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, pp. 1969-1974, ISSN:0022-2623 DOI

C. Ghelardini; N. Galeotti; A. Bartolini (2000). Pro-cognitive activity induced in the rat by low doses of R-(+)-hyoscyamine.. FITOTERAPIA, vol. 71 Suppl 1, pp. S124-S130, ISSN:1971-551X DOI Accesso ONLINE all'editore

D. Manetti; C. Ghelardini; A. Bartolini; C. Bellucci; S. Dei; N. Galeotti; F. Gualtieri; M.N. Romanelli; S Scapecchi; E. Teodori (2000). 1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs. In: XVIth International Symposium on Medicinal Chemistry, Bologna, 18-22 Settembre 2000, Italian Chemical Society Division of Medicinal Chemistry, pp. 395-395.

C Ghelardini; N Galeotti; L Di Cesare Mannelli; M Nicolodi; F Sicuteri; C Uslenghi; I Grazioli; A Bartolini (2000). Effetto antiiperalgico della proclorperazina. In: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti. Nuove prospettive nella terapia delle Cefalee, pp. 379-381, Firenze: V. Gallai, G. Mazzotta, P. Sarchielli, A. Alberti.

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI (2000). ANTINOCICEPTION INDUCED BY AMITRIPTYLINE AND IMIPRAMINE IS MEDIATED BY A2A-ADRENOCEPTORS. JAPANESE JOURNAL OF PHARMACOLOGY, vol. 82, pp. 130-137, ISSN:0021-5198 DOI

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; S. SCAPECCHI; A. BARTOLINI (1999). IMPROVEMENT OF COGNITIVE FUNCTIONS BY THE ACETYLCHOLINE RELEASER SM21. DRUG DEVELOPMENT RESEARCH, vol. 47, pp. 118-126, ISSN:0272-4391 DOI

N. GALEOTTI; C. GHELARDINI; M.C.VINCI; A. BARTOLINI (1999). Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors. BRITISH JOURNAL OF PHARMACOLOGY, vol. 126, pp. 1214-1220, ISSN:0007-1188 DOI

GHELARDINI C.; GALEOTTI N.; MATUCCI R.; BELLUCCI C.; GUALTIERI F.; CAPACCIOLI S.; QUATTRONE A.; BARTOLINI A. (1999). Antisense knockdowns of M1 receptors induces transient anterograde amnesia in mice. NEUROPHARMACOLOGY, vol. 38, pp. 339-348, ISSN:0028-3908 DOI

C. GHELARDINI; N. GALEOTTI; L. FANTETTI; F. GUALTIERI; S. SCAPECCHI; A. BARTOLINI; (1999). ANTINOCICEPTIVE EFFECT OF R-(+)-HYOSCYAMMINE ON THE CONJUNCTIVAL REFLEX TEST IN RABBITS. JAPANESE JOURNAL OF PHARMACOLOGY, vol. 81, pp. 34-37, ISSN:0021-5198 DOI

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (1999). THE ROLE OF POTASSIUM CHANNELS IN ANTIHISTAMINE ANALGESIA. NEUROPHARMACOLOGY, vol. 38, pp. 1893-1901, ISSN:0028-3908 DOI Accesso ONLINE all'editore

C. GHELARDINI; I. MIZUMA; F. GUALTIERI; A. BARTOLINI; N. GALEOTTI; M. ROMANELLI; E. TEODORI (1999). Binding Profiles of a Series of 2-Arylpropionic Acid Esters on Cloned Human Muscarinic Receptors Subtypes (m1-m5) and Their Relationship to Nootropic Activity. ARZNEIMITTEL-FORSCHUNG, vol. 49 (I), pp. 483-488, ISSN:0004-4172

D. MANETTI; A. BARTOLINI; P. BOREA; C. BELLUCCI; S. DEI; C. GHELARDINI; F. GUALTIERI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; K. VARANI (1999). Hybridized and isosteric analogs of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, pp. 457-465, ISSN:0968-0896

V. Marchese; N. Galeotti; C. Ghelardini; A. Bartolini; D. Manetti; S. Furukawa; A. Nitta; F. Gualtieri (1999). Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the ACh releaser PG-9. In: Society for Neuroscience 29th Annual Meeting, Miami Beach, Florida, 23-28 Ottobre 1999, Society of Neuroscience, pp. 1014-1014.

