B016779 - IMMUNOLOGY

Italian

General elements on immune response; Innate Immunity; Adaptive immunity; T and B lymphocytes’ ontogenesis; Lymphocytes’ trafficking and homing; Antigen presentation; Major histocompatibility complexes; Effector mechanisms of cellular adaptive immune response; Effector mechanisms of humoral adaptive immune response; Functions of the different Ig isotype; Immunologic tolerance and autoimmunity; Immunodeficiencies; Immunopathologies

General elements on immune response.
1. General aspects of the Immune System
2. Cells of the Immune System
3. Lymphoid Tissues
Innate Immunity.
1. Cells of the innate immunity
2. Functional aspects of the cells of the innate immunity
Adaptive immunity.
1. General aspects of the adaptive immunity
2. Cells of the adaptive immunity
3. Antigen receptor of the T and B cells (TCT and BCR)
4. Phases of the adaptive immune responses
Lymphocytes’ ontogenesis.
1. T cells ontogenesis: role of the thymus
2. B cells ontogenesis: role of the bone marrow
3. Lymphocytes’ trafficking and homing: Integrins, selectins and chemokines
Antigen presentation.
1. Antigens and immunogenes
2. Major histocompatibility complexes
3. Antigen capture and processing
4. Antigen presentation and T cell activation
Effector mechanisms of cellular adaptive immune response.
1. Cytokines production by T cells
2. Effector function of CD4 Th cells
3. Effector function of CD8 Tc cells
4. Function of T regulatory cells
Effector mechanisms of humoral adaptive immune response.
1. Phases of the adaptive humoral immune response
2. B lymphocytes activation: T cell dependent activation; T cell independent activation
3. B cell activation by the different Th cells
4. Regulation of humoral immune responses
5. Functions of the different Ig isotype:
- neutralization of pathogens and tossins
- opsonisation of the pathogens
- antibody dependent cell cytotoxicity (ADCC)
- activation of the complement-the classical pathway
Immunologic tolerance and autoimmunity.
1. Central tolerance
2. Peripheral tolerance
3. Genetic factors associated to autoimmunity
4. Role of infection in the outcome of autoimmunity
Immunodeficiencies.
1. Primary immunodeficiencies
2. Secondary immunodeficiencies
3. Acquired immunodeficiency syndrome (AIDS)
Immunopathologies.
1. Classification of Immunopathologic reactions (IPR)
- type I IPR
- type II IPR
- type III IPR
- type IV IPR
- type V IPR
Vaccination: principles and strategies.
Immunosuppressive tools.