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B017001 - MOLECULAR BIOLOGY
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2016-17
Course year
First year - Second Semester
Belonging Department
Biomedical, Experimental and Clinical Sciences "Mario Serio"
Modulo di sola Frequenza of
Scientific Area
BIO/11 - MOLECULAR BIOLOGY
Credits
3
Teaching Hours
24
Teaching Term
01/03/2017 ⇒ 30/04/2018
Attendance required
No
Type of Evaluation
Giudizio Finale
Course Content
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Course program
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Lectureship
Teaching Language
italian
Course Content
Transcriptional control in eukaryotes. Muscular differentiation. Post-transcriptional modifications. Patent policies in the biomedical field.
Suggested readings (Search our library's catalogue)
Alberts: Biologia molecolare della cellula. Feltrinelli
Learning Objectives
Deepen the knowledge about transcriptional regulation and about some related processes.
Prerequisites
Good knowledge of basic molecular biology.
Teaching Methods
Lectures
Further information
the course is held in the last part of the semester
Type of Assessment
written exam
Course program
Transcriptional regulation in eukariotes. Determination of the transcription initiation site. Most common elements on DNA and transcriptional factor. MT gene structure. Structural protein motif for DNA interaction. Nuclear receptors for lipophylic hormons. HF1 factor. EMT transition: transcriptional factors.
Chromatin and histonic code. RNA pol. I and III. tRNA maturation. Apoptosis:apoptotic and anti-apoptotic genes, intrinsecal and extrinsecal pathway. Apoptosis experimental evaluation. Apoptosis and tumorigenesis (oncogenes and onco-suppressors involved in apoptosis). p53 and tumors. Muscular differentiation. Splicing, alternative and aberrant splicing. The CRISPR tecnique.
Chromatin and histonic code. RNA pol. I and III. tRNA maturation. Apoptosis:apoptotic and anti-apoptotic genes, intrinsecal and extrinsecal pathway. Apoptosis experimental evaluation. Apoptosis and tumorigenesis (oncogenes and onco-suppressors involved in apoptosis). p53 and tumors. Muscular differentiation. Splicing, alternative and aberrant splicing. The CRISPR tecnique.