N. GALEOTTI; C. GHELARDINI; B. CALDARI; A. BARTOLINI (1999). EFFECT OF POTASSIUM CHANNEL MODULATORS IN MOUSE FORCED SWIMMING TEST. BRITISH JOURNAL OF PHARMACOLOGY, vol. 126, pp. 1653-1659, ISSN:0007-1188 DOI Accesso ONLINE all'editore

C. GHELARDINI; N. GALEOTTI; G. SALVATORE; G. MAZZANTI (1999). LOCAL ANAESTHETIC AVTIVITY OF ESSENTIAL OIL OF LAVANDULA ANGUSTIFOLIA. PLANTA MEDICA, vol. 65, pp. 700-703, ISSN:0032-0943 DOI

C. GHELARDINI; N. GALEOTTI; F. GIULIANI; D. BARLOCCO; A. BARTOLINI (1998). ANTIAMNESIC ACTIVITY OF THE NICOTINIC AGONIST DBO-83 IN MICE. DRUG DEVELOPMENT RESEARCH, vol. 45, pp. 45-51, ISSN:0272-4391 DOI

S. SCAPECCHI; A. GIORGI; C. BELLUCCI; S. DEI; C. GHELARDINI; D. MANETTI; M. ROMANELLI; E. TEODORI (1998). FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY. IL FARMACO, vol. 53, pp. 764-772, ISSN:0014-827X

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI; S. FURUKAWA; A. NITTA; D. MANETTI; F. GUALTIERI (1998). Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the ACh releaser PG9. JAPANESE JOURNAL OF PHARMACOLOGY, vol. 78, pp. 245-251, ISSN:0021-5198 DOI

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI (1998). NO DEVELOPMENT OF TOLERANCE TO ANALGESIA BY REPEATED ADMINISTRATION OF H1 ANTAGONISTS. LIFE SCIENCES, vol. 63, pp. PL317-PL322, ISSN:0024-3205 DOI

C Ghelardini; N Galeotti; A Ouattrone; A Bartolini (1998). Amnesia induced in mice by ICV treatment with an aODN to the M-1 receptor subtype gene. EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 10, pp. 156-156, ISSN:0953-816X

A Bartolini; C Ghelardini; N Galeotti; C Martini (1998). Analgesia induced by H-1 antagonists is not subjected to tolerance. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 358, pp. R118-R118, ISSN:0028-1298

C Ghelardini; N Galeotti; A Bartolini (1998). Depressive behaviour induced by inhibition of mKv1.1 potassium channel expression by antisense ODN. JOURNAL OF NEUROCHEMISTRY, vol. 71, pp. S26-S26, ISSN:0022-3042

C. Ghelardini; N. Galeotti; F. Gualtieri; C. Bellucci; A. Bartolini (1998). Memory facilitation with atropine: a paradoxical effect. PHYTOTHERAPY RESEARCH, vol. 12, pp. S7-S9, ISSN:0951-418X DOI Accesso ONLINE all'editore

D. Barlocco; G. Cignarella; D. Tondi; P. Vianello; S. Villa; A. Bartolini; C. Ghelardini; N. Galeotti; D. J. Anderson; T. A. Kuntzweiler; D. Colombo; L. Toma (1998). Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.. JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, pp. 674-681, ISSN:0022-2623 DOI Accesso ONLINE all'editore

C. Ghelardini; N. Galeotti; S. Donaldson; A. Bartolini (1998). The antimigraine drug ergotamine is endowed with anti-hyperalgesic activity. PHYTOTHERAPY RESEARCH, vol. 12, pp. S10-S12, ISSN:0951-418X DOI Accesso ONLINE all'editore

D. Manetti; A. Bartolini; P.A.Borea; C. Bellucci; S. Dei; C. Ghelardini; F. Gualtieri; M.N. Romanelli; S. Scapecchi; E. Teodori; K. Varani (1998). Hybridized and isosteric analogs of N1-acetyl-N4-dimethylpiperazinium iodide (ADMP), N1-phenyl-N4-dimethylpiperazinium iodide (DMPP) with central nicotinic action. In: XVth EFMC Internatinal Symposium on Medicinal Chemistry, Edinburgh, Scotland, 6-10 Settembre 1998, Royal Society of Chemistry, European Federation for Medicinal Chemistry, pp. 138-138.

