ITA | ENG
B020185 - PHARMACOLOGY
Main information
Teaching Language
Course Content
Suggested readings
Learning Objectives
Prerequisites
Teaching Methods
Type of Assessment
Course program
Academic Year 2020-21
Coorte 2020 - Second Cycle Degree in FOOD SCIENCE
Course year
First year - Second Semester
Belonging Department
Experimantal and Clinical Medicine
Modulo di sola Frequenza of
Scientific Area
BIO/14 - PHARMACOLOGY
Credits
6
Teaching Hours
48
Teaching Term
01/03/2021 ⇒ 11/06/2021
Attendance required
No
Type of Evaluation
Giudizio Finale
Course Content
show
Course program
show
Lectureship
Teaching Language
Italian
Course Content
437/5000
Pharmacokinetics
Pharmacodynamics
Receptors
Food-diet interactions
Sympathetic and parasympathetic systems
NSAIDs
Glucocorticoids and Gout Therapy
Drugs for peptic ulcer, antiemetics, antidiarrheals
Diabetes therapy
Antidyslipidemic drugs
Drugs for blood coagulation disorders
Antihypertensive drugss
Drugs for ischemic heart disease
Alcohol
Use and abuse of drugs in eating disorders
Mycetism and Medicinal Plants
Pharmacokinetics
Pharmacodynamics
Receptors
Food-diet interactions
Sympathetic and parasympathetic systems
NSAIDs
Glucocorticoids and Gout Therapy
Drugs for peptic ulcer, antiemetics, antidiarrheals
Diabetes therapy
Antidyslipidemic drugs
Drugs for blood coagulation disorders
Antihypertensive drugss
Drugs for ischemic heart disease
Alcohol
Use and abuse of drugs in eating disorders
Mycetism and Medicinal Plants
Suggested readings (Search our library's catalogue)
M. Amico-Roxas, A. Caputi, M. Del Tacca. Compendio di Farmacologia Generale e Speciale- Strumenti di Medicina Pratica, UTET, Torino, 2005
Cella SG, Di Giulio AM, Gorio A., Scaglione F. Farmacologia per le lauree sanitarie, Piccin editore
Waller D.G., Renwick A.G., Hillier K. Farmacologia Medica ed Elementi di Terapia con accesso online (2011), Elsevier ISBN: 9788821429200
Cella SG, Di Giulio AM, Gorio A., Scaglione F. Farmacologia per le lauree sanitarie, Piccin editore
Waller D.G., Renwick A.G., Hillier K. Farmacologia Medica ed Elementi di Terapia con accesso online (2011), Elsevier ISBN: 9788821429200
Learning Objectives
776/5000
The course is divided into 2 parts, General Pharmacology and Special Pharmacology.
In the General Pharmacology we will describe the essential characteristics of the pharmacokinetics and pharmacodynamics of the active ingredients used for systemic, topical and diagnostic therapies. Interactions between drugs and between diet and drugs will also be described.
In the Special Pharmacology, various classes of drugs will be dealt with, with particular reference to drugs for some inflammatory diseases, the digestive system, the cardiovascular system and the central nervous system, pain and bacterial infections. For each of these, the reference active ingredients and their use will be identified according to the guidelines of evidence-based medicine.
1st part General Pharmacology
Pharmacokinetics: routes of administration, mechanisms of absorption, factors that influence the passage of drugs through biological membranes. Bioavailability: topical and systemic therapies for diagnostic purposes. Plasma drug-protein binding: plasma half-life time and dose rate.
Distribution of Drugs: Volume of distribution in predicting the duration of drug effect. Redistribution of the drug. Half-life.
Drug metabolism and elimination: Phase I (non-microsomal and microsomal) and phase II reactions. Cytochrome P450 isoforms. Induction and inhibition of drug metabolism. Effect of food components on the activity of cytochrome P450. Influence of genetic polymorphisms. Renal clearance.
Pharmacodynamics: dose-effect relationship: target macromolecules for pharmacologically active ingredients. Definition of agonists (total and partial, allosteric). Competitive and non-competitive antagonists. Receptor specificity and main signal transduction mechanisms. Concept of potency and efficacy, selectivity linked to drug dose. Pro-drug concept. Therapeutic index, pharmacological synergism.
Examples of interactions between drugs, foods and medicinal herbs
Definition of active principle.
Definition of specialty, generic, over-the-counter and diagnostic drugs: principle of bioequivalence; main pharmaceutical and galenic forms;
side effects and adverse events; pharmacoallergy and idiosyncrasy, tolerance and physical and psychological dependence, teratogenicity and mutagenesis;
2nd part Special Pharmacology: the mechanism of action, the indications, the side effects, the main drug and dietary interactions must be known for each class of drugs
Pharmacological treatment of cardiovascular risk factors:
Type 1 and 2 diabetic hyperglycemia, gestational diabetes and hyperuricemia. Treatment of micro and macroangiopathic complications.
Dyslipidemias: ion exchange resins and statins, class differences, reference active ingredients. Framing of the use of statins in the secondary prevention of cardiovascular events in patients at risk, pharmacokinetic classification of the various molecules, side effects.
