Quality system in Pharmaceutical production. Drug Design and Discovery. Principles of drug registration process. Pharmaceutical patent. Prodrug approach: aims and development. Peptides and peptidomimetics in medicinal chemistry. Biotechnological drugs. New monoclonal antibodies drugs. Radiopharmaceuticals. Vaccines. Veterinary drugs. Focus on new topics in medicinal chemistry
Learning Objectives
The course aims at deepening the basic concepts of Pharmaceutical Chemistry, illustrating the latest acquisitions in this field, understanding today's strategies, evaluating evolutionary aspects, and deepening useful topics for professional activity
Prerequisites
The course is aimed at students who have gained the knowledge of General Pharmaceutical Chemistry and General Pharmacology and who possess knowledge of General Physiology and Organic Chemistry
Teaching Methods
Theoretical teaching with frontal lessons is mandatory; the material made up of slides and texts is available to students on e-learning platform (Moodle). A written check will be provided for the final evaluation. The first lesson describes the program in detail, how to test the learning.
Type of Assessment
Written tests could be provided. The final evaluation will take into account the clarity of the text and the ability to link the various topics, the ability to explicitly expose the most important aspects of the topics discussed. Examination dates are posted on the CdS website and are prepared for online registration.
Course program
General Information on the Pharmaceutical Industry National / International Industrial Manufacturing Standards. Regulatory affairs interacting with the development of new drugs. Marketing Authorization (AIC). Pharmaceutical Industry: its organization, aspects of the Quality System, Pharmaceutical patents. Discovery and development of a drug. Fundamentals of Drug Design and Molecular Modeling. Propagation: Objectives, requirements and strategies to improve the properties of the parent drug. ADEPT Therapy and EDPS. Classification of Protein and Peptide Drugs. Biological and biotechnological drugs. Monoclonal antibodies: general characteristics and application in the treatment of rheumatoid arthritis and tumors. Conjugated drug-antibody. Peptidomimetics and analogues of peptides: strategies for their development. Chemical and physical instability of the peptides. Human insulin and modified insulins. GLP-1 mimetics and DPP-IV inhibitors. Development of renal peptidomimetic inhibitors: kiren. Endothelin receptor antagonists. Antitumor: tyrosine kinase inhibitors Bcr-abl EGFR, VEGFR and HER2, direct agents on tubulin / microtubules (Vinca alkaloids, taxanes) and topoisomerase I and II inhibitors (camptothecin). Vaccines and vaccine subunits . Veterinary drugs, classification and regulations of the veterinary prescription. Radiopharmaceuticals: principles of radiochemistry, radiopharmaceuticals for imaging and therapy