D. Manetti; A. Bartolini; P.A.Borea; C. Bellucci; S. Dei; C. Ghelardini; F. Gualtieri; M.N. Romanelli; S. Scapecchi; E. Teodori; K.Varani (1998). Hybridized and isosteric analogs of N1-acetyl-N4-dimethylpiperazinium iodide (ADMP), N1-phenyl-N4-dimethylpiperazinium iodide (DMPP) with central nicotinic action. In: XIV Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Salsomaggiore Terme-Parma, 21-25 Settembre 1998, Società Chimica Italiana, pp. 92-92.

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (1998). EFFECT OF PERTUSSIS TOXIN ON BACLOFEN-AND DIPHENHYDRAMINE- INDUCED AMNESIA. PSYCHOPHARMACOLOGY, vol. 136, pp. 328-334, ISSN:0033-3158 DOI Accesso ONLINE all'editore

E. GRATACOS; C. GHELARDINI; L.M. GHERARDINI; N. GALEOTTI; K. MURPHY; A. BARTOLINI; C. REGAN (1998). KV1.1 CHANNEL ANTISENSE ATTENUATES LEARNING AND MODULATION OF DENTATE POLYSIALYLATED NCAM. NEUROREPORT, vol. 9, pp. 2727-2731, ISSN:0959-4965 DOI

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; V. MARCHESE; C. BELLUCCI; A. BARTOLINI (1998). Antinociceptive and antiamnesic properties of the presynaptic amplifier PG-9. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 284, pp. 806-816, ISSN:0022-3565

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (1998). ROLE OF 5-HT4 RECEPTORS IN THE MOUSE PASSIVE AVOIDANCE TEST. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 286, pp. 1115-1121, ISSN:0022-3565 Accesso ONLINE all'editore

C. GHELARDINI; N. GALEOTTI; A. BARTOLINI (1998). Influence of potassium channel modulators on cognitive processes in mice. BRITISH JOURNAL OF PHARMACOLOGY, vol. 123, pp. 1079-1084, ISSN:0007-1188 DOI

C Ghelardini; N Galeotti; S Capaccioli; A Quattrone; A Bartolini (1997). Amnesia induced by ICV treatment with aODN to the K+ channel mKv1.1 gene. JOURNAL OF NEUROCHEMISTRY, vol. 69, pp. S251-S251, ISSN:0022-3042

C. GHELARDINI; N. GALEOTTI; D. BARLOCCO; A. BARTOLINI (1997). ANTINOCICEPTIVE PROFILE OF THE NEW NICOTINIC AGONIST DBO-83. DRUG DEVELOPMENT RESEARCH, vol. 40, pp. 251-258, ISSN:0272-4391

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; M. ROMANELLI; A. BARTOLINI (1997). ANTINOCICEPTION INDUCED BY SM32 DEPENDS ON CENTRAL CHOLINERGIC MECHANISM. PHARMACOLOGICAL RESEARCH, vol. 35, pp. 141-147, ISSN:1043-6618 DOI

C. GHELARDINI; N. GALEOTTI; L. FANTETTI; F. GUALTIERI; S. DEI; S. SCAPECCHI; A. BARTOLINI (1997). Central muscarinic antinociception induced by ET-142 and SS-20 in rodents. DRUG DEVELOPMENT RESEARCH, vol. 42, pp. 26-34, ISSN:0272-4391 DOI

GALEOTTI N.; GHELARDINI C.; S. CAPACCIOLI; QUATTRONE A.; NICOLIN A.; BARTOLINI A. (1997). Blockade of clomipramine and amitriptyline analgesia by an antisense oligonucleotide to mKv1.1, a mouse Shaker-like potassium channe. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 330, pp. 15-25, ISSN:0014-2999 DOI

C. Ghelardini; N. Galeotti; A. Bartolini (1997). Caffeine induces central cholinergic analgesia.. NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 356, pp. 590-595, ISSN:0028-1298 DOI Accesso ONLINE all'editore

C. Ghelardini; N. Galeotti; M. Nicolodi; S. Donaldson; F. Sicuteri; A. Bartolini (1997). Involvement of central cholinergic system in antinociception induced by sumatriptan in mouse.. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH, vol. 17, pp. 105-109, ISSN:0251-1649 Accesso ONLINE all'editore

V. Marchese; C. Ghelardini; N. galeotti; C. Bellucci; D. Manetti; F. Gualtieri; P.A.Borea; A. Bartolini (1997). Antinociceptive and antiamnesic properties of the nicotinic agonist AG-4. In: 27th Annual Meeting Society for neuroscience, New Orleans, LA, 25-30 Ottobre 1997, Society of Neuroscience, pp. 216-216.

