To know how to define the meaning of etiology, pathogenesis, disease, damage and cell death, elementary injury, hypoxia and ischemia, acute and chronic inflammation, to identify the intrinsic and extrinsic agents of disease, cell injury induced by radiation, temperature and trauma and the healing process of wounds, as well as to recognize the molecular basis of cancer, their classification and cancerogenic agents.
At the end of the lessons the student should be able to apply methods and functional procedures for an evaluation process of risks in the specific field of occupational health and safety in the workplace.
Prerequisites
To take the exam is required to pass the exam of FIRST AID AND PHARMACOLOGY
Teaching Methods
Lectures
Further information
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Type of Assessment
Ongoing written test with program and/or evaluation credit.
Written or oral final exam.
Course program
General section
Definition of disease
Etiology - Pathogenesis
Intrinsic and extrinsic pathogen factors, genotype-environment interactions
The environment as cause of disease, susceptibility to disease, multifactorial diseases, examples of genetic diseases triggered by environmental stimuli
Cellular damage: the cell as an elementary patient, cellular targets of damage.
Examples of cellular response to injury: adaptation, biochemical and morphological changes, cell death through necrosis and apoptosis
Summaries on free-radical damage
Tissue damage from hypoxia and ischemia
Acute and chronic inflammation
Environmental and nutritional disease
Physical agents of disease: radiation, immediate and delayed effects, DNA damage
Injuries related to temperature and trauma
Wound healing and modulating factors
Abnormalities of growth and cell differentiation
Atrophy, hypertrophy, aplasia, hyperplasia
Metaplasia and dysplasia
Neoplasia: characteristics of neoplastic growth, concept of benignity and malignancy, histogenetic classification of tumors, initiation and promotion, tumor progression, metastasis, molecular basis of cancer, physical, chemical and viral carcinogenesis.