Pre-clinical and Clinical trial of drugs. Pharmacokinetic. Pharmacodynamic: actions of drugs mediated by receptors; actions of drugs on enzymatic systems; actions of drugs on carriers, on ion channels, on transporter and pumps.Tolerance. Physical dependence. Withdrawal syndrome. Tachyphylaxis. Idiosyncratic and Allergic reactions. Drug resistance. Drug-drug interactions and Drug-food interactions
Teaching Methods
Frontal lessons
Type of Assessment
Oral examination
Course program
Pre-clinical and Clinical trial of drugs: Phases of clinical trial.
Pharmacokinetic: transfer of drugs across biological membranes; administration routs of drugs; distribution of drugs in body; metabolism of drugs; excretion of drugs. Pharmaco-dynamic: actions of drugs not mediated by receptors; actions of drugs on enzymatic systems; actions of drugs mediated by receptors; actions of drugs on carriers; actions of drugs on ion channels. Desensitization of receptors. Tolerance. Physical dependence. Withdrawal syndrome. Tachyphylaxis. Idiosyncratic and Allergic reactions. Resistance to antimicrobial and antineoplastic agents. Drug-drug interactions and Drug-food interactions