N Meiri; C Ghelardini; G Tesco; N Galeotti; D Dahl; D Tomsic; S Cavallaro; A Quattrone; S Capaccioli; A Bartolini; DL Alkon (1997). Antisense to the rodent Shaker-like potassium channel Kv1.1 alters memory without effecting LTP. BIOPHYSICAL JOURNAL, vol. 72, pp. TUAM8-TUAM8, ISSN:0006-3495

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; C. BELLUCCI; D. MANETTI; P. BOREA; A. BARTOLINI (1997). Antinociceptive property of the nicotinic agonist AG4 in rodents. DRUG DEVELOPMENT RESEARCH, vol. 41, pp. 1-9, ISSN:0272-4391 DOI

N. Galeotti ; C. Ghelardini ; L. Papucci ; S. Capaccioli ; A. Quattrone ; A. Bartolini (1997). An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 281, pp. 941-949, ISSN:0022-3565

Silvia Dei; Cristina Bellucci; Fulvio Gualtieri; Dina manetti; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori; Alessandro Bartolini; Carla Ghelardini (1997). Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity. In: First Italian-Swiss Meeting on Medicinal Chemistry, Torino, 23-26 Settembre 1997, Italian Chemical Society e New Swiss Chemical Society Section of Medicinal Chemistry, pp. 57 A3-57 A3.

M Nicolodi; F Sicuteri; C Ghelardini; N Galeotti; A Bartolini (1997). Proposal of an animal model to test specific acute drugs for migraine attacks. CEPHALALGIA, vol. 17, pp. 400-400, ISSN:0333-1024

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; C. BELLUCCI; D. MANETTI; A. GIOTTI; P. MALMBERG; A. GALLI; A. BARTOLINI (1997). Antinociceptive profile of SM21: a novel analgesic with a presynaptic cholinergic mechanism of action. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 282, pp. 430-439, ISSN:0022-3565

S. SCAPECCHI; P. ANGELI; S. DEI; C. GHELARDINI; F. GUALTIERI; G. MARUCCI; F. PAPARELLI; M. ROMANELLI; E. TEODORI (1997). SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER. ARCHIV DER PHARMAZIE, vol. 330, pp. 122-128, ISSN:0365-6233

GHELARDINI C; GALEOTTI N; PECORI VETTORI A; CAPACCIOLI S; QUATTRONE A; A. BARTOLINI (1997). Effect of K+ channel modulation on mouse feeding behaviour. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 329, pp. 1-8, ISSN:0014-2999 DOI

C. GHELARDINI; A. BARTOLINI; N. GALEOTTI; C. BELLUCCI; S. DEI; F. GUALTIERI (1997). In vitro characterization of a novel, potent and selective M3 antagonist. LIFE SCIENCES, vol. 61, pp. 1217-1226, ISSN:0024-3205 DOI

N. MEIRI; C. GHELARDINI; G. TESCO; N. GALEOTTI; D. DAHL; D. TOMSIC; S. CAVALLARO; A. QUATTRONE; S. CAPACCIOLI; A. BARTOLINI; D. ALKON (1997). Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, pp. 4430-4434, ISSN:0027-8424 DOI

C.GHELARDINI; N.GALEOTTI; A.PECORI VETTORI; S.CAPACCIOLI; A.QUATTRONE; A.BARTOLINI (1997). Effects of potassium channels modulation on mouse feeding behaviour.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 329, pp. 1-8, ISSN:0014-2999, Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598:

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; S. SCAPECCHI; A. BARTOLINI (1997). 3-ALFA-TROPANYL 2-(4-Cl-PHENOXY)BUTIRATE (SM21): A REVIEW OF THE PHARMACOLOGICAL PROFILE OF A NOVEL ENHANCER OF CHOLINERGIC TRANSMISSION.. CNS DRUG REVIEWS, vol. 3, pp. 346-362, ISSN:1080-563X DOI

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (1997). 5-HT1A AGONISTS INDUCE CENTRAL CHOLINERGIC ANTINOCICEPTION. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 57, pp. 835-841, ISSN:0091-3057 DOI Accesso ONLINE all'editore

D. MANETTI; P. BOREA; C. GHELARDINI; F. GUALTIERI; M. N. ROMANELLI; S. SCAPECCHI; G. VALLE (1997). REDUCED-FLEXIBILITY HYBRIDS OF THE NICOTINIC AGONISTS 1,1-DIMETHYL-4-ACETYLPIPERAZINIUM IODIDE AND 2-(DIMETHYLAMINO)METHYL-5-CYCLOPENTANONE METHIODIDE. MEDICINAL CHEMISTRY RESEARCH, vol. 7, pp. 301-312, ISSN:1054-2523