Hypertension: main active ingredients. Compliance, adherence and tolerance.
Classification of the therapy of ischemic cardiomyopathies: main classes of drugs of the acute phase and of secondary prevention;
Therapy of acute and chronic inflammatory conditions: non-steroidal anti-inflammatory drugs (representative active ingredients) and steroids;
Treatment of the main diseases of the gastrointestinal system: gastroprotectors / antacids, pharmacological eradication of Helicobacter pylori;
Prokinetics, purgatives, laxatives, antidiarrheals: main drug interactions; Main antiemetic drugs
Haemocoagulative disorders: Indications and therapeutic objectives of the main antiplatelet and anticoagulants. Notes on the use of fibrinolytics and antihemorrhagics. Drug and dietary interactions.
Use and abuse of drugs in eating disorders
Addiction to ethanol
Principles of toxicology: acute mycetism, herbicide poisoning
Medicinal herbs and food supplements
The course is divided into 2 parts, General Pharmacology and Special Pharmacology.
In the General Pharmacology we will describe the essential characteristics of the pharmacokinetics and pharmacodynamics of the active ingredients used for systemic, topical and diagnostic therapies. Interactions between drugs and between diet and drugs will also be described.
In the Special Pharmacology, various classes of drugs will be dealt with, with particular reference to drugs for some inflammatory diseases, the digestive system, the cardiovascular system and the central nervous system, pain and bacterial infections. For each of these, the reference active ingredients and their use will be identified according to the guidelines of evidence-based medicine.
1st part General Pharmacology
Pharmacokinetics: routes of administration, mechanisms of absorption, factors that influence the passage of drugs through biological membranes. Bioavailability: topical and systemic therapies for diagnostic purposes. Plasma drug-protein binding: plasma half-life time and dose rate.
Distribution of Drugs: Volume of distribution in predicting the duration of drug effect. Redistribution of the drug. Half-life.
Drug metabolism and elimination: Phase I (non-microsomal and microsomal) and phase II reactions. Cytochrome P450 isoforms. Induction and inhibition of drug metabolism. Effect of food components on the activity of cytochrome P450. Influence of genetic polymorphisms. Renal clearance.
Pharmacodynamics: dose-effect relationship: target macromolecules for pharmacologically active ingredients. Definition of agonists (total and partial, allosteric). Competitive and non-competitive antagonists. Receptor specificity and main signal transduction mechanisms. Concept of potency and efficacy, selectivity linked to drug dose. Pro-drug concept. Therapeutic index, pharmacological synergism.
Examples of interactions between drugs, foods and medicinal herbs
Definition of active principle.
Definition of specialty, generic, over-the-counter and diagnostic drugs: principle of bioequivalence; main pharmaceutical and galenic forms;
side effects and adverse events; pharmacoallergy and idiosyncrasy, tolerance and physical and psychological dependence, teratogenicity and mutagenesis;
2nd part Special Pharmacology: the mechanism of action, the indications, the side effects, the main drug and dietary interactions must be known for each class of drugs
Pharmacological treatment of cardiovascular risk factors:
Type 1 and 2 diabetic hyperglycemia, gestational diabetes and hyperuricemia. Treatment of micro and macroangiopathic complications.
Dyslipidemias: ion exchange resins and statins, class differences, reference active ingredients. Framing of the use of statins in the secondary prevention of cardiovascular events in patients at risk, pharmacokinetic classification of the various molecules, side effects.
Hypertension: main active ingredients. Compliance, adherence and tolerance.
Classification of the therapy of ischemic cardiomyopathies: main classes of drugs of the acute phase and of secondary prevention;
Therapy of acute and chronic inflammatory conditions: non-steroidal anti-inflammatory drugs (representative active ingredients) and steroids;
Treatment of the main diseases of the gastrointestinal system: gastroprotectors / antacids, pharmacological eradication of Helicobacter pylori;
Prokinetics, purgatives, laxatives, antidiarrheals: main drug interactions; Main antiemetic drugs
Haemocoagulative disorders: Indications and therapeutic objectives of the main antiplatelet and anticoagulants. Notes on the use of fibrinolytics and antihemorrhagics. Drug and dietary interactions.
Use and abuse of drugs in eating disorders
Addiction to ethanol
Principles of toxicology: acute mycetism, herbicide poisoning
Medicinal herbs and food supplements
Prerequisites
None
Teaching Methods
Lectures or online teaching
Type of Assessment
Multiple choice written test
Course program
1st part General Pharmacology
Pharmacokinetics: routes of administration, mechanisms of absorption, factors that influence the passage of drugs through biological membranes. Bioavailability: topical and systemic therapies for diagnostic purposes. Plasma drug-protein binding: plasma half-life time and dose rate.
Distribution of Drugs: Volume of distribution in predicting the duration of drug effect. Redistribution of the drug. Half-life.
Drug metabolism and elimination: Phase I (non-microsomal and microsomal) and phase II reactions. Cytochrome P450 isoforms. Induction and inhibition of drug metabolism. Effect of food components on the activity of cytochrome P450. Influence of genetic polymorphisms. Renal clearance.
