MEACCI
Biological macromolecules involved in the development of a tumor and methods for their study. Classification of factors leading to tumor development (radiation, chemical environmental factors, etc.) Regulatory mechanisms in response to radiation damage. Use of radiation in therapy.
Methods of analysis and techniques to evaluate DNA damage, uncontrolled cell growth, metastatic capacity. Molecular techniques of genome analysis (H2Agamma ect ..)
T.A. Brown "Genomi" Ed. Edises
Watson,Biologia Molecolare del Gene . Ed. Zanichelli
Learning Objectives
Knowledge of: terminology used in molecular and cellular biology. Molecular basis of the processes involved in cell growth, death, adhesion and motility and factors involved in regulation; bases of cellular and molecular biology related to the control of cell signaling involved in fundamental biological processes. Tossicologic cellular effects. Tumor cachexia: basics and study approaches. Emerging therapies in breast cancer. Anti-angiogenic therapy. introduction to applied microscopy. Analysis of cell metabolism.
Prerequisites
Basis molecular biology and biochemistry
Teaching Methods
CFU 1.5 12hours
Type of Assessment
written exams (35 minutes) consisting of 2 open questions and 4 multiple choice questions.
Course program
Biological macromolecules involved in the development of a tumor and methods for their study. Classification of factors leading to tumor development (radiation, chemical environmental factors, etc.) Regulatory mechanisms in response to radiation damage. Use of radiation in therapy.
Methods of analysis and techniques to evaluate DNA damage, uncontrolled cell growth, metastatic capacity. Molecular techniques of genome analysis (H2Agamma ect ..).
Tumor cachexia: basics and study approaches. Emerging therapies in breast cancer. Anti-angiogenic therapy. introduction to applied microscopy. Analysis of cell metabolism.