N. GALEOTTI; C. GHELARDINI; E. TEODORI; F. GUALTIERI; A. BARTOLINI (1997). ANTIAMNESIC ACTIVITY OF METOCLOPRAMIDE, CISAPRIDE AND SR-17 IN THE MOUSE PASSIVE AVOIDANCE TEST. PHARMACOLOGICAL RESEARCH, vol. 36, pp. 59-67, ISSN:1043-6618

S. DEI; A. BARTOLINI; C. BELLUCCI; C. GHELARDINI; F. GUALTIERI; D. MANETTI; M. N. ROMANELLI; S. SCAPECCHI; E. TEODORI (1997). DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, pp. 595-605, ISSN:0223-5234

C. GHELARDINI; F. GUALTIERI; M. ROMANELLI; P. ANGELI; G. PEPEU; M. GIOVANNINI; F. CASAMENTI; P. MALMBERG; A. GIOTTI; A. BARTOLINI (1997). STEREOSELECTIVE INCREASE IN CHOLINERGIC TRANSMISSION BY R-(+)- HYOSCYAMINE. NEUROPHARMACOLOGY, vol. 36, pp. 281-294, ISSN:0028-3908 DOI

C. LAMBERTI; A. BARTOLINI; C. GHELARDINI; P. MALMBERG (1996). INVESTIGATION INTO THE ROLE OF HISTAMINE RECEPTORS IN RODENT ANTINOCICEPTION. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 53, pp. 567-574, ISSN:0091-3057

N. GALEOTTI; C. GHELARDINI; A. BARTOLINI (1996). PIRACETAM AND ANIRACETAM ANTAGONISM OF CENTRALLY ACTIVE DRUG-INDUCED ANTINOCICEPTION. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 53, pp. 943-950, ISSN:0091-3057 DOI Accesso ONLINE all'editore

C. GHELARDINI; N. GALEOTTI; F. GUALTIERI; S. SCAPECCHI; A. BARTOLINI (1996). R-(+)-HYOSCYAMINE: A PERIPHERAL CHOLINERGIC AMPLIFER. PHYTOTHERAPY RESEARCH, vol. 10, pp. 62-64, ISSN:0951-418X

Maria Novella Romanelli; Cristina Bellucci; Silvia Dei; Fulvio Gualtieri; Dina Manetti; Serena Scapecchi; Elisabetta Teodori; Carla Ghelardini; Alessandro Bartolini; Piero Borea (1996). Progettazione, Sintesi e studio di molecular modeling di nuovi ligandi nicotinici. In: XIII Convegno Nazionale Divisione di Chimica Farmaceutica, Paestum (SA), 23-27 Settembre 1996, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 67 Atti C-M1-67 Atti C-M1.

M. ROMANELLI; A. BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M. GIOVANNINI; F. GUALTIERI; G. PEPEU; S. SCAPECCHI; E. TEODORI; (1996). Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent.. CHIRALITY, vol. 8, pp. 579-584, ISSN:0899-0042 DOI

D. MANETTI; M. ROMANELLI; A. BARTOLINI; S. DEI; C. GHELARDINI; F. GUALTIERI; R. MATUCCI; S. SCAPECCHI; E. TEODORI (1996). REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS. ARCHIV DER PHARMAZIE, vol. 329, pp. 105-111, ISSN:0365-6233

C. GHELARDINI; A. BARTOLINI; N. GALEOTTI; E. TEODORI; F. GUALTIERI (1996). S(-)ET126: a potent and selective M1 antagonist in vitro and in vivo. LIFE SCIENCES, vol. 58, pp. 991-1000, ISSN:0024-3205 DOI

N. Galeotti; F. Follegatti; S. Donaldson; D. Manetti; C. Ghelardini (1996). Valutazione dell'attività antinocicettiva dell'agonista nicotinico AG-4 in topi e ratti. In: Società Italiana di Neuroscienze V Convegno Nazionale, Pisa, 12-14 Dicembre 1996, Società Italiana di Neuroscienze, pp. D10-D10.

