ITA | ENG
B016685 - CHEMOTHERAPY
Main information
Teaching Language
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Type of Assessment
Course program
Academic Year 2018-19
Coorte 2015 - 5-years Single Cycle Degree in PHARMACY
Course year
Fourth year - First Semester
Belonging Department
Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA)
Modulo Generico of
Scientific Area
BIO/14 - PHARMACOLOGY
Credits
3
Teaching Hours
24
Teaching Term
24/09/2018 ⇒ 30/04/2020
Attendance required
No
Type of Evaluation
Final Grade
Course program
show
Lectureship
Teaching Language
Italian
Suggested readings (Search our library's catalogue)
F. Rossi, V. Cuomo, C. Riccardi Ed. Farmacologia: Principi di base e applicazioni terapeutiche, III edizione, Ed Minerva Medica, Torino 2017
Slides of lessons
Slides of lessons
Learning Objectives
ANTIMICROBIAL CHEMOTHERAPY:
Students will achieve extensive knowledge on the selective toxicity, etiotropic peculiarity and mechanism of action of the different antimicrobial classes as the rationale for their use either in prophylaxis or in treatment of infectious diseases. Students will learn the basic concepts of microbial resistance and will have to know drug prototypes and the main molecules of the different classes to identify their basilar pharmacodynamic, pharmacokinetic and toxicological properties. Finally, students must be capable to properly place in therapy single molecules or groups of antimicrobial drugs, taking into account the continuous evolution of causative pathogens and hospital or community acquired infectious diseases.
ANTICANCER CHEMOTHERAPY:
The student will acquire knowledge concerning mechanisms of action of different classes of drugs as a rational basis of their use in the treatment of cancer. Also, the student will have to know drug prototypes of different classes, to identify their main pharmacological and clinical properties as well as their appropriate therapeutic collocation
Students will achieve extensive knowledge on the selective toxicity, etiotropic peculiarity and mechanism of action of the different antimicrobial classes as the rationale for their use either in prophylaxis or in treatment of infectious diseases. Students will learn the basic concepts of microbial resistance and will have to know drug prototypes and the main molecules of the different classes to identify their basilar pharmacodynamic, pharmacokinetic and toxicological properties. Finally, students must be capable to properly place in therapy single molecules or groups of antimicrobial drugs, taking into account the continuous evolution of causative pathogens and hospital or community acquired infectious diseases.
ANTICANCER CHEMOTHERAPY:
The student will acquire knowledge concerning mechanisms of action of different classes of drugs as a rational basis of their use in the treatment of cancer. Also, the student will have to know drug prototypes of different classes, to identify their main pharmacological and clinical properties as well as their appropriate therapeutic collocation
Prerequisites
• General pharmacology (pharmacodynamics and pharmacokinetics)
• Concepts of basic microbiology
• Concepts of basic biochemistry
• Concepts of basic microbiology
• Concepts of basic biochemistry
Teaching Methods
Lessons
Type of Assessment
Oral exam. At least two questions on antimicrobial chemotherapy and anticancer chemotherapy topics
Course program
ANTIMICROBIAL CHEMOTHERAPY:
Historical and general aspects of antimicrobial agents
Principles of selective toxicity
General aspects of microbial chemoresistance
General concepts of pharmacokinetic-pharmacodynamic (PK-PD) relationship of antimicrobial drugs.
Betalactams
Glycosidic macrolides
Fluoroquinolones
Aminoglycosides
Glycopeptides
Oxazolidinones
Lypopeptides (Daptomycin)
Tetracyclines and Glycilcyclines
Sulphonamides, Diaminopyrimidines and their combinations
Polymyxins
Antitubercular Drugs
Polyenes
Azoles and triazoles
Echinocandines
Anti-malarics
Antivirals
ANTICANCER CHEMOTHERAPY:
General characteristics of anticancer agents
Side effects of cytotoxic agents and targeted drugs
Mechanisms of tumor drug resistance
Cytotoxic agents
- Alkylating agents (nitrogen mustards, triazenes, platinum coordination complexes)
- Antimetabolites (antifolates and fluoropyrimidines)
- Anticancer agents from natural sources (Vinca alkaloids, taxanes, camptothecins, anthracyclines)
Targeted drugs
- Protein kinase inhibitors (in particular imatinib, vemurafenib)
- Monoclonal antibodies (in particular anti-CD20 (rituximab), anti-EGFR (cetuximab), anti-HER2 (trastuzumab) monoclonal antibodies)
Immunotherapeutic drugs (checkpoint inhibitors)
Historical and general aspects of antimicrobial agents
Principles of selective toxicity
General aspects of microbial chemoresistance
General concepts of pharmacokinetic-pharmacodynamic (PK-PD) relationship of antimicrobial drugs.
Betalactams
Glycosidic macrolides
Fluoroquinolones
Aminoglycosides
Glycopeptides
Oxazolidinones
Lypopeptides (Daptomycin)
Tetracyclines and Glycilcyclines
Sulphonamides, Diaminopyrimidines and their combinations
Polymyxins
Antitubercular Drugs
Polyenes
Azoles and triazoles
Echinocandines
Anti-malarics
Antivirals
ANTICANCER CHEMOTHERAPY:
General characteristics of anticancer agents
Side effects of cytotoxic agents and targeted drugs
Mechanisms of tumor drug resistance
Cytotoxic agents
- Alkylating agents (nitrogen mustards, triazenes, platinum coordination complexes)
- Antimetabolites (antifolates and fluoropyrimidines)
- Anticancer agents from natural sources (Vinca alkaloids, taxanes, camptothecins, anthracyclines)
Targeted drugs
- Protein kinase inhibitors (in particular imatinib, vemurafenib)
- Monoclonal antibodies (in particular anti-CD20 (rituximab), anti-EGFR (cetuximab), anti-HER2 (trastuzumab) monoclonal antibodies)
Immunotherapeutic drugs (checkpoint inhibitors)