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B021422 - OXIDATIVE STRESS: FROM RESEARCH TO CLINICAL PRACTICE
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Further information
Type of Assessment
Course program
Academic Year 2019-20
Course year
Third year - Annualità singola
Belonging Department
Experimantal and Clinical Medicine
Course Type
Single education field course
Scientific Area
-
Credits
3
Teaching Hours
24
Teaching Term
30/09/2019 ⇒ 12/06/2020
Attendance required
No
Type of Evaluation
Giudizio Finale
Course Content
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Course program
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Lectureship
Teaching Language
Italian
Course Content
1. General Part concerning the biochemical bases of ROS and their derivatives useful to better understand biologic and biochemical processes
2. Specific Part concerning the study of the role of ROS and their derivatives in human physiology and pathology and the main markers of oxidative stress and their measure methodologies are described.
2. Specific Part concerning the study of the role of ROS and their derivatives in human physiology and pathology and the main markers of oxidative stress and their measure methodologies are described.
Suggested readings (Search our library's catalogue)
Chiurchiù- Maccarone
"I radicali liberi e la loro rilevanza in Medicina: dai meccanismi molecolari alle prospettive terapeutiche"
Ed. Piccin
"I radicali liberi e la loro rilevanza in Medicina: dai meccanismi molecolari alle prospettive terapeutiche"
Ed. Piccin
Learning Objectives
At the end of the course the student will be able to:
Evaluate the clinical and diagnostic significance of the main redox-related laboratory markers useful in several physiologic and pathologic processes.
Evaluate the clinical and diagnostic significance of the main redox-related laboratory markers useful in several physiologic and pathologic processes.
Prerequisites
Elements of Biochemistry, General Pathology, Clinical Biochemistry.
Teaching Methods
Frontal lessons and laboratory training.
Further information
Please bring a white coat to practice in laboratory.
Type of Assessment
Oral presentation of a scientific paper concerning the course topic.
Course program
Free radicals, Reactive Oxygen species and oxidative stress. Intracellular and extracellular ROS sources. Redox-mediated physiologic and pathologic mechanisms. Antioxidant defenses. Oxidative stress and diet. Oxidative stress and exercise. The role of ROS in human pathology.
Laboratory measure of oxidative stress markers and antioxidant capacity in biological samples: cultured cells, tissues, blood, serum/plasma for diagnostic and therapeutic uses.
ROS and oxidative markers assays by cytofluorimetric, confocal microscopy, spectrophotometric, luminometric approaches.
Laboratory measure of oxidative stress markers and antioxidant capacity in biological samples: cultured cells, tissues, blood, serum/plasma for diagnostic and therapeutic uses.
ROS and oxidative markers assays by cytofluorimetric, confocal microscopy, spectrophotometric, luminometric approaches.