G. PEPEU; M.G. VANNUCCHI; M.G. GIOVANNINI; C. GHELARDINI; F. GUALTIERI. (1996). Effects of presynaptic muscarinic antagonists. JOURNAL OF NEUROCHEMISTRY, vol. 66, Suppl. 2, pp. 1015-1015, ISSN:0022-3042

Galeotti N; Ghelardini C; Quattrone A; Schiavone N; Capaccioli S; Bartolini A (1996). Baclofen antinociception is prevented by ICV injection of pertussis toxin and by an aODN to the mKv1.1 potassium channel... In: 3rd International GABA(B) Symposium., BAIA PARAELIOS, ITALY, SEP 21-25, 1996, Elsevier B.V., vol. 8, pp. 135-140.

M.N. ROMANELLI; A.BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M.G. GIOVANNINI; F. GUALTIERI; G. PEPEU; S. SCAPECCHI; E. TEODORI (1996). Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs. CHIRALITY, vol. 8, pp. 225-233, ISSN:0899-0042 DOI

C. Ghelardini; N. Galeotti; F. Casamenti; P. Malmberg-Aiello; G. Pepeu; F. Gualtieri; A. Bartolini (1996). Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8. LIFE SCIENCES, vol. 58, pp. 2297-2309, ISSN:0024-3205 DOI

GALEOTTI N; C. GHELARDINI; BARTOLINI A (1996). Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception.. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 308, pp. 125-133, ISSN:0014-2999 DOI

P. Dolara; C. Luceri; C. Ghelardini; C. Monserrat; S. Aiolli; F. Luceri; M. Lodovici; S. Menichetti; M. Romanelli (1996). Analgesic effects of myrrh. NATURE, vol. 379, pp. 29-29, ISSN:0028-0836

R.Matucci; B.Bianchi; L.Mantelli; C.Ghelardini; G.B.Vannelli; M.Maggi (1996). Influence of oestrogens on muscarinic receptor density and contractile response in the guinea-pig uterus.. JOURNAL OF REPRODUCTION AND FERTILITY, vol. 107, pp. 153-160, ISSN:0022-4251

S. DEI; C. BELLUCCI; C. GHELARDINI; M. ROMANELLI; S. SPAMPINATO (1996). SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS. LIFE SCIENCES, vol. 58, pp. 2147-2153, ISSN:0024-3205

C. GHELARDINI; N. GALEOTTI; M. NICOLODI; F. SICUTERI; A. BARTOLINI; M. FIGINI; A. IMPERATO; G. GESSA (1996). THE CENTRAL CHOLINERGIC SYSTEM HAS A ROLE IN THE ANTINOCICEPTION INDUCED IN RODENTS AND GUINEA-PIGS BY THE ANTIMIGRAINE DRUG SUMATRIPTAN. THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 279, pp. 884-890, ISSN:0022-3565

N Galeotti; C Ghelardini; A Bartolini (1995). Involvement of the serotoninergic system in the analgesic effect of tricyclic antidepressants. BEHAVIOURAL PHARMACOLOGY, vol. 6, pp. 20-20, ISSN:0955-8810

C. Ghelardini;M. Baldini;N. Galeotti;F. Gualtieri;E. Teodori;A Bartolini (1995). Are the contractions of rabbit peripheral lung, guinea-pig gall-bladder and guinea-pig uterus mediated by identical receptor subtype?. LIFE SCIENCES, vol. 56, pp. 1040-1040, ISSN:0024-3205 DOI

Maria Novella Romanelli; Alessandro Bartolini; Carlo Bertucci; Silvia Dei; Carla Ghelardini; Maria Grazia Giovannini; Fulvio Gualtieri; Giancarlo Pepeu; Serena Scapecchi; Elisabetta Teodori (1995). Stereospecific synthesis and pharmacological evaluation of the enantiomers of SM32, a new central ACh releaser. In: 10th Camerino-Noordwijkerhout Symposium Perspectives in Receptor Research, Camerino, 10-14 settembre 1995, Università degli studi di Camerino, pp. 99-99.

Silvia Dei; Cristina Bellucci; Alessandro Bartolini; Carla Ghelardini; Fulvio Gualtieri; Maria Novella Romanelli; Serena Scapecchi; Elisabetta Teodori (1995). Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina. In: Convegno Nazionale su orientamenti e metodologie in chimica farmaceutica, organica e bioorganica, Numana (AN), 2-6 giugno 1995, Società Chimica Italiana, pp. O40-O40.