Pharmacodynamics: dose-effect relationship: target macromolecules for pharmacologically active ingredients. Definition of agonists (total and partial, allosteric). Competitive and non-competitive antagonists. Receptor specificity and main signal transduction mechanisms. Concept of potency and efficacy, selectivity linked to drug dose. Pro-drug concept. Therapeutic index, pharmacological synergism.
Examples of interactions between drugs, foods and medicinal herbs
Definition of active principle.
Definition of specialty, generic, over-the-counter and diagnostic drugs: principle of bioequivalence; main pharmaceutical and galenic forms;
side effects and adverse events; pharmacoallergy and idiosyncrasy, tolerance and physical and psychological dependence, teratogenicity and mutagenesis;
2nd part Special Pharmacology: the mechanism of action, the indications, the side effects, the main drug and dietary interactions must be known for each class of drugs
Pharmacological treatment of cardiovascular risk factors:
Type 1 and 2 diabetic hyperglycemia, gestational diabetes and hyperuricemia. Treatment of micro and macroangiopathic complications.
Dyslipidemias: ion exchange resins and statins, class differences, reference active ingredients. Framing of the use of statins in the secondary prevention of cardiovascular events in patients at risk, pharmacokinetic classification of the various molecules, side effects.
Hypertension: main active ingredients. Compliance, adherence and tolerance.
Classification of the therapy of ischemic cardiomyopathies: main classes of drugs of the acute phase and of secondary prevention;
Therapy of acute and chronic inflammatory conditions: non-steroidal anti-inflammatory drugs (representative active ingredients) and steroids;
Treatment of the main diseases of the gastrointestinal system: gastroprotectors / antacids, pharmacological eradication of Helicobacter pylori;
Prokinetics, purgatives, laxatives, antidiarrheals: main drug interactions; Main antiemetic drugs
Haemocoagulative disorders: Indications and therapeutic objectives of the main antiplatelet and anticoagulants. Notes on the use of fibrinolytics and antihemorrhagics. Drug and dietary interactions.
Use and abuse of drugs in eating disorders
Addiction to ethanol
Principles of toxicology: acute mycetism, herbicide poisoning
Medicinal herbs and food supplements
Pharmacokinetics: routes of administration, mechanisms of absorption, factors that influence the passage of drugs through biological membranes. Bioavailability: topical and systemic therapies for diagnostic purposes. Plasma drug-protein binding: plasma half-life time and dose rate.
Distribution of Drugs: Volume of distribution in predicting the duration of drug effect. Redistribution of the drug. Half-life.
Drug metabolism and elimination: Phase I (non-microsomal and microsomal) and phase II reactions. Cytochrome P450 isoforms. Induction and inhibition of drug metabolism. Effect of food components on the activity of cytochrome P450. Influence of genetic polymorphisms. Renal clearance.
Pharmacodynamics: dose-effect relationship: target macromolecules for pharmacologically active ingredients. Definition of agonists (total and partial, allosteric). Competitive and non-competitive antagonists. Receptor specificity and main signal transduction mechanisms. Concept of potency and efficacy, selectivity linked to drug dose. Pro-drug concept. Therapeutic index, pharmacological synergism.
Examples of interactions between drugs, foods and medicinal herbs
Definition of active principle.
Definition of specialty, generic, over-the-counter and diagnostic drugs: principle of bioequivalence; main pharmaceutical and galenic forms;
side effects and adverse events; pharmacoallergy and idiosyncrasy, tolerance and physical and psychological dependence, teratogenicity and mutagenesis;
2nd part Special Pharmacology: the mechanism of action, the indications, the side effects, the main drug and dietary interactions must be known for each class of drugs
Pharmacological treatment of cardiovascular risk factors:
Type 1 and 2 diabetic hyperglycemia, gestational diabetes and hyperuricemia. Treatment of micro and macroangiopathic complications.
Dyslipidemias: ion exchange resins and statins, class differences, reference active ingredients. Framing of the use of statins in the secondary prevention of cardiovascular events in patients at risk, pharmacokinetic classification of the various molecules, side effects.
Hypertension: main active ingredients. Compliance, adherence and tolerance.
Classification of the therapy of ischemic cardiomyopathies: main classes of drugs of the acute phase and of secondary prevention;
Therapy of acute and chronic inflammatory conditions: non-steroidal anti-inflammatory drugs (representative active ingredients) and steroids;
Treatment of the main diseases of the gastrointestinal system: gastroprotectors / antacids, pharmacological eradication of Helicobacter pylori;
Prokinetics, purgatives, laxatives, antidiarrheals: main drug interactions; Main antiemetic drugs
Haemocoagulative disorders: Indications and therapeutic objectives of the main antiplatelet and anticoagulants. Notes on the use of fibrinolytics and antihemorrhagics. Drug and dietary interactions.
Use and abuse of drugs in eating disorders
Addiction to ethanol
Principles of toxicology: acute mycetism, herbicide poisoning
Medicinal herbs and food supplements