Structural, fisical and chemical properties of proteins. Enzymes: mechanism of action and enzyme kinetic. Competitive, non competitive and acompetitive inhibitors. Mechanisms of enzyme regulation. Action mechanism of hormones and receptors. Fat- and water-soluble vitamins. Metabolic pathways and their control. Bioenergetics and oxidative metabolism. Compounds with high energy. Adsorption and metabolism of carbohydrates, lipids, proteins and nucleic acids. Iron and eme metabolism.
Course program
First part: Structure and properties of amino acids. Peptide bond. Physico-chemical properties of proteins. Primary, secondary, tertiary and quaternary structure. Fibrous proteins and globular proteins (collagen, hemoglobin). Main kinetic characteristics of enzymes, classification, enzyme inhibitors. Coenzymes. General characteristics of hormones. Water-soluble and fat-soluble vitamins. Regulation of metabolism. Bioenergetics. High energy compounds.
Part II: Metabolism of carbohydrates (starch, glycogen, glucose). Tricarboxylic acid cycle. Respiratory chain and oxidative phosphorylation. Metabolism of lipids (fatty acids, triglycerides, cholesterol and ketone bodies). Catabolism of proteins and amino acids (deamination and transamination reactions), synthesis of compounds derived from amino acids (adrenaline, thyroid hormones, heme). Ureogenesi. Principal reactions of the biosynthetic and catabolic process of purine and pyrimidine nucleotides. Structural and functional characteristics of nucleic acids