Nicoletta Galeotti; Carla Ghelardini; Marco Baldini; Lisa Gherardini; Fulvio Gualtieri; Silvia Dei; Alessandro Bartolini (1995). S-(-)-ET126: a potent and selective M1 antagonist. LIFE SCIENCES, pp. 1051-1051, ISSN:0024-3205

F. GUALTIERI; A. BARTOLINI; C. BERTUCCI; S. DEI; C. GHELARDINI; M.G. GIOVANNINI; A. GIOTTI; G. PEPEU; M.N. ROMANELLI; S. SCAPECCHI; E. TEODORI. (1995). Alpha-tropanyl esters that increase central ACh release: enantioselectivity studies support a double mechanism of action.. LIFE SCIENCES, vol. 56, pp. 1015-1015, ISSN:0024-3205

Silvia Dei; Cristina Bellucci; Carla Ghelardini; Maria Novella Romanelli; Serena Scapecchi; Santi Spampinato; Elisabetta Teodori (1995). Pharmacological profile of the enantiomers of tropicamide. In: 10th Camerino-Noordwijkerhout Symposium Perpectives in Receptor Research, Camerino, 10-14 settembre 1995, Università degli studi di Camerino, pp. 100-100.

C Ghelardini; N Galeotti; L Fantetti; A Bartolini (1995). Buspirone and gepirone: two anxiolytic drugs endowed with antinociception mediated by the cholinergic system. BEHAVIOURAL PHARMACOLOGY, vol. 6, pp. 42-43, ISSN:0955-8810

Dei, Silvia; Bellucci, Cristina; Gualtieri, Fulvio; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Ghelardini, Carla (1995). ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE. IL FARMACO, vol. 50, pp. 303-309, ISSN:0014-827X

P. MALMBERG; C. LAMBERTI; C. GHELARDINI; A. GIOTTI; A. BARTOLINI (1994). Role of histamine in rodent antinociception. BRITISH JOURNAL OF PHARMACOLOGY, vol. 111, pp. 1269-1279, ISSN:0007-1188

A BARTOLINI; L FANFANI; N GALEOTTI; C GHELARDINI; A GIOTTI; P MALMBERG-AIELLO; P MEONI (1994). Antagonism by piracetam of baclofen antinociception. BRITISH JOURNAL OF PHARMACOLOGY, vol. 111, pp. P95-P95, ISSN:0007-1188

F. GUALTIERI; C. BOTTALICO; A. CALANDRELLA; S. DEI; M. GIOVANNONI; S. MEALLI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; N. GALEOTTI; C. GHELARDINI; A. GIOTTI; A. BARTOLINI (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1712-1719, ISSN:0022-2623 DOI

Gualtieri, Fulvio; Conti, G.; Dei, Silvia; Giovannoni, MARIA PAOLA; Nannucci, F.; Romanelli, MARIA NOVELLA; Scapecchi, Serena; Teodori, Elisabetta; Fanfani, L.; Ghelardini, Carla; Giotti, Alberto; Bartolini, Alessandro (1994). Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters. JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, pp. 1704-1711, ISSN:0022-2623

M.N. Romanelli; A. Bartolini; S. Dei; C. Ghelardini; F. Gualtieri; D. Manetti; R. Matucci; S. Scapecchi; E. Teodori (1994). Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica. In: XI Convegno Nazionale Divisione di Chimica Farmaceutica Società Chimica Italiana, Bari, 2-5 Ottobre 1994, Società Chimica Italiana Divisione di Chimica Farmaceutica, pp. 96-96.

Galeotti, N; Fanfani, L; Meonin, P; Ghelardini, C; Giotti, A; Gualtieri, F; Romanelli, Mn; Bartolini, A (1993). Effect of 5-HT4 agonists metoclopramide and Compound 1 on learning and memory. In: XXI International Congress of Neurovegetative Research, Elsevier, vol. 43, pp. 78-79.

F. FRANCHINI; F. CHIAIA NOJA; F. CORBO; G. LENTINI; V. TORTORELLA; A. BARTOLINI; C. GHELARDINI; R. MATUCCI; A. GIOTTI (1993). STEREOSELECTIVITY IN CENTRAL ANALGESIC ACTION OF TOCAINIDE AND ITS ANALOGS. CHIRALITY, vol. 5, pp. 135-142, ISSN:0899-0042

Romanelli, MARIA NOVELLA; Ghelardini, Carla; Dei, Silvia; Matucci, Rosanna; Mori, Francesca; Scapecchi, Serena; Teodori, Elisabetta; Bartolini, Alessandro; Galli, Alessandro; Giotti, Alberto; Gualtieri, Fulvio (1993). SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER. ARZNEIMITTEL-FORSCHUNG, vol. 43 (II), pp. 913-918, ISSN:0004-4172

