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B016909 - GENERAL PATHOLOGY
Main information
Teaching Language
Teaching Methods
Type of Assessment
Course program
Academic Year 2021-22
Course year
Second year - Second Semester
Belonging Department
Experimantal and Clinical Medicine
Course Type
Single education field course
Scientific Area
MED/04 - EXPERIMENTAL MEDICINE AND PATHOPHYSIOLOGY
Credits
6
Teaching Hours
48
Teaching Term
28/02/2022 ⇒ 18/06/2022
Attendance required
No
Type of Evaluation
Final Grade
Course program
show
Lectureship
Teaching Language
Italian
Teaching Methods
Lectures
Type of Assessment
The final test will consist of an oral examination which consists on average of 2-3 questions about the topics in the course program and in the material available in the Moodle platform. The final grade is made by evaluating the clarity of explanation, the ability to link and communication skills of the student.
Course program
GENERAL PATHOLOGY
- Health and disease. Classification of causes of disease. Etiology, pathogen and pathogenesis. Homeostasis. Denomination of biomedical disciplines dealing with etio-pathogenesis, diagnosis, clinics and therapy.
CELL INJURY AND DEATH
- Elementary pathological processes. Cell injury, death (apoptosis, necrosis) and adaptation.
INFLAMMATION AND TISSUE REPAIR
- Inflammation: general concepts. Toxicity and persistence within tissue of pathogen and their relationship to the type of inflammatory response. General characters of acute inflammation.
- Pathophysiology of microcirculation.
- Microvascular changes in acute inflammation. Inflammatory oedema.
- Mediators of acute inflammation. Cytokines.
- Cells of acute inflammation; recruitment and action.
- Abscess and “chronic” abscess.
- Chronicized/chronic diffuse (secondary or primary, “aspecific”) inflammation and chronic granulomatous (primary, “specific”) inflammation.
- Mononuclear phagocyte system. Properties and functions of macrophages. Macrophage activation.
- Granulomas.
- Tissue repair; healing.
- Systemic effects of inflammation.
- Pathophysiology of thermoregulation.
- Hyperthermia and fever.
TISSUE REGENERATION
- Regeneration and repair. General concepts of clonogenic, stem, progenitor, precursor, differentiated and mature cell.
HEMODYNAMIC CHANGES, THROMBOSIS AND SHOCK
- Hemostasis: platelet aggregation, plasma clotting and fibrinolisis.
-Thrombosis, embolia, hypoxias, ischemia, shock, atherosclerosis.
NEOPLASIAS
- General aspects of tumor growth. Etiology and epidemiology of neoplasias. Benign and malignant neoplasias. General denomination of neoplasias.
Natural history of neoplasias: initiation, promotion and progression. Carcinomas in situ, local invasiveness and metastasis.
Molecular bases of neoplasias.
- Health and disease. Classification of causes of disease. Etiology, pathogen and pathogenesis. Homeostasis. Denomination of biomedical disciplines dealing with etio-pathogenesis, diagnosis, clinics and therapy.
CELL INJURY AND DEATH
- Elementary pathological processes. Cell injury, death (apoptosis, necrosis) and adaptation.
INFLAMMATION AND TISSUE REPAIR
- Inflammation: general concepts. Toxicity and persistence within tissue of pathogen and their relationship to the type of inflammatory response. General characters of acute inflammation.
- Pathophysiology of microcirculation.
- Microvascular changes in acute inflammation. Inflammatory oedema.
- Mediators of acute inflammation. Cytokines.
- Cells of acute inflammation; recruitment and action.
- Abscess and “chronic” abscess.
- Chronicized/chronic diffuse (secondary or primary, “aspecific”) inflammation and chronic granulomatous (primary, “specific”) inflammation.
- Mononuclear phagocyte system. Properties and functions of macrophages. Macrophage activation.
- Granulomas.
- Tissue repair; healing.
- Systemic effects of inflammation.
- Pathophysiology of thermoregulation.
- Hyperthermia and fever.
TISSUE REGENERATION
- Regeneration and repair. General concepts of clonogenic, stem, progenitor, precursor, differentiated and mature cell.
HEMODYNAMIC CHANGES, THROMBOSIS AND SHOCK
- Hemostasis: platelet aggregation, plasma clotting and fibrinolisis.
-Thrombosis, embolia, hypoxias, ischemia, shock, atherosclerosis.
NEOPLASIAS
- General aspects of tumor growth. Etiology and epidemiology of neoplasias. Benign and malignant neoplasias. General denomination of neoplasias.
Natural history of neoplasias: initiation, promotion and progression. Carcinomas in situ, local invasiveness and metastasis.
Molecular bases of neoplasias.