A. BARTOLINI; C. GHELARDINI; L. FANTETTI; M. MALCANGIO; P. MALMBERG; A. GIOTTI (1992). ROLE OF MUSCARINIC RECEPTOR SUBTYPES IN CENTRAL ANTINOCICEPTION. BRITISH JOURNAL OF PHARMACOLOGY, vol. 105, pp. 77-82, ISSN:0007-1188

C. GHELARDINI; A. GIOTTI; F. GUALTIERI; R. MATUCCI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI (1992). PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN. In: 8. TRENDS IN RECEPTOR RESEARCH, pp. 95-114, ELSEVIER SCIENCE PUBLISHERS B. V. AMSTERDAM: P. ANGELI, U. GULINI, W. QUAGLIA.

C. GHELARDINI; L. FANTETTI; M. MALCANGIO; P. MALMBERG; A. GIOTTI; A. BARTOLINI (1992). INVOLVEMENT OF CENTRAL CHOLINERGIC NEUROTRANSMISSION IN METOCLOPRAMIDE ANALGESIA. PHARMACOLOGICAL RESEARCH, vol. 25, pp. 25-26, ISSN:1043-6618

M. MALCANGIO; C. GHELARDINI; A. GIOTTI; P. MALMBERG; A. BARTOLINI (1991). CGP 35348, A NEW GABAB ANTAGONIST, PREVENTS ANTINOCICEPTION AND MUSCLE-RELAXANT EFFECT INDUCED BY BACLOFEN. BRITISH JOURNAL OF PHARMACOLOGY, vol. 103, pp. 1303-1308, ISSN:0007-1188

F. GUALTIERI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI; L. FANTETTI; C. GHELARDINI; A. GIOTTI (1991). MUSCARINIC PRESYNAPTIC AUTORECEPTORS AND MUSCARINIC POSTSYNAPTIC RECEPTORS HAVE OPPOSITE STEREOCHEMICAL REQUIREMENTS. MEDICINAL CHEMISTRY RESEARCH, vol. 1, pp. 52-58, ISSN:1054-2523

M. MALCANGIO; L. PIZZIGHELLI; C. GHELARDINI; P. MALMBERG; A. GIOTTI; A. BARTOLINI (1990). CROSS-TOLERANCE BETWEEN BACLOFEN AND BICUCULLINE ANTINOCICEPTION. PHARMACOLOGICAL RESEARCH, vol. 22, pp. 5-6, ISSN:1043-6618

C. GHELARDINI; P. MALMBERG; A. GIOTTI; M. MALCANGIO; A. BARTOLINI (1990). INVESTIGATION INTO ATROPINE-INDUCED ANTINOCICEPTION. BRITISH JOURNAL OF PHARMACOLOGY, vol. 101, pp. 49-54, ISSN:0007-1188

C. GHELARDINI; A. BARTOLINI; P. MALMBERG; M. MALCANGIO; A. GIOTTI (1989). ENKEPHALINASE INHIBITOR THIORPHAN GREATLY POTENTIATES ANTINOCICEPTION INDUCED BY VERY LOW DOSES OF NALOXONE. PHARMACOLOGICAL RESEARCH, vol. 21, pp. 631-632, ISSN:1043-6618

M. MALCANGIO; A. BARTOLINI; C. GHELARDINI; P. MALMBERG; F. FRANCONI; A. GIOTTI; F. BENNARDINI (1989). EFFECT OF ICV TAURINE ON THE IMPAIRMENT OF LEARNING, CONVULSION AND DEATH CAUSED BY HYPOXIA. PSYCHOPHARMACOLOGY, vol. 98, pp. 316-320, ISSN:0033-3158

A. BARTOLINI; A. GALLI; C. GHELARDINI; A. GIOTTI; M. MALCANGIO; P. MALMBERG; P. ZUCCHI (1987). ANTINOCICEPTION INDUCED BY SYSTEMIC ADMINISTRATION OF LOCAL ANAESTHETICS DEPENDS ON A CENTRAL CHOLINERGIC MECHANISM. BRITISH JOURNAL OF PHARMACOLOGY, vol. 92, pp. 711-721, ISSN:0007-1188

Carla GHELARDINI

Carla GHELARDINI

Carla GHELARDINI

Carla GHELARDINI

Carla GHELARDINI

Carla GHELARDINI

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